PE20060723A1 - Derivados de morfina como agentes analgesicos - Google Patents
Derivados de morfina como agentes analgesicosInfo
- Publication number
- PE20060723A1 PE20060723A1 PE2005001291A PE2005001291A PE20060723A1 PE 20060723 A1 PE20060723 A1 PE 20060723A1 PE 2005001291 A PE2005001291 A PE 2005001291A PE 2005001291 A PE2005001291 A PE 2005001291A PE 20060723 A1 PE20060723 A1 PE 20060723A1
- Authority
- PE
- Peru
- Prior art keywords
- alcoxy
- morphinan
- ona
- cyclopropylmethyl
- dihydroxy
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004320583 | 2004-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060723A1 true PE20060723A1 (es) | 2006-08-29 |
Family
ID=36319248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001291A PE20060723A1 (es) | 2004-11-04 | 2005-11-03 | Derivados de morfina como agentes analgesicos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8470845B2 (enExample) |
| EP (1) | EP1820505A4 (enExample) |
| JP (1) | JP4706636B2 (enExample) |
| KR (1) | KR101285645B1 (enExample) |
| CN (1) | CN101090722B (enExample) |
| AR (1) | AR053098A1 (enExample) |
| CA (1) | CA2586181C (enExample) |
| MX (1) | MX2007005336A (enExample) |
| NO (1) | NO20072832L (enExample) |
| PE (1) | PE20060723A1 (enExample) |
| TW (1) | TW200621785A (enExample) |
| WO (1) | WO2006049248A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101356176B (zh) | 2005-11-09 | 2011-12-21 | 东丽株式会社 | 功能性肠病的治疗或预防药 |
| CA2634055C (en) | 2005-12-21 | 2011-07-05 | Toray Industries, Inc. | Antitussive agent |
| FR2902341B1 (fr) | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
| FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
| ES2648037T3 (es) * | 2007-05-21 | 2017-12-28 | Toray Industries, Inc. | Preparación oral que comprende un ácido orgánico específico y método para mejorar la propiedad de disolución y la estabilidad química de la preparación oral |
| KR101510799B1 (ko) * | 2007-05-21 | 2015-04-10 | 도레이 카부시키가이샤 | 의약 정제의 제조법 |
| JP5564943B2 (ja) * | 2007-05-21 | 2014-08-06 | 東レ株式会社 | 結晶性微粉化粒子 |
| FR2930447B1 (fr) | 2008-04-25 | 2010-07-30 | Sod Conseils Rech Applic | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique |
| PT3761982T (pt) | 2018-03-08 | 2024-12-30 | Univ Kansas | Utilização da nalfurafina no tratamento de doenças desmielinizantes |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4118823B1 (enExample) * | 1964-02-03 | 1966-10-31 | ||
| US3318884A (en) * | 1965-07-21 | 1967-05-09 | American Cyanamid Co | Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives |
| NL8102558A (nl) * | 1981-05-25 | 1982-12-16 | Alcoa Nederland Bv | Lichtmast met versterking van de opening in het onderste gedeelte. |
| CA2105072C (en) * | 1992-01-23 | 1998-07-28 | Hiroshi Nagase | Morphinan derivative and its pharmaceutical applications |
| AU686203B2 (en) | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| JP3348230B2 (ja) * | 1995-03-03 | 2002-11-20 | アルゴス ファーマシューティカル コーポレーション | 尿失禁の治療用のデキシトルメトルファン又はデキシトルオルファンの使用 |
| CN1374963A (zh) * | 1999-07-19 | 2002-10-16 | 东丽株式会社 | 尿频或尿失禁的治疗或预防剂 |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| DE60109960T2 (de) | 2000-10-31 | 2006-02-16 | Rensselaer Polytechnic Institute | 8-substituierte 2,6-methano-3-benzazocine und 3-substituierte morphinane als opioidrezeptorbindende agenzien |
| CA2501389C (en) | 2002-10-09 | 2013-01-08 | Toray Industries, Inc. | Remedies or preventives for frequent urination or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group |
| JP4118824B2 (ja) | 2004-02-24 | 2008-07-16 | 株式会社日立製作所 | 優先パケットの遅延を最小化するシェーピング装置 |
| JP4118826B2 (ja) | 2004-03-01 | 2008-07-16 | リオン株式会社 | 補聴器用ケースなどの製造方法及びその装置 |
| ATE414516T1 (de) | 2004-03-30 | 2008-12-15 | Toray Industries | Morphinanderivate als mittel gegen juckreiz |
-
2005
- 2005-11-03 TW TW094138512A patent/TW200621785A/zh not_active IP Right Cessation
- 2005-11-03 PE PE2005001291A patent/PE20060723A1/es not_active Application Discontinuation
- 2005-11-03 AR ARP050104603A patent/AR053098A1/es not_active Application Discontinuation
- 2005-11-04 MX MX2007005336A patent/MX2007005336A/es active IP Right Grant
- 2005-11-04 CN CN200580045038XA patent/CN101090722B/zh not_active Expired - Fee Related
- 2005-11-04 WO PCT/JP2005/020297 patent/WO2006049248A1/ja not_active Ceased
- 2005-11-04 US US11/667,136 patent/US8470845B2/en not_active Expired - Fee Related
- 2005-11-04 JP JP2006542444A patent/JP4706636B2/ja not_active Expired - Fee Related
- 2005-11-04 CA CA2586181A patent/CA2586181C/en not_active Expired - Fee Related
- 2005-11-04 EP EP05799891A patent/EP1820505A4/en not_active Withdrawn
- 2005-11-04 KR KR1020077011752A patent/KR101285645B1/ko not_active Expired - Fee Related
-
2007
- 2007-06-04 NO NO20072832A patent/NO20072832L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2586181A1 (en) | 2006-05-11 |
| CN101090722B (zh) | 2011-12-21 |
| TWI356826B (enExample) | 2012-01-21 |
| TW200621785A (en) | 2006-07-01 |
| EP1820505A4 (en) | 2010-01-20 |
| US8470845B2 (en) | 2013-06-25 |
| NO20072832L (no) | 2007-08-01 |
| MX2007005336A (es) | 2007-06-25 |
| CA2586181C (en) | 2012-11-27 |
| AR053098A1 (es) | 2007-04-25 |
| WO2006049248A1 (ja) | 2006-05-11 |
| US20070299100A1 (en) | 2007-12-27 |
| KR20070085436A (ko) | 2007-08-27 |
| CN101090722A (zh) | 2007-12-19 |
| JP4706636B2 (ja) | 2011-06-22 |
| KR101285645B1 (ko) | 2013-07-12 |
| HK1115808A1 (en) | 2008-12-12 |
| JPWO2006049248A1 (ja) | 2008-08-07 |
| EP1820505A1 (en) | 2007-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |