PE20080380A1 - Sales de 2-(metiloxi)-n-[2-metil-1-fenil-2-(1-pirrolidinil)propil]-4,6-bis(trifluorometil)benzamida que tienen actividad en el transportador glyt1 - Google Patents
Sales de 2-(metiloxi)-n-[2-metil-1-fenil-2-(1-pirrolidinil)propil]-4,6-bis(trifluorometil)benzamida que tienen actividad en el transportador glyt1Info
- Publication number
- PE20080380A1 PE20080380A1 PE2007000782A PE2007000782A PE20080380A1 PE 20080380 A1 PE20080380 A1 PE 20080380A1 PE 2007000782 A PE2007000782 A PE 2007000782A PE 2007000782 A PE2007000782 A PE 2007000782A PE 20080380 A1 PE20080380 A1 PE 20080380A1
- Authority
- PE
- Peru
- Prior art keywords
- methyloxy
- pyrrolidinyl
- trifluoromethyl
- propyl
- bis
- Prior art date
Links
- NGWVYOWTXSIDQF-UHFFFAOYSA-N 2-methoxy-n-(2-methyl-1-phenyl-2-pyrrolidin-1-ylpropyl)-4,6-bis(trifluoromethyl)benzamide Chemical class COC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1C(=O)NC(C(C)(C)N1CCCC1)C1=CC=CC=C1 NGWVYOWTXSIDQF-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 102100022622 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Human genes 0.000 title 1
- 101000972916 Homo sapiens Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Proteins 0.000 title 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- -1 NAPADISILATE Chemical compound 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 101710083171 Sodium- and chloride-dependent glycine transporter 1 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229950005216 napadisilate Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0612420.0A GB0612420D0 (en) | 2006-06-22 | 2006-06-22 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080380A1 true PE20080380A1 (es) | 2008-05-31 |
Family
ID=36803732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000782A PE20080380A1 (es) | 2006-06-22 | 2007-06-20 | Sales de 2-(metiloxi)-n-[2-metil-1-fenil-2-(1-pirrolidinil)propil]-4,6-bis(trifluorometil)benzamida que tienen actividad en el transportador glyt1 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20080070973A1 (enExample) |
| EP (1) | EP2041082B1 (enExample) |
| JP (1) | JP2009541261A (enExample) |
| KR (1) | KR20090019847A (enExample) |
| CN (1) | CN101506156A (enExample) |
| AR (1) | AR061554A1 (enExample) |
| AT (1) | ATE444288T1 (enExample) |
| AU (1) | AU2007263058A1 (enExample) |
| BR (1) | BRPI0713311A2 (enExample) |
| CA (1) | CA2655399A1 (enExample) |
| CL (1) | CL2007001808A1 (enExample) |
| CR (1) | CR10498A (enExample) |
| DE (1) | DE602007002642D1 (enExample) |
| EA (1) | EA200970044A1 (enExample) |
| ES (1) | ES2333918T3 (enExample) |
| GB (1) | GB0612420D0 (enExample) |
| IL (1) | IL195633A0 (enExample) |
| MA (1) | MA30522B1 (enExample) |
| NO (1) | NO20085412L (enExample) |
| PE (1) | PE20080380A1 (enExample) |
| TW (1) | TW200817322A (enExample) |
| WO (1) | WO2007147831A1 (enExample) |
| ZA (1) | ZA200810009B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| US20100184996A1 (en) * | 2007-06-20 | 2010-07-22 | Glaxo Group Limited | Process of amide formation |
| US9045445B2 (en) | 2010-06-04 | 2015-06-02 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US20120035156A1 (en) * | 2010-08-09 | 2012-02-09 | Daniela Alberati | Combination of glyt1 compound with antipsychotics |
| JP7152122B2 (ja) | 2017-10-13 | 2022-10-12 | ツリーウェイ ティーダブリュー００１ ビー．ブイ． | エダラボン塩 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2746959A (en) * | 1953-06-02 | 1956-05-22 | American Home Prod | Diphenylethylenediamine-penicillin salt |
| US3145209A (en) * | 1961-07-31 | 1964-08-18 | Olin Mathieson | Substituted aminophenyl-ethylamine derivatives |
| NZ237443A (en) * | 1990-04-10 | 1993-11-25 | Asta Medica Ag | Phenalkylethylenediamine and aminomethyltetra hydroisoquinoline derivatives, platinum (ii) and (iv) complexes, methods of preparation and pharmaceutical compositions |
| GB0130696D0 (en) * | 2001-12-21 | 2002-02-06 | Smithkline Beecham Plc | Chemical Compounds |
| FR2861070B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique |
| PE20061156A1 (es) * | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
-
2006
- 2006-06-22 GB GBGB0612420.0A patent/GB0612420D0/en not_active Ceased
-
2007
- 2007-06-20 AU AU2007263058A patent/AU2007263058A1/en not_active Abandoned
- 2007-06-20 TW TW096121972A patent/TW200817322A/zh unknown
- 2007-06-20 KR KR1020087030915A patent/KR20090019847A/ko not_active Withdrawn
- 2007-06-20 DE DE602007002642T patent/DE602007002642D1/de active Active
- 2007-06-20 EA EA200970044A patent/EA200970044A1/ru unknown
- 2007-06-20 WO PCT/EP2007/056106 patent/WO2007147831A1/en not_active Ceased
- 2007-06-20 US US11/765,478 patent/US20080070973A1/en not_active Abandoned
- 2007-06-20 PE PE2007000782A patent/PE20080380A1/es not_active Application Discontinuation
- 2007-06-20 JP JP2009515863A patent/JP2009541261A/ja not_active Withdrawn
- 2007-06-20 BR BRPI0713311-1A patent/BRPI0713311A2/pt not_active IP Right Cessation
- 2007-06-20 AR ARP070102723A patent/AR061554A1/es unknown
- 2007-06-20 CA CA002655399A patent/CA2655399A1/en not_active Abandoned
- 2007-06-20 AT AT07786764T patent/ATE444288T1/de not_active IP Right Cessation
- 2007-06-20 CL CL2007001808A patent/CL2007001808A1/es unknown
- 2007-06-20 EP EP07786764A patent/EP2041082B1/en active Active
- 2007-06-20 ES ES07786764T patent/ES2333918T3/es active Active
- 2007-06-20 CN CNA2007800312340A patent/CN101506156A/zh active Pending
-
2008
- 2008-11-25 ZA ZA200810009A patent/ZA200810009B/xx unknown
- 2008-12-01 IL IL195633A patent/IL195633A0/en unknown
- 2008-12-11 CR CR10498A patent/CR10498A/es not_active Application Discontinuation
- 2008-12-19 MA MA31488A patent/MA30522B1/fr unknown
- 2008-12-30 NO NO20085412A patent/NO20085412L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR061554A1 (es) | 2008-09-03 |
| DE602007002642D1 (de) | 2009-11-12 |
| EA200970044A1 (ru) | 2009-04-28 |
| CL2007001808A1 (es) | 2008-01-18 |
| ES2333918T3 (es) | 2010-03-02 |
| JP2009541261A (ja) | 2009-11-26 |
| EP2041082B1 (en) | 2009-09-30 |
| WO2007147831A1 (en) | 2007-12-27 |
| CR10498A (es) | 2009-03-20 |
| MA30522B1 (fr) | 2009-06-01 |
| BRPI0713311A2 (pt) | 2012-03-06 |
| TW200817322A (en) | 2008-04-16 |
| KR20090019847A (ko) | 2009-02-25 |
| CA2655399A1 (en) | 2007-12-27 |
| NO20085412L (no) | 2009-01-22 |
| EP2041082A1 (en) | 2009-04-01 |
| AU2007263058A1 (en) | 2007-12-27 |
| GB0612420D0 (en) | 2006-08-02 |
| ATE444288T1 (de) | 2009-10-15 |
| ZA200810009B (en) | 2009-11-25 |
| US20080070973A1 (en) | 2008-03-20 |
| IL195633A0 (en) | 2009-09-01 |
| CN101506156A (zh) | 2009-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |