PE20120768A1 - Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4\oxadiazol-3-il]-benzoico - Google Patents

Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4\oxadiazol-3-il]-benzoico

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Publication number
PE20120768A1
PE20120768A1 PE2011001746A PE2011001746A PE20120768A1 PE 20120768 A1 PE20120768 A1 PE 20120768A1 PE 2011001746 A PE2011001746 A PE 2011001746A PE 2011001746 A PE2011001746 A PE 2011001746A PE 20120768 A1 PE20120768 A1 PE 20120768A1
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PE
Peru
Prior art keywords
solvent
oxadiazol
benzoic acid
crystalline form
thermogram
Prior art date
Application number
PE2011001746A
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English (en)
Inventor
Young-Choon Moon
Peter Seongwoo Hwang
Neil G Almstead
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Ptc Therapeutics Inc
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Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of PE20120768A1 publication Critical patent/PE20120768A1/es

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/00Drugs for disorders of the urinary system
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  • Health & Medical Sciences (AREA)
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Abstract

REFERIDA A UN PROCESO DE PREPARACION DE UNA FORMA CRISTALINA DEL ACIDO 3-[5-(2-FLUOROFENIL)-[1,2,4]OXADIAZOL-3-IL]-BENZOICO QUE COMPRENDE: A) CRISTALIZAR LA FORMA A MEDIANTE EVAPORACION LENTA DE UN SOLVENTE O UN SISTEMA DE SOLVENTES; B) CRISTALIZAR LA FORMA B MEDIANTE EVAPORACION LENTA DE UN SOLVENTE O SISTEMA DE SOLVENTES; C) EXPONER UNA FORMA CRISTALINA B A UNA HUMEDAD RELATIVA SUPERIOR O IGUAL A 72%; D) MOLER LA FORMA CRISTALINA B A UNA TEMPERATURA AMBIENTE O POR DEBAJO DE LA TEMPERATURA AMBIENTE; E) SUSPENDER LA FORMA CRISTALINA EN UN SOLVENTE O SISTEMA DE SOLVENTES O; F) SUBLIMAR Y CALENTAR LA FORMA CRISTALINA B. DICHA FORMA CRISTALINA SE CARACTERIZA POR UN TERMOGRAMA DE ANALISIS TERMOGRAVIMETRICO QUE TIENE UNA PERDIDA DE MASA DE 0.4364% DE LA MASA TOTAL DE LA MUESTRA AL CALENTARLA ENTRE 32.9C A 204.6C Y UN TERMOGRAMA DE CALORIMETRIA DIFERENCIAL DE BARRIDO QUE TIENEN UN EVENTO ENDOTERMICO CON UNA TEMPERATURA PICO A 244.24C. EL SISTEMA DE SOLVENTES REFERIDO ES SELECCIONADO DE ACETONITRILO, T-BUTANOL, ISOPROPIL ALCOHOL, ISOPROPIL ETER, AGUA Y MEZCLA DE LOS MISMOS
PE2011001746A 2006-09-25 2007-09-25 Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4\oxadiazol-3-il]-benzoico PE20120768A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84732606P 2006-09-25 2006-09-25

Publications (1)

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PE20120768A1 true PE20120768A1 (es) 2012-06-27

Family

ID=39123850

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2007001290A PE20081225A1 (es) 2006-09-25 2007-09-25 Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico
PE2015001242A PE20151445A1 (es) 2006-09-25 2007-09-25 Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico
PE2011001746A PE20120768A1 (es) 2006-09-25 2007-09-25 Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4\oxadiazol-3-il]-benzoico

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Application Number Title Priority Date Filing Date
PE2007001290A PE20081225A1 (es) 2006-09-25 2007-09-25 Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico
PE2015001242A PE20151445A1 (es) 2006-09-25 2007-09-25 Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico

Country Status (29)

Country Link
US (10) US7863456B2 (es)
EP (2) EP2076501B8 (es)
JP (6) JP5714228B2 (es)
KR (1) KR101430144B1 (es)
CN (3) CN104341371A (es)
AR (2) AR062963A1 (es)
AU (1) AU2007300542B2 (es)
BR (1) BRPI0717107A2 (es)
CA (1) CA2663574C (es)
CL (1) CL2007002743A1 (es)
DK (1) DK2076501T3 (es)
ES (2) ES2563958T3 (es)
HK (1) HK1207070A1 (es)
HU (1) HUE028503T2 (es)
IL (1) IL197717A (es)
LT (1) LTC2076501I2 (es)
MX (2) MX344418B (es)
MY (1) MY191209A (es)
NO (1) NO341858B1 (es)
NZ (1) NZ575795A (es)
PE (3) PE20081225A1 (es)
PL (2) PL2076501T3 (es)
PT (1) PT2076501E (es)
SG (2) SG10201609581TA (es)
SI (1) SI2076501T1 (es)
TW (2) TWI452038B (es)
UA (1) UA99600C2 (es)
WO (1) WO2008039431A2 (es)
ZA (1) ZA200901949B (es)

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US20220023268A1 (en) 2022-01-27
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US20160193189A1 (en) 2016-07-07
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