PE20070816A1 - Compuestos derivados de 2-carbamida-4-feniltiazol como moduladores de los receptores de las quimiocinas - Google Patents

Compuestos derivados de 2-carbamida-4-feniltiazol como moduladores de los receptores de las quimiocinas

Info

Publication number
PE20070816A1
PE20070816A1 PE2007000013A PE2007000013A PE20070816A1 PE 20070816 A1 PE20070816 A1 PE 20070816A1 PE 2007000013 A PE2007000013 A PE 2007000013A PE 2007000013 A PE2007000013 A PE 2007000013A PE 20070816 A1 PE20070816 A1 PE 20070816A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyltiazole
carbamide
modulators
metoxy
Prior art date
Application number
PE2007000013A
Other languages
English (en)
Inventor
Pierre Fraisse
Pierre Casellas
Daniel Floutard
Stephane Hourcade
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20070816A1 publication Critical patent/PE20070816A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 2-CARBAMIDA-4-FENILTIAZOL DE FORMULA (I) DONDE R1 ES H, HALOGENO, ALQUILO(C1-C8), OH, ENTRE OTROS; R2 ES H, HALOGENO, CICLOALQUILO(C3-C10), -O-ALQUILO(C1-C8), ENTRE OTROS; Y ES H O HALOGENO; p ES 2 O 3; R3 ES UN GRUPO DE FORMULA -(CH2)a-A, -CO(CH2)b-A, ENTRE OTROS, DONDE a ES DE 1 A 4; b ES DE 0 A 4; A ES UN COMPUESTO DE FORMULA (a), (b), (c), ENTRE OTROS, DONDE R7 ES ALQUIL(C1-C8)-COO-ALQUILO(C1-C8), -CO-ALQUILO(C1-C8), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [4-(5-CICLOHEXIL-2-METOXI-FENIL)-TIAZOL-2-IL]-AMIDA DEL ACIDO 4-((S)-1-CICLOPROPIL-PIPERIDIN-3-ILMETIL)-PIPERAZINA-1-CARBOXILICO, [4-(5-CICLOHEXIL-2-METOXI-FENIL)-TIAZOL-2-IL]-AMIDA DEL ACIDO 4-(1-ISOPROPILCARBAMOIL-PIPERIDIN-3-IL)-PIPERAZINA-1-CARBOXILICO, [4-(5-CICLOHEXIL-2-METOXI-FENIL)-TIAZOL-2-IL]-AMIDA DEL ACIDO 4-(1-CICLOPROPANOSULFONIL-PIPERIDIN-4-IL)-PIPERAZINA-1-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DE LA ACTIVIDAD DE LOS RECEPTORES DE LAS QUIMIOCINAS SIENDO UTILES PARA EL TRATAMIENTO DE ATEROSCLEROSIS, RESTENOSIS, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, FIBROSIS PULMONAR
PE2007000013A 2006-01-06 2007-01-05 Compuestos derivados de 2-carbamida-4-feniltiazol como moduladores de los receptores de las quimiocinas PE20070816A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0600117A FR2895989B1 (fr) 2006-01-06 2006-01-06 Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20070816A1 true PE20070816A1 (es) 2007-08-17

Family

ID=36940477

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000013A PE20070816A1 (es) 2006-01-06 2007-01-05 Compuestos derivados de 2-carbamida-4-feniltiazol como moduladores de los receptores de las quimiocinas

Country Status (23)

Country Link
US (1) US7825112B2 (es)
EP (1) EP1984361A1 (es)
JP (1) JP2009525951A (es)
KR (1) KR20080082970A (es)
CN (1) CN101365698A (es)
AP (1) AP2008004568A0 (es)
AR (1) AR059129A1 (es)
AU (1) AU2007203998A1 (es)
BR (1) BRPI0706305A2 (es)
CA (1) CA2632854A1 (es)
CR (1) CR10098A (es)
DO (1) DOP2007000004A (es)
EA (1) EA200870157A1 (es)
EC (1) ECSP088574A (es)
FR (1) FR2895989B1 (es)
GT (1) GT200700002A (es)
IL (1) IL191892A0 (es)
MA (1) MA30179B1 (es)
NO (1) NO20083352L (es)
PE (1) PE20070816A1 (es)
TN (1) TNSN08242A1 (es)
TW (1) TW200738703A (es)
WO (1) WO2007077394A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854158B1 (fr) 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2876692B1 (fr) 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2406634A1 (fr) * 1977-10-19 1979-05-18 Fabre Sa Pierre Immunostimulants derives d'amino thiazoles
WO1987001706A2 (en) 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
FR2677356B1 (fr) 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
JPH07502014A (ja) * 1991-06-21 1995-03-02 ベーリンガー　マンハイム　イタリア　エス．ピー．エイ． 気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール
US6506751B1 (en) * 1999-11-12 2003-01-14 Millennium Pharmaceuticals, Inc. Thiazolidinone compounds useful as chemokine inhibitors
US6852752B2 (en) * 1999-12-17 2005-02-08 Vicuron Pharmaceuticals Inc. Urea compounds, compositions and methods of use and preparation
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
CA2432713C (en) * 2000-12-22 2009-10-27 Ishihara Sangyo Kaisha, Ltd. Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
US7265134B2 (en) 2001-08-17 2007-09-04 Merck & Co., Inc. Tyrosine kinase inhibitors
US7157452B2 (en) 2001-12-31 2007-01-02 Mgi Gp, Inc. Substituted 4,9-dihydrocyclopenta{imn}phenanthridine-5-ones derivatives thereof and their uses
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
JPWO2003104230A1 (ja) 2002-06-07 2005-10-06 協和醗酵工業株式会社 二環性ピリミジン誘導体
FR2854158B1 (fr) * 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
FR2872813B1 (fr) * 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2876692B1 (fr) 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
NZ555770A (en) * 2004-12-24 2010-12-24 Astrazeneca Ab Heterocyclic piperazine-carboxamide compounds as CCR2B antagonists
US8173638B2 (en) * 2006-11-21 2012-05-08 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor

Also Published As

Publication number Publication date
TNSN08242A1 (en) 2009-10-30
FR2895989A1 (fr) 2007-07-13
EA200870157A1 (ru) 2009-12-30
GT200700002A (es) 2007-08-20
FR2895989B1 (fr) 2010-04-30
AP2008004568A0 (en) 2008-08-31
TW200738703A (en) 2007-10-16
US7825112B2 (en) 2010-11-02
IL191892A0 (en) 2008-12-29
DOP2007000004A (es) 2007-07-31
AR059129A1 (es) 2008-03-12
KR20080082970A (ko) 2008-09-12
BRPI0706305A2 (pt) 2011-03-22
WO2007077394A1 (fr) 2007-07-12
AU2007203998A1 (en) 2007-07-12
NO20083352L (no) 2008-07-30
CN101365698A (zh) 2009-02-11
CA2632854A1 (fr) 2007-07-12
CR10098A (es) 2008-11-26
US20090018117A1 (en) 2009-01-15
EP1984361A1 (fr) 2008-10-29
ECSP088574A (es) 2008-07-30
MA30179B1 (fr) 2009-01-02
JP2009525951A (ja) 2009-07-16

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