PE20081662A1 - DERIVADOS DE 6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-ILO - Google Patents

DERIVADOS DE 6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-ILO

Info

Publication number
PE20081662A1
PE20081662A1 PE2008000215A PE2008000215A PE20081662A1 PE 20081662 A1 PE20081662 A1 PE 20081662A1 PE 2008000215 A PE2008000215 A PE 2008000215A PE 2008000215 A PE2008000215 A PE 2008000215A PE 20081662 A1 PE20081662 A1 PE 20081662A1
Authority
PE
Peru
Prior art keywords
azepin
dibenzo
oxo
dihydro
propyl
Prior art date
Application number
PE2008000215A
Other languages
English (en)
Inventor
Alexander Flohr
Roland Jacob-Roetne
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39332521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081662(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20081662A1 publication Critical patent/PE20081662A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-ILO DE FORMULA (I) DONDE R1 ES H O ALQUILO INFERIOR(C1-C7) SUSTITUIDO POR HALOGENO; R2 ES ALQUILO INFERIOR(C1-C7); R3 ES ALQUILO INFERIOR(C1-C7) SUSTITUIDO CON HALOGENO, -(CH2)n-CICLOALQUILO(C3-C6) O -(CH2)n-FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, EN DONDE n ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: (R)-2-HIDROXI-2-METIL-N-((S)-6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-IL)-N'-(2,2,3,3,3-PENTAFLUOR-PROPIL)-MALONAMIDA, (S)-2-HIDROXI-2-METIL-N-((S)-6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-IL)-N'-(3,3,3-TRIFLUOR-PROPIL)-MALONAMIDA, (R/S)-2-HIDROXI-N-((S)-6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-IL)-N-(2,2,3,3,3-PENTAFLUOR-PROPIL)-2-PROPIL-MALONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA SECRETASA ? SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, CANCER
PE2008000215A 2007-02-02 2008-01-30 DERIVADOS DE 6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-ILO PE20081662A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07101658 2007-02-02

Publications (1)

Publication Number Publication Date
PE20081662A1 true PE20081662A1 (es) 2008-11-22

Family

ID=39332521

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000215A PE20081662A1 (es) 2007-02-02 2008-01-30 DERIVADOS DE 6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-ILO

Country Status (15)

Country Link
US (1) US7544679B2 (es)
EP (1) EP2109604A1 (es)
JP (1) JP2010517954A (es)
KR (1) KR101150574B1 (es)
CN (1) CN101622232A (es)
AR (1) AR065129A1 (es)
AU (1) AU2008209861B2 (es)
BR (1) BRPI0807341A2 (es)
CA (1) CA2676160A1 (es)
CL (1) CL2008000254A1 (es)
IL (1) IL199973A0 (es)
MX (1) MX2009007864A (es)
PE (1) PE20081662A1 (es)
TW (1) TW200846005A (es)
WO (1) WO2008092786A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309299B2 (en) * 2010-05-19 2012-11-13 Hoffmann-La Roche Inc. Combination therapy and method for assessing resistance to treatment
JO3148B1 (ar) * 2011-07-27 2017-09-20 Lilly Co Eli مركب مثبط لإشارات مسار notch
CN104854097A (zh) 2012-09-21 2015-08-19 百时美施贵宝公司 N-取代的二(氟烷基)-1,4-苯并二氮杂*酮化合物
JP2015529251A (ja) 2012-09-21 2015-10-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｎｏｔｃｈ阻害剤としての三環系複素環式化合物
WO2014047369A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Substituted 1,5-benzodiazepinone compounds
US9273075B2 (en) 2012-09-21 2016-03-01 Bristol-Myers Squibb Company Prodrugs of 1,4-benzodiazepinone compounds
EP2897954B1 (en) 2012-09-21 2016-10-26 Bristol-Myers Squibb Company Fluoroalkyl-1,4-benzodiazepinone compounds
WO2014047374A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds
CN104822665A (zh) 2012-09-21 2015-08-05 百时美施贵宝公司 用作Notch抑制剂的氟烷基和氟环烷基1,4-苯并二氮杂*酮化合物
EP2897938B1 (en) 2012-09-21 2017-03-15 Bristol-Myers Squibb Company Fluoroalkyl dibenzodiazepinone compounds
CN102911118B (zh) * 2012-11-09 2014-04-09 天津商业大学 一类苯并氮杂卓类衍生物及其制备方法和用途
CN105101968A (zh) 2013-04-04 2015-11-25 百时美施贵宝公司 治疗增殖性疾病的组合疗法
WO2015073524A1 (en) * 2013-11-12 2015-05-21 Drexel University Novel methods of treating or preventing alzheimer's disease
KR102130458B1 (ko) * 2015-10-30 2020-07-08 파이프라인 테라퓨틱스, 아이엔씨. 디벤조 아제핀 화합물 및 귀 질환과 귀 장애 치료에서의 그의 용도
CN109320456A (zh) * 2018-11-16 2019-02-12 天津商业大学 新晶型的抗肿瘤化合物及其制备方法和含其的组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2390892A (en) 1991-08-08 1993-03-02 Yamanouchi Pharmaceutical Co., Ltd. Urea derivative
CA2387493A1 (en) 1999-10-08 2001-04-19 Lorin Andrew Thompson Amino lactam sulfonamides as inhibitors of a.beta. protein production
CA2404023A1 (en) 2000-04-03 2001-10-11 Richard E. Olson Cyclic lactams as inhibitors of a.beta. protein production
WO2001077086A1 (en) 2000-04-11 2001-10-18 Dupont Pharmaceuticals Company SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION
GB0012671D0 (en) 2000-05-24 2000-07-19 Merck Sharp & Dohme Therapeutic agents
CN100480248C (zh) * 2003-02-04 2009-04-22 弗·哈夫曼-拉罗切有限公司 用作γ-分泌酶抑制剂的丙二酰胺衍生物
KR20070087233A (ko) * 2003-09-09 2007-08-27 에프. 호프만-라 로슈 아게 감마-세크리테이즈의 활성을 차단하는 말론아미드 유도체
DK1673347T3 (en) 2003-10-06 2015-10-12 Hoffmann La Roche SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USED AS GAMMA SECRETASE INHIBITORS
US7211573B2 (en) * 2004-12-08 2007-05-01 Hoffmann-La Roche Inc. Malonamide derivatives
CN101410378B (zh) * 2006-03-27 2012-12-05 霍夫曼-拉罗奇有限公司 作为γ分泌酶抑制剂的丙二酰胺衍生物
BRPI0717587A2 (pt) * 2006-09-20 2013-10-29 Hoffmann La Roche Derivados de 4-oxo-2,3,4,5-tetra-hidro-benzo[b][1,4]diazepina

Also Published As

Publication number Publication date
TW200846005A (en) 2008-12-01
AR065129A1 (es) 2009-05-20
AU2008209861A1 (en) 2008-08-07
US7544679B2 (en) 2009-06-09
MX2009007864A (es) 2009-07-31
IL199973A0 (en) 2010-04-15
KR20090104916A (ko) 2009-10-06
US20080188463A1 (en) 2008-08-07
CA2676160A1 (en) 2008-08-07
BRPI0807341A2 (pt) 2014-05-20
KR101150574B1 (ko) 2012-05-30
JP2010517954A (ja) 2010-05-27
EP2109604A1 (en) 2009-10-21
AU2008209861B2 (en) 2012-08-09
CN101622232A (zh) 2010-01-06
WO2008092786A1 (en) 2008-08-07
CL2008000254A1 (es) 2008-08-08

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