CN101090722B - 镇痛剂 - Google Patents

镇痛剂 Download PDF

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Publication number
CN101090722B
CN101090722B CN200580045038XA CN200580045038A CN101090722B CN 101090722 B CN101090722 B CN 101090722B CN 200580045038X A CN200580045038X A CN 200580045038XA CN 200580045038 A CN200580045038 A CN 200580045038A CN 101090722 B CN101090722 B CN 101090722B
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CN
China
Prior art keywords
allyl
cpm
carbon atoms
pain
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200580045038XA
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English (en)
Chinese (zh)
Other versions
CN101090722A (zh
Inventor
泉本直树
川村邦昭
驹形俊和
桥本忠俊
长袋洋
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Toray Industries Inc
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Toray Industries Inc
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Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of CN101090722A publication Critical patent/CN101090722A/zh
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Publication of CN101090722B publication Critical patent/CN101090722B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200580045038XA 2004-11-04 2005-11-04 镇痛剂 Expired - Fee Related CN101090722B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP320583/2004 2004-11-04
JP2004320583 2004-11-04
PCT/JP2005/020297 WO2006049248A1 (ja) 2004-11-04 2005-11-04 鎮痛剤

Publications (2)

Publication Number Publication Date
CN101090722A CN101090722A (zh) 2007-12-19
CN101090722B true CN101090722B (zh) 2011-12-21

Family

ID=36319248

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200580045038XA Expired - Fee Related CN101090722B (zh) 2004-11-04 2005-11-04 镇痛剂

Country Status (12)

Country Link
US (1) US8470845B2 (enExample)
EP (1) EP1820505A4 (enExample)
JP (1) JP4706636B2 (enExample)
KR (1) KR101285645B1 (enExample)
CN (1) CN101090722B (enExample)
AR (1) AR053098A1 (enExample)
CA (1) CA2586181C (enExample)
MX (1) MX2007005336A (enExample)
NO (1) NO20072832L (enExample)
PE (1) PE20060723A1 (enExample)
TW (1) TW200621785A (enExample)
WO (1) WO2006049248A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806294A (en) * 2005-11-09 2008-02-01 Toray Industries Therapeutic or prophylactic agent for functional intestinal injury
CA2634055C (en) 2005-12-21 2011-07-05 Toray Industries, Inc. Antitussive agent
FR2902341B1 (fr) 2006-06-16 2011-02-25 Scras Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2910327B1 (fr) 2006-12-22 2013-04-26 Scras Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
CA2687956C (en) * 2007-05-21 2015-03-31 Toray Industries, Inc. Method for producing pharmaceutical tablet
WO2008143240A1 (ja) * 2007-05-21 2008-11-27 Toray Industries, Inc. 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法
JP5564943B2 (ja) * 2007-05-21 2014-08-06 東レ株式会社 結晶性微粉化粒子
FR2930447B1 (fr) 2008-04-25 2010-07-30 Sod Conseils Rech Applic Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique
CA3091752A1 (en) 2018-03-08 2019-09-12 Victoria Link Ltd Treatment of demyelinating diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033457A1 (ja) * 2002-10-09 2004-04-22 Toray Industries, Inc. 頻尿もしくは尿失禁の治療または予防剤および含窒素環状置換基を有するモルヒナン誘導体
JP2004522706A (ja) * 2000-10-31 2004-07-29 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4118823B1 (enExample) * 1964-02-03 1966-10-31
US3318886A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 7-hydroxymethyl-7, 8-dihydro-6-amino-6, 14-endoethenocodides and morphide
NL8102558A (nl) * 1981-05-25 1982-12-16 Alcoa Nederland Bv Lichtmast met versterking van de opening in het onderste gedeelte.
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
NZ268969A (en) 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
JP3348230B2 (ja) 1995-03-03 2002-11-20 アルゴス ファーマシューティカル コーポレーション 尿失禁の治療用のデキシトルメトルファン又はデキシトルオルファンの使用
AU6020300A (en) 1999-07-19 2001-02-05 Toray Industries, Inc. Remedies or preventives for frequent urination or urinary incontinence
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
JP4118824B2 (ja) 2004-02-24 2008-07-16 株式会社日立製作所 優先パケットの遅延を最小化するシェーピング装置
JP4118826B2 (ja) 2004-03-01 2008-07-16 リオン株式会社 補聴器用ケースなどの製造方法及びその装置
DE602005011113D1 (de) 2004-03-30 2009-01-02 Toray Industries Morphinanderivate als mittel gegen juckreiz

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004522706A (ja) * 2000-10-31 2004-07-29 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
WO2004033457A1 (ja) * 2002-10-09 2004-04-22 Toray Industries, Inc. 頻尿もしくは尿失禁の治療または予防剤および含窒素環状置換基を有するモルヒナン誘導体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Sayre L. M. et al.，.Design and synthesis of Naltrexone-Derived affinitylabelswithnonequilibrium opioid agonist andantagonistactivities.Evidence for the existence of differentμreceptorsubtypes indifferent tissues.Journal of Medicinal Chemistry,第27卷， 第10期.1984,第27卷，(第10期),1325-1335.
Sayre L. M. et al.,.Design and synthesis of Naltrexone-Derived affinitylabelswithnonequilibrium opioid agonist andantagonistactivities.Evidence for the existence of differentμreceptorsubtypes indifferent tissues.Journal of Medicinal Chemistry,第27卷, 第10期.1984,第27卷,(第10期),1325-1335. *

Also Published As

Publication number Publication date
KR20070085436A (ko) 2007-08-27
CN101090722A (zh) 2007-12-19
WO2006049248A1 (ja) 2006-05-11
CA2586181A1 (en) 2006-05-11
JPWO2006049248A1 (ja) 2008-08-07
EP1820505A1 (en) 2007-08-22
CA2586181C (en) 2012-11-27
EP1820505A4 (en) 2010-01-20
JP4706636B2 (ja) 2011-06-22
PE20060723A1 (es) 2006-08-29
HK1115808A1 (en) 2008-12-12
US20070299100A1 (en) 2007-12-27
NO20072832L (no) 2007-08-01
KR101285645B1 (ko) 2013-07-12
TWI356826B (enExample) 2012-01-21
TW200621785A (en) 2006-07-01
US8470845B2 (en) 2013-06-25
MX2007005336A (es) 2007-06-25
AR053098A1 (es) 2007-04-25

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