PE20081117A1 - 4-imidazoles sustituidos - Google Patents

4-imidazoles sustituidos

Info

Publication number
PE20081117A1
PE20081117A1 PE2007001570A PE2007001570A PE20081117A1 PE 20081117 A1 PE20081117 A1 PE 20081117A1 PE 2007001570 A PE2007001570 A PE 2007001570A PE 2007001570 A PE2007001570 A PE 2007001570A PE 20081117 A1 PE20081117 A1 PE 20081117A1
Authority
PE
Peru
Prior art keywords
indol
imidazol
alkyl
compounds
ilmetil
Prior art date
Application number
PE2007001570A
Other languages
English (en)
Inventor
Guido Galley
Katrin Groebke Zbinden
Roger David Norcross
Henri Stalder
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39304662&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081117(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20081117A1 publication Critical patent/PE20081117A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 4-IMIDAZOLES SUSTITUIDOS DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C7) INFERIOR; R2 ES H O ALQUILO(C1-C7) INFERIOR; R3 ES H, ALCOXI(C1-C7) INFERIOR, FENILOXI, HALOGENO, ENTRE OTROS; R4 ES H O ALQUILO(C1-C7) INFERIOR; X ES -CH2-, -CH- U -O-; Y ES -CH2-, -CH-, -CH2CH2- O UN ENLACE; Z ES -CH2- O -CH-; m ES 1 O 2; n ES 1 O 2. SON COMPUESTOS PREFERIDOS: (RS)-1-(1H-IMIDAZOL-4-ILMETIL)-2-METIL-2,3-DIHIDRO-1H-INDOL, 1-(3H-IMIDAZOL-4-ILMETIL)-2,3-DIHIDRO-1H-INDOL, 5-BROMO-1-(1H-IMIDAZOL-4-ILMETIL)-2,3-DIHIDRO-1H-INDOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN AFINIDAD CON LOS RECEPTORES ASOCIADOS CON LAS AMINAS TRAZAS (TAAR) SIENDO UTILES EN EL TRATAMIENTO DE LA DEPRESION, LOS TRASTORNOS DE ANSIEDAD, EL TRASTORNO BIPOLAR, LA ENFERMEDAD DE PARKINSON, EPILEPSIA
PE2007001570A 2006-11-16 2007-11-14 4-imidazoles sustituidos PE20081117A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06124182 2006-11-16

Publications (1)

Publication Number Publication Date
PE20081117A1 true PE20081117A1 (es) 2008-08-15

Family

ID=39304662

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001570A PE20081117A1 (es) 2006-11-16 2007-11-14 4-imidazoles sustituidos

Country Status (18)

Country Link
US (1) US7858652B2 (es)
EP (1) EP2084152A2 (es)
JP (1) JP2010510184A (es)
KR (1) KR101134226B1 (es)
CN (1) CN101535298A (es)
AR (1) AR063811A1 (es)
AU (1) AU2007321376A1 (es)
BR (1) BRPI0718400A2 (es)
CA (1) CA2669112A1 (es)
CL (1) CL2007003275A1 (es)
IL (1) IL198469A0 (es)
MX (1) MX2009005047A (es)
NO (1) NO20091721L (es)
PE (1) PE20081117A1 (es)
RU (1) RU2456281C2 (es)
TW (1) TWI377203B (es)
WO (1) WO2008058867A2 (es)
ZA (1) ZA200903382B (es)

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US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
RU2017106928A (ru) * 2014-08-27 2018-10-01 Ф. Хоффманн-Ля Рош Аг Замещенные производные пиразино[2,1-а]изохинолина для лечения заболеваний цнс

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Also Published As

Publication number Publication date
MX2009005047A (es) 2009-05-25
WO2008058867A2 (en) 2008-05-22
KR101134226B1 (ko) 2012-04-10
US7858652B2 (en) 2010-12-28
AR063811A1 (es) 2009-02-18
WO2008058867A3 (en) 2008-07-10
IL198469A0 (en) 2010-02-17
RU2009117643A (ru) 2010-12-27
JP2010510184A (ja) 2010-04-02
ZA200903382B (en) 2010-04-28
KR20090064481A (ko) 2009-06-18
TW200831492A (en) 2008-08-01
CA2669112A1 (en) 2008-05-22
US20080139533A1 (en) 2008-06-12
CN101535298A (zh) 2009-09-16
TWI377203B (en) 2012-11-21
NO20091721L (no) 2009-07-28
RU2456281C2 (ru) 2012-07-20
CL2007003275A1 (es) 2008-06-20
EP2084152A2 (en) 2009-08-05
AU2007321376A1 (en) 2008-05-22
BRPI0718400A2 (pt) 2014-03-11

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