PE20141149A1 - Anticuerpos monoclonales frente al inhibidor de la ruta del factor tisular (tfpi) - Google Patents

Anticuerpos monoclonales frente al inhibidor de la ruta del factor tisular (tfpi)

Info

Publication number
PE20141149A1
PE20141149A1 PE2013002137A PE2013002137A PE20141149A1 PE 20141149 A1 PE20141149 A1 PE 20141149A1 PE 2013002137 A PE2013002137 A PE 2013002137A PE 2013002137 A PE2013002137 A PE 2013002137A PE 20141149 A1 PE20141149 A1 PE 20141149A1
Authority
PE
Peru
Prior art keywords
tissue factor
tfpi
monoclonal antibodies
antibodies against
path inhibitor
Prior art date
Application number
PE2013002137A
Other languages
English (en)
Spanish (es)
Inventor
Zhuozhi Wang
John Murphy
Tobias Marquardt
Dieter Moosmayer
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46932389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141149(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of PE20141149A1 publication Critical patent/PE20141149A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PE2013002137A 2011-04-01 2012-03-30 Anticuerpos monoclonales frente al inhibidor de la ruta del factor tisular (tfpi) PE20141149A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161471101P 2011-04-01 2011-04-01

Publications (1)

Publication Number Publication Date
PE20141149A1 true PE20141149A1 (es) 2014-08-28

Family

ID=46932389

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013002137A PE20141149A1 (es) 2011-04-01 2012-03-30 Anticuerpos monoclonales frente al inhibidor de la ruta del factor tisular (tfpi)

Country Status (37)

Country Link
US (5) US20140294832A1 (show.php)
EP (1) EP2694544B1 (show.php)
JP (4) JP6170903B2 (show.php)
KR (2) KR101995302B1 (show.php)
CN (2) CN107090046A (show.php)
AU (3) AU2012236296A1 (show.php)
BR (1) BR112013025376A2 (show.php)
CA (2) CA2831907C (show.php)
CL (1) CL2013002811A1 (show.php)
CO (1) CO6890074A2 (show.php)
CR (1) CR20130499A (show.php)
CU (1) CU20130128A7 (show.php)
CY (1) CY1121538T1 (show.php)
DK (1) DK2694544T3 (show.php)
DO (1) DOP2013000218A (show.php)
EA (2) EA034214B1 (show.php)
EC (1) ECSP13012913A (show.php)
ES (1) ES2722824T3 (show.php)
GT (1) GT201300229A (show.php)
HK (1) HK1243426A1 (show.php)
HR (1) HRP20190467T1 (show.php)
HU (1) HUE042706T2 (show.php)
IL (4) IL228633B (show.php)
LT (1) LT2694544T (show.php)
MX (1) MX2013011218A (show.php)
MY (2) MY165499A (show.php)
PE (1) PE20141149A1 (show.php)
PH (4) PH12013502039B1 (show.php)
PL (1) PL2694544T3 (show.php)
PT (1) PT2694544T (show.php)
RS (1) RS58633B1 (show.php)
SG (2) SG193594A1 (show.php)
SI (1) SI2694544T1 (show.php)
TR (1) TR201905101T4 (show.php)
UA (1) UA113623C2 (show.php)
WO (1) WO2012135671A2 (show.php)
ZA (1) ZA201308169B (show.php)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8466108B2 (en) 2008-12-19 2013-06-18 Baxter International Inc. TFPI inhibitors and methods of use
JP5714505B2 (ja) † 2008-12-22 2015-05-07 ノヴォ ノルディスク アー／エス 組織因子経路阻害因子に対する抗体
CN110835373A (zh) 2010-03-01 2020-02-25 拜耳医药保健有限公司 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
AU2011227714B2 (en) 2010-03-19 2014-09-04 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
EA034214B1 (ru) * 2011-04-01 2020-01-17 Байер Хелфкеа Ллк Выделенное моноклональное антитело или его антигенсвязывающий фрагмент, который связывается с эпитопом ингибитора пути тканевого фактора человека, содержащая его фармацевтическая композиция, способ применения этой композиции и кодирующая антитело молекула нуклеиновой кислоты
CN104302306B (zh) * 2012-03-21 2019-03-22 百深有限责任公司 Tfpi抑制剂及其使用方法
KR20150030639A (ko) 2012-03-30 2015-03-20 바이엘 헬스케어 엘엘씨 프로테아제로 조절된 항체
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
CN105209497B (zh) * 2013-03-15 2021-09-07 诺和诺德股份有限公司 能够特异性结合组织因子途径抑制物上的两个表位的抗体
HRP20180078T1 (hr) 2013-03-15 2018-03-09 Bayer Healthcare Llc VARIJANTE ANTI-TFPI PROTUTIJELA S DIFERENCIJALNIM VEZANJEM U ŠIROKOM RASPONU pH RADI POBOLJŠANE FARMAKOKINETIKE
US10457743B2 (en) 2013-07-19 2019-10-29 Novo Nordisk A/S Antibodies recognizing the N-terminal part of tissue factor pathway inhibitor capable of eliciting pro-coagulant activity
JP6783754B2 (ja) * 2014-09-17 2020-11-11 ノヴォ ノルディスク アー／エス 組織因子経路インヒビター（１〜１６１）上の２つのエピトープに結合する能力がある抗体
EP4279128A3 (en) * 2015-02-25 2024-02-28 Mogam Institute for Biomedical Research Novel antibody binding to tfpi and composition comprising the same
KR102068915B1 (ko) * 2015-08-19 2020-01-22 화이자 인코포레이티드 조직 인자 경로 억제제 항체 및 그의 용도
CN112424593A (zh) * 2018-07-25 2021-02-26 索尼公司 凝血系统分析装置
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06153985A (ja) * 1992-11-16 1994-06-03 Teijin Ltd モノクローナル抗体
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
JP5714505B2 (ja) * 2008-12-22 2015-05-07 ノヴォ ノルディスク アー／エス 組織因子経路阻害因子に対する抗体
CN110835373A (zh) * 2010-03-01 2020-02-25 拜耳医药保健有限公司 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
EA034214B1 (ru) * 2011-04-01 2020-01-17 Байер Хелфкеа Ллк Выделенное моноклональное антитело или его антигенсвязывающий фрагмент, который связывается с эпитопом ингибитора пути тканевого фактора человека, содержащая его фармацевтическая композиция, способ применения этой композиции и кодирующая антитело молекула нуклеиновой кислоты
US8613919B1 (en) * 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations

Also Published As

Publication number Publication date
PT2694544T (pt) 2019-04-02
BR112013025376A2 (pt) 2017-07-25
IL228633B (en) 2018-03-29
CY1121538T1 (el) 2020-05-29
CN103797030A (zh) 2014-05-14
EA201301107A1 (ru) 2014-11-28
UA113623C2 (uk) 2017-02-27
RS58633B1 (sr) 2019-05-31
PH12019500441A1 (en) 2020-10-12
EP2694544B1 (en) 2019-01-23
PH12013502039A1 (en) 2013-12-16
CU20130128A7 (es) 2014-03-26
MY190951A (en) 2022-05-24
PH12019500440A1 (en) 2020-10-12
CO6890074A2 (es) 2014-03-10
ECSP13012913A (es) 2014-02-28
CA2831907A1 (en) 2012-10-04
JP2014511685A (ja) 2014-05-19
AU2017203105A1 (en) 2017-06-01
HRP20190467T1 (hr) 2019-05-03
JP2017113019A (ja) 2017-06-29
EP2694544A2 (en) 2014-02-12
WO2012135671A2 (en) 2012-10-04
DK2694544T3 (en) 2019-04-15
JP2021019619A (ja) 2021-02-18
ZA201308169B (en) 2016-03-30
CN103797030B (zh) 2017-05-31
HUE042706T2 (hu) 2019-07-29
HK1243426A1 (zh) 2018-07-13
CA3068997A1 (en) 2012-10-04
US20190194353A1 (en) 2019-06-27
MX2013011218A (es) 2013-10-17
DOP2013000218A (es) 2013-11-15
EA201991704A2 (ru) 2020-03-31
PH12019500439A1 (en) 2020-10-12
EA034214B1 (ru) 2020-01-17
US20180194857A1 (en) 2018-07-12
KR20190079698A (ko) 2019-07-05
US20140294832A1 (en) 2014-10-02
EA201991704A3 (ru) 2020-06-30
CA2831907C (en) 2020-03-24
IL274686A (en) 2020-06-30
PH12013502039B1 (en) 2013-12-16
US20170107298A1 (en) 2017-04-20
EP2694544A4 (en) 2015-03-25
AU2012236296A1 (en) 2013-10-24
TR201905101T4 (tr) 2019-05-21
GT201300229A (es) 2014-11-13
WO2012135671A3 (en) 2012-12-13
SG10201602606UA (en) 2016-04-28
CN107090046A (zh) 2017-08-25
IL283829A (en) 2021-07-29
NZ615969A (en) 2016-01-29
PL2694544T3 (pl) 2019-07-31
CL2013002811A1 (es) 2014-02-28
IL257145A (en) 2018-03-29
JP6363747B2 (ja) 2018-07-25
AU2019201814A1 (en) 2019-04-04
KR101995302B1 (ko) 2019-07-02
IL228633A0 (en) 2013-12-31
SG193594A1 (en) 2013-10-30
KR20140019428A (ko) 2014-02-14
MY165499A (en) 2018-03-27
IL274686B (en) 2021-09-30
SI2694544T1 (sl) 2019-06-28
JP2018172411A (ja) 2018-11-08
JP6170903B2 (ja) 2017-07-26
ES2722824T3 (es) 2019-08-19
CR20130499A (es) 2013-10-24
US20220041752A1 (en) 2022-02-10
LT2694544T (lt) 2019-04-25

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