NO20091721L - Substituerte 4-imidazoler - Google Patents
Substituerte 4-imidazolerInfo
- Publication number
- NO20091721L NO20091721L NO20091721A NO20091721A NO20091721L NO 20091721 L NO20091721 L NO 20091721L NO 20091721 A NO20091721 A NO 20091721A NO 20091721 A NO20091721 A NO 20091721A NO 20091721 L NO20091721 L NO 20091721L
- Authority
- NO
- Norway
- Prior art keywords
- disorders
- lower alkyl
- hydrogen
- same
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår forbindelser med formel I og farmasøytisk akseptable syreaddisjonssalter. hvor. Rer hydrogen eller lavere alkyl;. er hydrogen eller lavere alkyl;. Rer hydrogen, lavere alkyl, lavere alkoksy, fenyloksy, benzyloksy, halogen eller. lavere alkyl substituert med halogen;. Rer hydrogen eller lavere alkyl;. Xer-CH2-, -CH-eller-0-;. Y er -CH-, -CHCH-, -CH- eller en binding; når X er -O-, er Y - CH-;. Zer-CH- eller -CH-;. M er 1 eller 2; når m er 2 kan Rvære det samme eller ikke det samme; N er 1 eller 2; når n er 2 kan Rvære det samme eller ikke det samme; Det er blitt oppdaget at forbindelsene med formel I har en god affinitet for sporstoff aminassosierte reseptorer (TÅAR), spesielt for TAAR1. Forbindelsene kan anvendes til behandling av depresjon, angst lidelser, bipolar lidelse, oppmerksomhets- og konsentrasjonssvikt- hyperaktivitet, uro og impulshandlinger (ADHD; "attention deficit hyperactivity disorder"), stressrelaterte lidelser, psykotiske lidelser som schizofreni, nevrologiske sykdommer som Parkinsons sykdom, neurodegenerative lidelser som Alzheimers sykdom, epilepsi, migrene, hypertensjon, stoffmisbruk og metabolske lidelser som spiseforstyrrelser, diabetes, diabetiske komplikasjoner, fedme, dyslipidemi, lidelser forbundet med energikonsum og tilpasning, lidelser og svikt i kroppens temperatur homeostase, lidelser forbundet med søvn og døgnrytme og kardiovaskulære lidelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06124182 | 2006-11-16 | ||
PCT/EP2007/061921 WO2008058867A2 (en) | 2006-11-16 | 2007-11-06 | Substituted 4-imidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20091721L true NO20091721L (no) | 2009-07-28 |
Family
ID=39304662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20091721A NO20091721L (no) | 2006-11-16 | 2009-04-30 | Substituerte 4-imidazoler |
Country Status (18)
Country | Link |
---|---|
US (1) | US7858652B2 (no) |
EP (1) | EP2084152A2 (no) |
JP (1) | JP2010510184A (no) |
KR (1) | KR101134226B1 (no) |
CN (1) | CN101535298A (no) |
AR (1) | AR063811A1 (no) |
AU (1) | AU2007321376A1 (no) |
BR (1) | BRPI0718400A2 (no) |
CA (1) | CA2669112A1 (no) |
CL (1) | CL2007003275A1 (no) |
IL (1) | IL198469A0 (no) |
MX (1) | MX2009005047A (no) |
NO (1) | NO20091721L (no) |
PE (1) | PE20081117A1 (no) |
RU (1) | RU2456281C2 (no) |
TW (1) | TWI377203B (no) |
WO (1) | WO2008058867A2 (no) |
ZA (1) | ZA200903382B (no) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200831085A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
WO2016030306A1 (en) * | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders |
Family Cites Families (59)
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US2731471A (en) | 1956-01-17 | Nxg hi | ||
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JP4108474B2 (ja) | 2000-11-14 | 2008-06-25 | エフ.ホフマン−ラ ロシュ アーゲー | Ipアンタゴニストとしての置換2−フェニルアミノイミダゾリンフェニルケトン誘導体 |
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-
2007
- 2007-11-06 WO PCT/EP2007/061921 patent/WO2008058867A2/en active Application Filing
- 2007-11-06 KR KR1020097009844A patent/KR101134226B1/ko not_active IP Right Cessation
- 2007-11-06 EP EP07847114A patent/EP2084152A2/en not_active Withdrawn
- 2007-11-06 JP JP2009536701A patent/JP2010510184A/ja active Pending
- 2007-11-06 CA CA002669112A patent/CA2669112A1/en not_active Abandoned
- 2007-11-06 MX MX2009005047A patent/MX2009005047A/es active IP Right Grant
- 2007-11-06 RU RU2009117643/04A patent/RU2456281C2/ru not_active IP Right Cessation
- 2007-11-06 AU AU2007321376A patent/AU2007321376A1/en not_active Abandoned
- 2007-11-06 BR BRPI0718400-0A patent/BRPI0718400A2/pt not_active IP Right Cessation
- 2007-11-06 CN CNA2007800425989A patent/CN101535298A/zh active Pending
- 2007-11-13 TW TW096142905A patent/TWI377203B/zh not_active IP Right Cessation
- 2007-11-13 US US11/938,801 patent/US7858652B2/en not_active Expired - Fee Related
- 2007-11-14 PE PE2007001570A patent/PE20081117A1/es not_active Application Discontinuation
- 2007-11-14 AR ARP070105059A patent/AR063811A1/es unknown
- 2007-11-14 CL CL200703275A patent/CL2007003275A1/es unknown
-
2009
- 2009-04-30 IL IL198469A patent/IL198469A0/en unknown
- 2009-04-30 NO NO20091721A patent/NO20091721L/no not_active Application Discontinuation
- 2009-05-15 ZA ZA200903382A patent/ZA200903382B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2007321376A1 (en) | 2008-05-22 |
TWI377203B (en) | 2012-11-21 |
WO2008058867A3 (en) | 2008-07-10 |
MX2009005047A (es) | 2009-05-25 |
BRPI0718400A2 (pt) | 2014-03-11 |
KR101134226B1 (ko) | 2012-04-10 |
AR063811A1 (es) | 2009-02-18 |
ZA200903382B (en) | 2010-04-28 |
RU2009117643A (ru) | 2010-12-27 |
JP2010510184A (ja) | 2010-04-02 |
US20080139533A1 (en) | 2008-06-12 |
TW200831492A (en) | 2008-08-01 |
WO2008058867A2 (en) | 2008-05-22 |
RU2456281C2 (ru) | 2012-07-20 |
CL2007003275A1 (es) | 2008-06-20 |
CN101535298A (zh) | 2009-09-16 |
CA2669112A1 (en) | 2008-05-22 |
KR20090064481A (ko) | 2009-06-18 |
EP2084152A2 (en) | 2009-08-05 |
IL198469A0 (en) | 2010-02-17 |
PE20081117A1 (es) | 2008-08-15 |
US7858652B2 (en) | 2010-12-28 |
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