PE20081380A1 - Indoles - Google Patents
IndolesInfo
- Publication number
- PE20081380A1 PE20081380A1 PE2007001745A PE2007001745A PE20081380A1 PE 20081380 A1 PE20081380 A1 PE 20081380A1 PE 2007001745 A PE2007001745 A PE 2007001745A PE 2007001745 A PE2007001745 A PE 2007001745A PE 20081380 A1 PE20081380 A1 PE 20081380A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- alkyl
- indol
- alcoxy
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE INDOLES DE FORMULA (I) DONDE X ES NR7, CH2, O; Y ES C=O; O X-Y ES N=N, DONDE R7 ES H O ALQUILO(C1-C6); R1 ES H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON CN U OH, ENTRE OTROS; R2 ES H, ALCOXI(C1-C6), BENCILO, ENTRE OTROS; R3 ES H, HALOGENO O ALQUILO(C1-C6); R4 ES HALOGENO, HALO-ALCOXI(C1-C6), -O-ALQUENILO(C2-C10), ENTRE OTROS; R5 ES H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; R6 ES H, NITRO, HALOGENO, CN, ENTRE OTROS; R8, R9, R10 Y R11 SON CADA UNO H, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: {5-BROMO-2-[4-(2-OXO-2,3-DIHIDRO-BENZOIMIDAZOL-1-IL)-PIPERIDINA-1-CARBONIL]-INDOL-1-IL}-ACETONITRILO, 1-[1-(5-CLORO-1H-INDOL-2-CARBONIL)-PIPERIDIN-4-IL]-1,3-DIHIDRO-INDOL-2-ONA, (4-BENZOTRIAZOL-1-IL-PIPERIDIN-1-IL)-(5-CLORO-1H-INDOL-2-IL)-METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE VASOPRESINA V1a SIENDO UTILES EN EL TRATAMIENTO DE LA ANSIEDAD, TRASTORNOS DEPRESIVOS, DISMENORREA, HIPERTENSION, FALLO CARDIACO CRONICO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06125663 | 2006-12-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081380A1 true PE20081380A1 (es) | 2008-09-18 |
Family
ID=38983746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001745A PE20081380A1 (es) | 2006-12-08 | 2007-12-07 | Indoles |
Country Status (21)
Country | Link |
---|---|
US (4) | US7799923B2 (es) |
EP (1) | EP2089381B1 (es) |
JP (1) | JP2010511660A (es) |
KR (1) | KR101050558B1 (es) |
CN (1) | CN101541786A (es) |
AR (1) | AR064137A1 (es) |
AT (1) | ATE472544T1 (es) |
AU (1) | AU2007328994B2 (es) |
BR (1) | BRPI0720441A2 (es) |
CA (1) | CA2671324A1 (es) |
CL (1) | CL2007003503A1 (es) |
DE (1) | DE602007007512D1 (es) |
ES (1) | ES2345132T3 (es) |
IL (1) | IL198683A0 (es) |
MX (1) | MX2009005541A (es) |
NO (1) | NO20091832L (es) |
PE (1) | PE20081380A1 (es) |
RU (1) | RU2009120443A (es) |
TW (1) | TW200829570A (es) |
WO (1) | WO2008068184A1 (es) |
ZA (1) | ZA200903499B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799923B2 (en) * | 2006-12-08 | 2010-09-21 | Hoffmann-La Roche Inc. | Indoles |
AU2007328993B2 (en) * | 2006-12-08 | 2012-05-10 | F. Hoffmann-La Roche Ag | Indoles |
PE20081401A1 (es) * | 2006-12-28 | 2008-10-24 | Hoffmann La Roche | Derivados de indol como antagonistas de receptores vasopresina |
EP2199967A1 (en) * | 2008-12-08 | 2010-06-23 | Electronics and Telecommunications Research Institute | Apparatus for providing digital contents using dmb channel and method thereof |
WO2014127350A1 (en) * | 2013-02-18 | 2014-08-21 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
GB201521059D0 (en) | 2015-11-30 | 2016-01-13 | Isis Innovation | Inhibitors of metallo-beta-lactamases |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5924990B2 (ja) * | 1979-11-21 | 1984-06-13 | 協和醗酵工業株式会社 | 新規なピペリジン誘導体 |
TW199153B (es) * | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
ATE216580T1 (de) * | 1993-07-16 | 2002-05-15 | Merck & Co Inc | Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten |
CO5150201A1 (es) | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
ATE255578T1 (de) | 2000-05-12 | 2003-12-15 | Solvay Pharm Bv | Piperazin- und piperidinverbindungen |
MXPA05003948A (es) | 2002-10-17 | 2005-06-17 | Amgen Inc | Derivados de bencimidazol y su uso como ligandos de receptor vaniloide. |
SI1904477T1 (sl) | 2005-07-14 | 2009-06-30 | Hoffmann La Roche | Derivati indol-3-karbonil-spiro-piperidina kot antagonisti V1A receptorja |
PT1912976E (pt) * | 2005-07-21 | 2009-01-07 | Hoffmann La Roche | Derivados de indol-3-il-carboni-piperidin-benzimidazole como antagonistas dos receptores v1a |
RU2418801C2 (ru) * | 2005-09-28 | 2011-05-20 | Ф. Хоффманн-Ля Рош Аг | Индол-3-ил-карбонил-азаспиропроизводные в качестве антагонистов рецептора вазопрессина |
US7799923B2 (en) * | 2006-12-08 | 2010-09-21 | Hoffmann-La Roche Inc. | Indoles |
-
2007
- 2007-11-29 US US11/998,371 patent/US7799923B2/en not_active Expired - Fee Related
- 2007-11-29 MX MX2009005541A patent/MX2009005541A/es active IP Right Grant
- 2007-11-29 CA CA002671324A patent/CA2671324A1/en not_active Abandoned
- 2007-11-29 US US11/947,195 patent/US20080139618A1/en not_active Abandoned
- 2007-11-29 KR KR1020097011629A patent/KR101050558B1/ko not_active IP Right Cessation
- 2007-11-29 AU AU2007328994A patent/AU2007328994B2/en not_active Ceased
- 2007-11-29 JP JP2009539706A patent/JP2010511660A/ja active Pending
- 2007-11-29 BR BRPI0720441-8A patent/BRPI0720441A2/pt not_active IP Right Cessation
- 2007-11-29 US US11/947,146 patent/US8071622B2/en not_active Expired - Fee Related
- 2007-11-29 ES ES07847501T patent/ES2345132T3/es active Active
- 2007-11-29 DE DE602007007512T patent/DE602007007512D1/de active Active
- 2007-11-29 US US11/947,266 patent/US20080139617A1/en not_active Abandoned
- 2007-11-29 RU RU2009120443/04A patent/RU2009120443A/ru not_active Application Discontinuation
- 2007-11-29 WO PCT/EP2007/062984 patent/WO2008068184A1/en active Application Filing
- 2007-11-29 CN CNA2007800421348A patent/CN101541786A/zh active Pending
- 2007-11-29 EP EP07847501A patent/EP2089381B1/en not_active Not-in-force
- 2007-11-29 AT AT07847501T patent/ATE472544T1/de active
- 2007-12-05 AR ARP070105428A patent/AR064137A1/es unknown
- 2007-12-05 CL CL200703503A patent/CL2007003503A1/es unknown
- 2007-12-06 TW TW096146544A patent/TW200829570A/zh unknown
- 2007-12-07 PE PE2007001745A patent/PE20081380A1/es not_active Application Discontinuation
-
2009
- 2009-05-11 IL IL198683A patent/IL198683A0/en unknown
- 2009-05-11 NO NO20091832A patent/NO20091832L/no not_active Application Discontinuation
- 2009-05-20 ZA ZA200903499A patent/ZA200903499B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20080139617A1 (en) | 2008-06-12 |
US20080139618A1 (en) | 2008-06-12 |
ZA200903499B (en) | 2010-03-31 |
US7799923B2 (en) | 2010-09-21 |
EP2089381A1 (en) | 2009-08-19 |
KR101050558B1 (ko) | 2011-07-19 |
ES2345132T3 (es) | 2010-09-15 |
CN101541786A (zh) | 2009-09-23 |
AU2007328994B2 (en) | 2012-03-08 |
ATE472544T1 (de) | 2010-07-15 |
DE602007007512D1 (de) | 2010-08-12 |
JP2010511660A (ja) | 2010-04-15 |
AR064137A1 (es) | 2009-03-18 |
IL198683A0 (en) | 2010-02-17 |
US20080269290A1 (en) | 2008-10-30 |
MX2009005541A (es) | 2009-06-05 |
RU2009120443A (ru) | 2011-01-20 |
NO20091832L (no) | 2009-07-07 |
US8071622B2 (en) | 2011-12-06 |
CL2007003503A1 (es) | 2008-07-04 |
BRPI0720441A2 (pt) | 2014-01-07 |
KR20090078368A (ko) | 2009-07-17 |
EP2089381B1 (en) | 2010-06-30 |
WO2008068184A1 (en) | 2008-06-12 |
CA2671324A1 (en) | 2008-06-12 |
TW200829570A (en) | 2008-07-16 |
AU2007328994A1 (en) | 2008-06-12 |
US20080139548A1 (en) | 2008-06-12 |
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Legal Events
Date | Code | Title | Description |
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FC | Refusal |