AR053098A1 - Analgesico derivado de morfinano - Google Patents
Analgesico derivado de morfinanoInfo
- Publication number
- AR053098A1 AR053098A1 ARP050104603A ARP050104603A AR053098A1 AR 053098 A1 AR053098 A1 AR 053098A1 AR P050104603 A ARP050104603 A AR P050104603A AR P050104603 A ARP050104603 A AR P050104603A AR 053098 A1 AR053098 A1 AR 053098A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- atoms
- atom
- nr8r9
- represent
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000004429 atom Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 abstract 2
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003968 arylidene group Chemical group [H]C(c)=* 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- BWOVZCWSJFYBRM-UHFFFAOYSA-N carbononitridic isocyanate Chemical compound O=C=NC#N BWOVZCWSJFYBRM-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- ZXIJMRYMVAMXQP-UHFFFAOYSA-N cycloheptene Chemical compound C1CCC=CCC1 ZXIJMRYMVAMXQP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 150000002540 isothiocyanates Chemical class 0.000 abstract 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 150000003457 sulfones Chemical class 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004320583 | 2004-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053098A1 true AR053098A1 (es) | 2007-04-25 |
Family
ID=36319248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104603A AR053098A1 (es) | 2004-11-04 | 2005-11-03 | Analgesico derivado de morfinano |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8470845B2 (enExample) |
| EP (1) | EP1820505A4 (enExample) |
| JP (1) | JP4706636B2 (enExample) |
| KR (1) | KR101285645B1 (enExample) |
| CN (1) | CN101090722B (enExample) |
| AR (1) | AR053098A1 (enExample) |
| CA (1) | CA2586181C (enExample) |
| MX (1) | MX2007005336A (enExample) |
| NO (1) | NO20072832L (enExample) |
| PE (1) | PE20060723A1 (enExample) |
| TW (1) | TW200621785A (enExample) |
| WO (1) | WO2006049248A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007055184A1 (ja) * | 2005-11-09 | 2007-05-18 | Toray Industries, Inc. | 機能性腸障害の治療または予防剤 |
| WO2007072749A1 (ja) * | 2005-12-21 | 2007-06-28 | Toray Industries, Inc. | 鎮咳剤 |
| FR2902341B1 (fr) | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
| FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
| AU2008254038B2 (en) * | 2007-05-21 | 2013-01-10 | Toray Industries, Inc. | Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation |
| ES2627217T3 (es) * | 2007-05-21 | 2017-07-27 | Toray Industries, Inc. | Partículas micropulverizadas cristalinas |
| AU2008254039B2 (en) * | 2007-05-21 | 2013-10-24 | Toray Industries, Inc. | Method for producing pharmaceutical tablet |
| FR2930447B1 (fr) | 2008-04-25 | 2010-07-30 | Sod Conseils Rech Applic | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique |
| DK3761982T3 (da) | 2018-03-08 | 2025-01-02 | Victoria Link Ltd | Anvendelse af nalfurafin til behandling af demyeliniserende sygdomme |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4118823B1 (enExample) * | 1964-02-03 | 1966-10-31 | ||
| US3318884A (en) * | 1965-07-21 | 1967-05-09 | American Cyanamid Co | Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives |
| NL8102558A (nl) * | 1981-05-25 | 1982-12-16 | Alcoa Nederland Bv | Lichtmast met versterking van de opening in het onderste gedeelte. |
| ES2121988T3 (es) * | 1992-01-23 | 1998-12-16 | Toray Industries | Derivado de morfinano y uso medicinal. |
| NZ268969A (en) * | 1993-07-23 | 1997-06-24 | Toray Industries | Morphinan derivatives and pharmaceutical compositions |
| AU5090796A (en) * | 1995-03-03 | 1996-09-23 | Algos Pharmaceutical Corporation | Use of dextromethorphan or dextrorphan for the treatment of urinary incontinence |
| AU6020300A (en) * | 1999-07-19 | 2001-02-05 | Toray Industries, Inc. | Remedies or preventives for frequent urination or urinary incontinence |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| JP4340437B2 (ja) | 2000-10-31 | 2009-10-07 | レンセラール ポリテクニック インスティチュート | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
| BR0314754A (pt) * | 2002-10-09 | 2005-07-26 | Toray Industries | Agente terapêutico ou profilático para a frequência urinária ou a incontinência urinária ou um seu sal de adição de ácido farmaceuticamente aceitável, método para terapia ou profilaxia para frequência urinária, urgência urinária ou incontinência urinária, uso de um derivado de morfina tendo um grupo heterocìclico contendo nitrogênio ou de um seu sal de adição de ácido farmaceuticamente aceitável, derivado de morfina ou um seu sal de adição de ácido farmaceuticamente aceitável, produto farmacêutico, e, composição farmacêutica |
| JP4118824B2 (ja) | 2004-02-24 | 2008-07-16 | 株式会社日立製作所 | 優先パケットの遅延を最小化するシェーピング装置 |
| JP4118826B2 (ja) | 2004-03-01 | 2008-07-16 | リオン株式会社 | 補聴器用ケースなどの製造方法及びその装置 |
| TW200533355A (en) | 2004-03-30 | 2005-10-16 | Toray Industries | Antipruritic agent |
-
2005
- 2005-11-03 PE PE2005001291A patent/PE20060723A1/es not_active Application Discontinuation
- 2005-11-03 AR ARP050104603A patent/AR053098A1/es not_active Application Discontinuation
- 2005-11-03 TW TW094138512A patent/TW200621785A/zh not_active IP Right Cessation
- 2005-11-04 US US11/667,136 patent/US8470845B2/en not_active Expired - Fee Related
- 2005-11-04 EP EP05799891A patent/EP1820505A4/en not_active Withdrawn
- 2005-11-04 CN CN200580045038XA patent/CN101090722B/zh not_active Expired - Fee Related
- 2005-11-04 CA CA2586181A patent/CA2586181C/en not_active Expired - Fee Related
- 2005-11-04 WO PCT/JP2005/020297 patent/WO2006049248A1/ja not_active Ceased
- 2005-11-04 KR KR1020077011752A patent/KR101285645B1/ko not_active Expired - Fee Related
- 2005-11-04 MX MX2007005336A patent/MX2007005336A/es active IP Right Grant
- 2005-11-04 JP JP2006542444A patent/JP4706636B2/ja not_active Expired - Fee Related
-
2007
- 2007-06-04 NO NO20072832A patent/NO20072832L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1115808A1 (en) | 2008-12-12 |
| CA2586181C (en) | 2012-11-27 |
| US20070299100A1 (en) | 2007-12-27 |
| KR20070085436A (ko) | 2007-08-27 |
| CA2586181A1 (en) | 2006-05-11 |
| TW200621785A (en) | 2006-07-01 |
| WO2006049248A1 (ja) | 2006-05-11 |
| TWI356826B (enExample) | 2012-01-21 |
| US8470845B2 (en) | 2013-06-25 |
| PE20060723A1 (es) | 2006-08-29 |
| CN101090722B (zh) | 2011-12-21 |
| MX2007005336A (es) | 2007-06-25 |
| CN101090722A (zh) | 2007-12-19 |
| NO20072832L (no) | 2007-08-01 |
| EP1820505A1 (en) | 2007-08-22 |
| JP4706636B2 (ja) | 2011-06-22 |
| KR101285645B1 (ko) | 2013-07-12 |
| EP1820505A4 (en) | 2010-01-20 |
| JPWO2006049248A1 (ja) | 2008-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR091790A1 (es) | Derivados de isoquinolin-1-ona y sus usos | |
| CO6251241A2 (es) | Compuestos de prolina modificados con actividad anti-vhc | |
| AR053098A1 (es) | Analgesico derivado de morfinano | |
| AR030324A1 (es) | Derivados de 4-fenil-piridina | |
| AR031528A1 (es) | Compuestos de pirazolopirimidina y su uso para preparar una composicion farmaceutica | |
| AR038863A1 (es) | Uso de un inhibidor de garft y/o de aicarft y de un agente antitoxico para preparar un medicamento para destruir selectivamente celulas mtap-deficientes de un mamifero | |
| AR075249A1 (es) | Derivados de 6-(6-o-sustituido-triazolopiridazina-sulfanil) benzotiazoles y bencimidazoles, metodo de preparacion de los mismos e intermediarios de dicha sintesis, medicamentos que los contienen y uso de los mismos en el tratamiento del cancer, artritis, alergias y otras enfermedades. | |
| AR062677A1 (es) | Derivados de biaril-sulfonamida, procesos de produccion y composiciones farmaceuticas que los comprenden | |
| AR077267A1 (es) | Derivados nitrogenados heterociclicos inhibidores selectivos de pi3k, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y/o autoinmunes. | |
| EA200600527A1 (ru) | Активирующее ppar соединение и содержащая его фармацевтическая композиция | |
| AR063331A1 (es) | Derivados de biaril eter urea y composiciones farmaceuticas | |
| AR088218A1 (es) | Compuestos heterociclicos utiles como inhibidores de pi3k | |
| AR045651A1 (es) | Derivados de tiazol como moduladores del receptor de cannabinoide | |
| CR20200540A (es) | DERIVADOS DE AMINA PARA EL CONTROL DE PLAGAS (Divisional 2019-0244) | |
| AR077328A1 (es) | Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos | |
| AR050434A1 (es) | Derivados de ciclohexano como inhibidores de cotransportador de na+ - glucosa; composiciones farmaceuticas que los contienen como principio activo y el uso de los mismos en el tratamiento de la diabates tipo i y ii y de la obesidad | |
| AR086156A1 (es) | Compuesto de amida y su uso medicinal | |
| AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| AR089175A1 (es) | Inhibidores de pak para el tratamiento de trastornos de proliferacion celular | |
| AR082889A1 (es) | Compuestos y composiciones para la inhibicion de nampt | |
| AR084905A1 (es) | Derivados de 2,3-dihidro-furo[2,3-c]piridina, composiciones farmaceuticas que los comprenden y su uso en el tratamiento de enfermedades mediadas por la activacion del receptor gpr119 acoplado a proteinas g | |
| ECSP067053A (es) | 1-aza-biciclo[3.3.1]nonanos | |
| AR062079A1 (es) | Derivados de azaindol sustituidos, procedimientos para su preparacion, composiciones farmaceuticas que contienen estos compuestos y el uso de derivados de azaindol sustituidos para la preparacion de composiciones farmaceuticas | |
| AR066604A1 (es) | Derivados de arilamida pirimidona, medicamentos que los contienen y usos terapeuticos para prevenir y/o tratar enfermedades neurodegenerativas fundamentalmente. | |
| ECSP11011196A (es) | Derivados de piperidina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |