PE20060723A1 - Derivados de morfina como agentes analgesicos - Google Patents
Derivados de morfina como agentes analgesicosInfo
- Publication number
- PE20060723A1 PE20060723A1 PE2005001291A PE2005001291A PE20060723A1 PE 20060723 A1 PE20060723 A1 PE 20060723A1 PE 2005001291 A PE2005001291 A PE 2005001291A PE 2005001291 A PE2005001291 A PE 2005001291A PE 20060723 A1 PE20060723 A1 PE 20060723A1
- Authority
- PE
- Peru
- Prior art keywords
- alcoxy
- morphinan
- ona
- cyclopropylmethyl
- dihydroxy
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004320583 | 2004-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060723A1 true PE20060723A1 (es) | 2006-08-29 |
Family
ID=36319248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001291A PE20060723A1 (es) | 2004-11-04 | 2005-11-03 | Derivados de morfina como agentes analgesicos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8470845B2 (enExample) |
| EP (1) | EP1820505A4 (enExample) |
| JP (1) | JP4706636B2 (enExample) |
| KR (1) | KR101285645B1 (enExample) |
| CN (1) | CN101090722B (enExample) |
| AR (1) | AR053098A1 (enExample) |
| CA (1) | CA2586181C (enExample) |
| MX (1) | MX2007005336A (enExample) |
| NO (1) | NO20072832L (enExample) |
| PE (1) | PE20060723A1 (enExample) |
| TW (1) | TW200621785A (enExample) |
| WO (1) | WO2006049248A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200806294A (en) * | 2005-11-09 | 2008-02-01 | Toray Industries | Therapeutic or prophylactic agent for functional intestinal injury |
| CA2634055C (en) | 2005-12-21 | 2011-07-05 | Toray Industries, Inc. | Antitussive agent |
| FR2902341B1 (fr) | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
| FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
| CA2687956C (en) * | 2007-05-21 | 2015-03-31 | Toray Industries, Inc. | Method for producing pharmaceutical tablet |
| WO2008143240A1 (ja) * | 2007-05-21 | 2008-11-27 | Toray Industries, Inc. | 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法 |
| JP5564943B2 (ja) * | 2007-05-21 | 2014-08-06 | 東レ株式会社 | 結晶性微粉化粒子 |
| FR2930447B1 (fr) | 2008-04-25 | 2010-07-30 | Sod Conseils Rech Applic | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique |
| CA3091752A1 (en) | 2018-03-08 | 2019-09-12 | Victoria Link Ltd | Treatment of demyelinating diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4118823B1 (enExample) * | 1964-02-03 | 1966-10-31 | ||
| US3318886A (en) * | 1965-07-21 | 1967-05-09 | American Cyanamid Co | Substituted 7-hydroxymethyl-7, 8-dihydro-6-amino-6, 14-endoethenocodides and morphide |
| NL8102558A (nl) * | 1981-05-25 | 1982-12-16 | Alcoa Nederland Bv | Lichtmast met versterking van de opening in het onderste gedeelte. |
| JP2525552B2 (ja) * | 1992-01-23 | 1996-08-21 | 東レ株式会社 | モルヒナン誘導体および医薬用途 |
| NZ268969A (en) | 1993-07-23 | 1997-06-24 | Toray Industries | Morphinan derivatives and pharmaceutical compositions |
| JP3348230B2 (ja) | 1995-03-03 | 2002-11-20 | アルゴス ファーマシューティカル コーポレーション | 尿失禁の治療用のデキシトルメトルファン又はデキシトルオルファンの使用 |
| AU6020300A (en) | 1999-07-19 | 2001-02-05 | Toray Industries, Inc. | Remedies or preventives for frequent urination or urinary incontinence |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| ATE292625T1 (de) | 2000-10-31 | 2005-04-15 | Rensselaer Polytech Inst | 8-substituierte 2,6-methano-3-benzazocine und 3- substituierte morphinane als opioidrezeptorbindende agenzien |
| CN100537573C (zh) * | 2002-10-09 | 2009-09-09 | 东丽株式会社 | 尿频或尿失禁的治疗或预防剂以及具有含氮环状取代基的吗啡烷衍生物 |
| JP4118824B2 (ja) | 2004-02-24 | 2008-07-16 | 株式会社日立製作所 | 優先パケットの遅延を最小化するシェーピング装置 |
| JP4118826B2 (ja) | 2004-03-01 | 2008-07-16 | リオン株式会社 | 補聴器用ケースなどの製造方法及びその装置 |
| DE602005011113D1 (de) | 2004-03-30 | 2009-01-02 | Toray Industries | Morphinanderivate als mittel gegen juckreiz |
-
2005
- 2005-11-03 TW TW094138512A patent/TW200621785A/zh not_active IP Right Cessation
- 2005-11-03 AR ARP050104603A patent/AR053098A1/es not_active Application Discontinuation
- 2005-11-03 PE PE2005001291A patent/PE20060723A1/es not_active Application Discontinuation
- 2005-11-04 JP JP2006542444A patent/JP4706636B2/ja not_active Expired - Fee Related
- 2005-11-04 EP EP05799891A patent/EP1820505A4/en not_active Withdrawn
- 2005-11-04 CA CA2586181A patent/CA2586181C/en not_active Expired - Fee Related
- 2005-11-04 US US11/667,136 patent/US8470845B2/en not_active Expired - Fee Related
- 2005-11-04 CN CN200580045038XA patent/CN101090722B/zh not_active Expired - Fee Related
- 2005-11-04 KR KR1020077011752A patent/KR101285645B1/ko not_active Expired - Fee Related
- 2005-11-04 MX MX2007005336A patent/MX2007005336A/es active IP Right Grant
- 2005-11-04 WO PCT/JP2005/020297 patent/WO2006049248A1/ja not_active Ceased
-
2007
- 2007-06-04 NO NO20072832A patent/NO20072832L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070085436A (ko) | 2007-08-27 |
| CN101090722A (zh) | 2007-12-19 |
| WO2006049248A1 (ja) | 2006-05-11 |
| CA2586181A1 (en) | 2006-05-11 |
| JPWO2006049248A1 (ja) | 2008-08-07 |
| EP1820505A1 (en) | 2007-08-22 |
| CA2586181C (en) | 2012-11-27 |
| EP1820505A4 (en) | 2010-01-20 |
| JP4706636B2 (ja) | 2011-06-22 |
| HK1115808A1 (en) | 2008-12-12 |
| US20070299100A1 (en) | 2007-12-27 |
| NO20072832L (no) | 2007-08-01 |
| KR101285645B1 (ko) | 2013-07-12 |
| TWI356826B (enExample) | 2012-01-21 |
| TW200621785A (en) | 2006-07-01 |
| US8470845B2 (en) | 2013-06-25 |
| MX2007005336A (es) | 2007-06-25 |
| CN101090722B (zh) | 2011-12-21 |
| AR053098A1 (es) | 2007-04-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20090816A1 (es) | Derivados de pirrolopirimidinona como agentes ligandos de los receptores p2x3 | |
| PE20110568A1 (es) | Agentes terapeuticos 414 | |
| PE20120355A1 (es) | DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1 | |
| PE20060777A1 (es) | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas | |
| PE20010925A1 (es) | Compuestos inhibidores del neuropeptido y utiles para el tratamiento de la disfuncion sexual femenina | |
| PE20071061A1 (es) | Derivados de carbonilo como inhibidores de peptidil-deformilasa (pdf) | |
| PE20170666A1 (es) | 2-(morfolin-4-il)-1,7-naftiridinas | |
| PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
| CR10167A (es) | "uso de derivados de sulfamida heterociclica benzo-fusionada para el tratamiento de dolor" | |
| PE20110222A1 (es) | Inhibidores de dipeptidilpeptidasa iv | |
| MY144659A (en) | 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors | |
| PE20070367A1 (es) | Compuestos de espiropiperidina como inhibidores de la enzima beta secretasa | |
| PE20080951A1 (es) | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS | |
| PE20141681A1 (es) | Inhibidores de btk | |
| PE20091376A1 (es) | Derivados de fenilamino como moduladores de beta-amiloide | |
| PE20070018A1 (es) | Compuestos heterociclicos como inhibidores de aspartil proteasas | |
| HUP0400365A2 (hu) | 3-Fluor-pirrolidinek, mint cukorbetegség elleni szerek és a vegyületeket tartalmazó gyógyszerkészítmények | |
| PE20070136A1 (es) | COMPUESTOS DERIVADOS DE N-(PIRIDIN-2-IL)-SULFONAMIDA COMO INHIBIDORES DE LA ENZIMA 11-beta-HIDROXIESTEROIDE DESHIDROGENASA HUMANA TIPO 1 | |
| PE20030497A1 (es) | Combinaciones de un inhibidor de pde 5 y otros agentes activos | |
| PE20060186A1 (es) | Antagonistas de cgrp seleccionados, procedimientos para su preparacion asi como su uso como medicamento | |
| IS8058A (is) | Sýklísk súlfónamíð til að hamla gamma seytiasa | |
| PE20081596A1 (es) | Derivados fluorinados de deferiprona | |
| SE0401342D0 (sv) | Therapeutic compounds | |
| AR043259A1 (es) | Metodo para el tratamiento de insuficiencia cardiaca severa y medicamento para ello | |
| AR059501A1 (es) | Uso de derivados de benzo-heteroaril sulfamida para el tratamiento del dolor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |