PE20080844A1 - Uso de moduladores lxr para la prevencion y tratamiento del envejecimiento de la piel - Google Patents

Uso de moduladores lxr para la prevencion y tratamiento del envejecimiento de la piel

Info

Publication number
PE20080844A1
PE20080844A1 PE2007001262A PE2007001262A PE20080844A1 PE 20080844 A1 PE20080844 A1 PE 20080844A1 PE 2007001262 A PE2007001262 A PE 2007001262A PE 2007001262 A PE2007001262 A PE 2007001262A PE 20080844 A1 PE20080844 A1 PE 20080844A1
Authority
PE
Peru
Prior art keywords
lxr
prevention
treatment
skin aging
oxisterol
Prior art date
Application number
PE2007001262A
Other languages
English (en)
Inventor
Sunil Nagpal
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080844A1 publication Critical patent/PE20080844A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN MODULADOR LXR SELECCIONADO DE OXISTEROL, NO-OXISTEROL (NATURAL O SINTETICO), 22(R)HIDROXICOLESTEROL, N-(2,2,2-TRIFLUOROETIL)-N-{4-[2,2,2-TRIFLUORO-1-HIDROXI-1-(TRIFLUOROMETIL)ETIL]FENIL}BENCENO SULFONAMIDA, ENTRE OTROS. OPCIONALMENTE PUEDE CONTENER O NO UN LIGANDO, COMO, ACIDO ALL-TRANS RETINOICO, ACIDO 6-[3-(1-ADAMANTIL)-4-METOXIFENIL]-2-NAFTOICO, ENTRE OTROS; UN ANTIOXIDANTE; FILTRO SOLAR; RETINOIDES, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. EL MODULADOR DE LXR, INDUCE A LA EXPRESION DE LXR , LXRß, TIMP1, ASAH1, ENTRE OTROS, POR LO QUE DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO ANTI-ENVEJECIMIENTO DE LA PIEL
PE2007001262A 2006-09-19 2007-09-19 Uso de moduladores lxr para la prevencion y tratamiento del envejecimiento de la piel PE20080844A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84568506P 2006-09-19 2006-09-19

Publications (1)

Publication Number Publication Date
PE20080844A1 true PE20080844A1 (es) 2008-08-15

Family

ID=39110878

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001262A PE20080844A1 (es) 2006-09-19 2007-09-19 Uso de moduladores lxr para la prevencion y tratamiento del envejecimiento de la piel

Country Status (5)

Country Link
US (1) US20080070883A1 (es)
AR (1) AR062911A1 (es)
PE (1) PE20080844A1 (es)
TW (1) TW200819145A (es)
WO (1) WO2008036238A2 (es)

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AU2007339325A1 (en) * 2006-12-19 2008-07-10 The Regents Of The University Of California Inhibition of PPAR gamma expression by specific osteogenic oxysterols
EP2146724A2 (en) * 2007-03-16 2010-01-27 The Regent of the University of California Role of hedgehog signaling in atherosclerosis and cardiovascular disease
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CA2698928A1 (en) * 2007-09-28 2009-04-09 Absolute Science, Inc. Compounds and methods for treating zinc matrix metalloprotease dependent diseases
US9526737B2 (en) * 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
CN101945871A (zh) * 2007-12-21 2011-01-12 惠氏有限责任公司 咪唑并[1，2-a]吡啶化合物
WO2009086130A1 (en) * 2007-12-21 2009-07-09 Wyeth Imidazo [1,2-b] pyridazine compounds as modulators of liver x receptors
CA2710461A1 (en) * 2007-12-21 2009-07-09 Wyeth Llc Benzimidazole compounds
JP2011507901A (ja) * 2007-12-21 2011-03-10 ワイス・エルエルシー ピラゾロ［１，５−ａ］ピリミジン化合物
JP2011520451A (ja) 2008-05-14 2011-07-21 ダームテック インターナショナル 核酸解析による黒色腫および日光黒子の診断法
WO2010033360A1 (en) * 2008-09-19 2010-03-25 1/3 Absolute Science, Inc. Methods of treating a botulinum toxin related condition in a subject
WO2010062762A2 (en) * 2008-11-03 2010-06-03 Dermachip Inc. Compositions and methods for reducing the signs of aging of the skin
JP2012508250A (ja) * 2008-11-07 2012-04-05 ワイス・エルエルシー キノキサリン系のｌｘｒモジュレーター
WO2010059627A1 (en) * 2008-11-19 2010-05-27 Wyeth Llc Polar quinazolines as liver x receptors ( lxrs ) modulators
WO2011006087A1 (en) * 2009-07-10 2011-01-13 The Regents Of The University Of California Inhibition of ppar gamma expression in preadipocyte cells by oxysterols
KR101766393B1 (ko) * 2010-11-30 2017-08-10 (주)아모레퍼시픽 블레오마이신 하이드로라제를 이용한 건조 피부 개선물질 스크리닝 방법
US20140080920A1 (en) * 2011-05-17 2014-03-20 Chanel Parfums Beaute Large, hs6st2 or st8sia1 activators for preventing and/or attenuating skin ageing and/or hydrating skin
AU2012348700B2 (en) 2011-12-06 2015-08-27 Unilever Plc Skin anti-ageing composition
JP6262723B2 (ja) 2012-05-07 2018-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ オキシステロールアナログｏｘｙ１３３は、骨発生及びヘッジホッグシグナル伝達を誘導し、脂肪生成を阻害する
AU2014259672A1 (en) 2013-05-02 2015-12-03 The Regents Of The University Of California Bone-selective osteogenic oxysterol-bone targeting agents
CN105132358B (zh) * 2015-07-29 2019-12-06 苏州诺普再生医学有限公司 培养获得组织工程表皮的方法及其应用
EP3397258A2 (en) * 2015-12-30 2018-11-07 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (CONICET) Use of brassinosteroid analogs for the treatment of dermal disorders by selectively modulating liver x receptors (lxr) and dermal disease treatment by brassinosteroid analogs acting as selective liver x receptor (lxr) modulators
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EP3948290A4 (en) 2019-03-26 2023-08-09 Dermtech, Inc. NEW GENE CLASSIFIERS AND THEIR USES FOR SKIN CANCERS
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Also Published As

Publication number Publication date
AR062911A1 (es) 2008-12-17
WO2008036238A3 (en) 2011-08-11
WO2008036238A2 (en) 2008-03-27
US20080070883A1 (en) 2008-03-20
TW200819145A (en) 2008-05-01

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