PE20090820A1 - Derivados de piperidina/piperazina - Google Patents

Derivados de piperidina/piperazina

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Publication number
PE20090820A1
PE20090820A1 PE2008000974A PE2008000974A PE20090820A1 PE 20090820 A1 PE20090820 A1 PE 20090820A1 PE 2008000974 A PE2008000974 A PE 2008000974A PE 2008000974 A PE2008000974 A PE 2008000974A PE 20090820 A1 PE20090820 A1 PE 20090820A1
Authority
PE
Peru
Prior art keywords
nrx
piperidine
piperazine derivatives
cycloalkyl
phenyl
Prior art date
Application number
PE2008000974A
Other languages
English (en)
Inventor
Jean-Pierre Andre Marc Bongartz
Joannes Theodorus Maria Linders
Lieven Meerpoel
Lommen Guy Rosalia Eugeen Van
Erwin Coesemans
Mirielle Braeken
Christophe Francis Robert Nestor Buyck
Monique Jenny Marie Berwaer
Waepenaert Katharina Antonia Germania J M De
Peter Walter Maria Roevens
Petr Vladimirivich Davidenko
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38616252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090820(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20090820A1 publication Critical patent/PE20090820A1/es

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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Abstract

REFERIDO A DERIVADOS DE PIPERIDINA/PIPERAZINA DE FORMULA (I): DONDE A ES CH, N; --- ES UN ENLACE OPCIONAL EN EL CASO QUE A SEA C; X ES -O-C(=O)-, -C(=O)-C(=O)-, -NRx-C(=O)-, ENTRE OTROS; Rx ES H, ALQUILO C1-C4; Y ES -C(=O)-NRx-, -NRx-C(=O)-; R1 ES ADAMANTANILO, CICLOALQUILO C3-C6, FENILO, NAFTALENO, ENTRE OTROS; R2 ES CICLOALQUILO C3-C6, FENILO, NAFTALENILO, ENTRE OTROS; R7 ES H, HALO, ALQUILO C1-C4, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO DE PREPARACION. DICHO COMPUESTO TIENE ACTIVIDAD INHIBITORIA DE DGAT Y ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR DGAT1 COMO OBESIDAD, SINDROME DE RESISITENCIA A LA INSULINA
PE2008000974A 2007-06-08 2008-06-06 Derivados de piperidina/piperazina PE20090820A1 (es)

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US8946228B2 (en) 2015-02-03
US20150087629A1 (en) 2015-03-26
RU2478628C2 (ru) 2013-04-10
EP2155198B1 (en) 2014-08-13
ES2522617T3 (es) 2014-11-17
WO2008148849A8 (en) 2009-07-09
WO2008148849A2 (en) 2008-12-11
PA8783401A1 (es) 2009-01-23
TW200916449A (en) 2009-04-16
CL2008001668A1 (es) 2009-07-17
AU2008258558B2 (en) 2013-11-07
RU2009148796A (ru) 2011-07-20
US20160081997A1 (en) 2016-03-24
US20100210618A1 (en) 2010-08-19
WO2008148849A3 (en) 2009-04-16
UY31134A1 (es) 2009-03-02
EP2155198A2 (en) 2010-02-24
JO2972B1 (en) 2016-03-15
TWI438197B (zh) 2014-05-21
CN101678013B (zh) 2014-05-07
MX2009013334A (es) 2010-01-20
AR066153A1 (es) 2009-07-29
AU2008258558A1 (en) 2008-12-11
CA2687243A1 (en) 2008-12-11
JP5443343B2 (ja) 2014-03-19
BRPI0812923A2 (pt) 2014-12-09
US9227935B2 (en) 2016-01-05
CA2687243C (en) 2016-07-12

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