PE20060944A1 - Formulaciones de derivados de [1,4]diazepina [6,7,1-ij]quinolina - Google Patents
Formulaciones de derivados de [1,4]diazepina [6,7,1-ij]quinolinaInfo
- Publication number
- PE20060944A1 PE20060944A1 PE2005001293A PE2005001293A PE20060944A1 PE 20060944 A1 PE20060944 A1 PE 20060944A1 PE 2005001293 A PE2005001293 A PE 2005001293A PE 2005001293 A PE2005001293 A PE 2005001293A PE 20060944 A1 PE20060944 A1 PE 20060944A1
- Authority
- PE
- Peru
- Prior art keywords
- composition
- weight
- component based
- diazepine
- alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO DE FORMULA (I) DONDE R1 ES H, ALCANOILO(C2-C6), ENTRE OTROS; R2 Y R3 SON OH, ALCOXI(C1-C6), ENTRE OTROS; R4 Y R5 SON ALQUILO(C1-C6); R6 Y R7 SON ALQUILO(C1-C6); n ES 1 O 2 Y UNA LINEA PUNTEADA REPRESENTA UN DOBLE ENLACE OPCIONAL. UN COMPUESTO PREFERIDO ES CLORHIDRATO (9aR,12aS)-4,5,6,7,9,9a,10,11,12,12a-DECAHIDROCICLOPENTA[c][1,4]DIAZEPINA[6,7,1-ij]QUINOLINA. DICHA COMPOSICION COMPRENDE: A) DE 10% A 80% EN PESO DE LA COMPOSICION DE UN PRINCIPIO ACTIVO DE FORMULA (I); B) DE 10% A 80% EN PESO DE LA COMPOSICION DE UN COMPONENTE DE RELLENO A BASE DE LACTOSA, ALMIDON; C) DE 0,01% A 5% EN PESO DE LA COMPOSICION DE UN COMPONENTE DE RECUBRIMIENTO Y SELLADO A BASE DE CELULOSA; D) DE 0,01% A 20% EN PESO DE LA COMPOSICION DE UN COMPONENTE DE RECUBRIMIENTO ENTERICO A BASE DE POLIMERO SECO, ACRILATO-METACRILATO; E) DE 0.01% A 20% EN PESO DE LA COMPOSICION DE UN DESLIZANTE A BASE DE TALCO, DIOXIDO DE SILICONA; F) DE 0.01% A 3% EN PESO DE LA COMPOSICION DE UN PLASTIFICANTE TALES COMO TRIETIL CITRATO, SORBITOL; G) DE 0.01% A 1,5% EN PESO DE LA COMPOSICION DE UN NEUTRALIZADOR TAL COMO NAOH; H) DE 0.001% A 1% EN PESO DE LA COMPOSICION DE UN TENSOACTIVO TAL COMO POLISORBATO 80 Y I) DE 0.01% A 5% EN PESO DE LA COMPOSICION DE UN LUBRICANTE TAL COMO ACEITE VEGETAL. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LA ESQUIZOFRENIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62528004P | 2004-11-05 | 2004-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060944A1 true PE20060944A1 (es) | 2006-10-27 |
Family
ID=35841773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005001293A PE20060944A1 (es) | 2004-11-05 | 2005-11-03 | Formulaciones de derivados de [1,4]diazepina [6,7,1-ij]quinolina |
Country Status (19)
Country | Link |
---|---|
US (1) | US20060110451A1 (es) |
EP (1) | EP1807088A1 (es) |
JP (1) | JP2008519057A (es) |
KR (1) | KR20070084010A (es) |
CN (1) | CN101094675A (es) |
AR (1) | AR051946A1 (es) |
AU (1) | AU2005304758A1 (es) |
BR (1) | BRPI0517060A (es) |
CA (1) | CA2586124A1 (es) |
GT (1) | GT200500318A (es) |
IL (1) | IL182800A0 (es) |
MX (1) | MX2007005478A (es) |
NO (1) | NO20072169L (es) |
PE (1) | PE20060944A1 (es) |
RU (1) | RU2007114079A (es) |
SV (1) | SV2006002293A (es) |
TW (1) | TW200630100A (es) |
WO (1) | WO2006052887A1 (es) |
ZA (1) | ZA200703623B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
WO2007112014A2 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | New therapeutic combinations for the treatment of depression |
PA8720401A1 (es) * | 2006-03-24 | 2008-12-18 | Wyeth Corp | Metodos para tratar trastornos cognitivos y otros afines |
AU2007230997A1 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Treatment of pain |
EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
CA2962959C (en) * | 2014-10-08 | 2023-04-04 | Synthetic Biologics, Inc. | Beta-lactamase formulations and uses thereof |
US10945974B2 (en) | 2015-06-01 | 2021-03-16 | Xeno Biosciences Inc. | Methods and compositions to modulate the gut microbiota and to manage weight |
CN105920017B (zh) * | 2016-06-08 | 2018-06-05 | 广州嘉德乐生化科技有限公司 | 一种治疗单纯性肥胖症的药物组合物及其用途 |
AU2017368074A1 (en) * | 2016-11-30 | 2019-06-13 | Xeno Biosciences Inc. | Pharmaceutical preparations and methods to manage weight and to modulate the gut microbiota |
WO2019131902A1 (ja) | 2017-12-27 | 2019-07-04 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
CN111743976A (zh) * | 2020-07-03 | 2020-10-09 | 广西医科大学 | 一种二氧化硅气凝胶在制备治疗骨关节炎药物中的应用 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3158619A (en) * | 1962-06-14 | 1964-11-24 | Searle & Co | Certain sulfur-containing ortho-fused polycyclic pyrazole derivatives |
US3235564A (en) * | 1964-03-27 | 1966-02-15 | Searle & Co | Intermediates to certain sulfur-containing ortho-fused polycyclic pyrazole derivatives |
US3296252A (en) * | 1964-04-02 | 1967-01-03 | Sandoz Ag | Tetracyclic diazepinone compounds |
US3335134A (en) * | 1964-04-02 | 1967-08-08 | Sandoz Ag | Certain 3, 4-dihydrofluoreno[1, 9a, 9-e, f]1, 4-diazepin-3(2h)-ones |
GB1120463A (en) * | 1964-07-06 | 1968-07-17 | Manuf Prod Pharma | Derivatives of 1,3-diazafluoranthene-1-oxide |
US3417101A (en) * | 1964-11-09 | 1968-12-17 | American Home Prod | Fused ring compounds |
US3329676A (en) * | 1964-11-09 | 1967-07-04 | American Home Prod | Fused 1, 4-diazepine ring systems |
US3714149A (en) * | 1969-11-03 | 1973-01-30 | Upjohn Co | Pyridobenzodiazepinones |
US3914250A (en) * | 1974-08-01 | 1975-10-21 | American Home Prod | 1,4-Diazepino{8 6,5,4-jk{9 carbazoles |
US4880814A (en) * | 1987-11-13 | 1989-11-14 | Abbott Laboratories | 7-cycloalkyl naphthyridines |
GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
EP0357417A1 (en) * | 1988-09-01 | 1990-03-07 | Glaxo Group Limited | Lactam derivatives |
NZ314105A (en) * | 1996-02-02 | 1997-12-19 | Sumitomo Pharma | Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring |
US6380166B1 (en) * | 1999-09-13 | 2002-04-30 | American Home Products Corporation | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols |
US6761904B2 (en) * | 2000-03-31 | 2004-07-13 | Nycomed Austria Gmbh | Pharmaceutical kit comprising midodrine as active drug substance |
AR031197A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de derivados de 1,2,3,4,8,9,10,10a-octahidro-7bh-ciclopenta(b) diazepino(6,7,1-hi)indol |
AR031196A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de ciclopenta (b) (1,4)-diazepino (6,7,1-hi) indoles y derivados |
AR031199A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados |
AR031202A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
AR031200A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
US6414144B1 (en) * | 2000-11-03 | 2002-07-02 | Wyeth | Process for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi] indole derivatives |
US6503900B2 (en) * | 2000-11-03 | 2003-01-07 | Wyeth | [1,4]diazepino [6,7,1-jk ]carbazoles and derivatives |
US6916922B2 (en) * | 2000-11-03 | 2005-07-12 | Wyeth | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives |
CA2432185C (en) * | 2000-12-20 | 2011-11-08 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
CA2453219A1 (en) * | 2001-08-06 | 2003-02-20 | Pharmacia & Upjohn Company | Therapeutically useful tetracyclic ligands |
TW200307682A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
TWI312781B (en) * | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
TW200307540A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
EP1581221B1 (en) * | 2002-12-19 | 2011-05-18 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
EP1592453A1 (en) * | 2003-01-28 | 2005-11-09 | Collegium Pharmaceutical, Inc. | Multiparticulate compositions of milnacipran for oral administration |
TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
PA8720401A1 (es) * | 2006-03-24 | 2008-12-18 | Wyeth Corp | Metodos para tratar trastornos cognitivos y otros afines |
-
2005
- 2005-11-01 AR ARP050104612A patent/AR051946A1/es unknown
- 2005-11-03 TW TW094138588A patent/TW200630100A/zh unknown
- 2005-11-03 PE PE2005001293A patent/PE20060944A1/es not_active Application Discontinuation
- 2005-11-04 RU RU2007114079/15A patent/RU2007114079A/ru not_active Application Discontinuation
- 2005-11-04 MX MX2007005478A patent/MX2007005478A/es unknown
- 2005-11-04 BR BRPI0517060-5A patent/BRPI0517060A/pt not_active IP Right Cessation
- 2005-11-04 WO PCT/US2005/040290 patent/WO2006052887A1/en active Application Filing
- 2005-11-04 CA CA002586124A patent/CA2586124A1/en not_active Abandoned
- 2005-11-04 JP JP2007540135A patent/JP2008519057A/ja active Pending
- 2005-11-04 AU AU2005304758A patent/AU2005304758A1/en not_active Abandoned
- 2005-11-04 CN CNA2005800457406A patent/CN101094675A/zh not_active Withdrawn
- 2005-11-04 KR KR1020077010290A patent/KR20070084010A/ko not_active Application Discontinuation
- 2005-11-04 EP EP05824164A patent/EP1807088A1/en not_active Withdrawn
- 2005-11-04 GT GT200500318A patent/GT200500318A/es unknown
- 2005-11-04 SV SV2005002293A patent/SV2006002293A/es unknown
- 2005-11-04 US US11/267,605 patent/US20060110451A1/en not_active Abandoned
-
2007
- 2007-04-26 NO NO20072169A patent/NO20072169L/no not_active Application Discontinuation
- 2007-04-26 IL IL182800A patent/IL182800A0/en unknown
- 2007-05-04 ZA ZA200703623A patent/ZA200703623B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007005478A (es) | 2007-05-24 |
SV2006002293A (es) | 2006-10-13 |
US20060110451A1 (en) | 2006-05-25 |
TW200630100A (en) | 2006-09-01 |
AR051946A1 (es) | 2007-02-21 |
WO2006052887A1 (en) | 2006-05-18 |
CN101094675A (zh) | 2007-12-26 |
JP2008519057A (ja) | 2008-06-05 |
BRPI0517060A (pt) | 2008-09-30 |
EP1807088A1 (en) | 2007-07-18 |
NO20072169L (no) | 2007-07-24 |
RU2007114079A (ru) | 2008-12-10 |
KR20070084010A (ko) | 2007-08-24 |
IL182800A0 (en) | 2007-09-20 |
GT200500318A (es) | 2006-06-13 |
CA2586124A1 (en) | 2006-05-18 |
AU2005304758A1 (en) | 2006-05-18 |
ZA200703623B (en) | 2009-10-28 |
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