PE20051045A1 - Procesos para la preparacion de pirazolo [1,5-alfa]-1,3,5-triazinas e intermedios de las mismas - Google Patents
Procesos para la preparacion de pirazolo [1,5-alfa]-1,3,5-triazinas e intermedios de las mismasInfo
- Publication number
- PE20051045A1 PE20051045A1 PE2004001150A PE2004001150A PE20051045A1 PE 20051045 A1 PE20051045 A1 PE 20051045A1 PE 2004001150 A PE2004001150 A PE 2004001150A PE 2004001150 A PE2004001150 A PE 2004001150A PE 20051045 A1 PE20051045 A1 PE 20051045A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- compound
- alkyl
- pirazolo
- triazines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA I, DONDE AR ES FENILO, PIRIDILO SUSTITUIDO CON 0-5 R3; R1 Y R2 SON CADA UNO H, ALQUILO C1-C8, ALCOXIALQUILO C1-C6; R3 ES H, HALO, CN, NITRO, ALQUILO C1-C4, ENTRE OTROS; RA Y RB SON CADA UNO ALQUILO C1-C4, QUE COMPRENDE: A) PONER EN CONTACTO EL COMPUESTO III CON PX3 EN PRESENCIA DE UNA AMINA SELECCIONADA DE TRIFENILAMINA, DIETILAMINA, TRIBENCILAMINA, ENTRE OTROS, PARA PROPORCIONAR EL COMPUESTO II, DONDE X ES HALO; B) PONER EN CONTACTO EL COMPUESTO II CON NHR1R2 PARA PROPORCIONAR EL COMPUESTO I. SON COMPUESTOS PREFERIDOS: BENCENOSULFONATO DE N,N-BIS(2-METOXIETIL)-8-(4-METOXI-2-METILFENIL)-2,7-DIMETILPIRAZOLO[1,5-A][1,3,5]TRIAZIN-4-AMINA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE LIBERACION DE CORTICOTROPINA (CRF) UTILES EN EL TRATAMIENTO DE ANSIEDAD Y DEPRESION
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52505003P | 2003-11-25 | 2003-11-25 | |
US10/985,236 US7208596B2 (en) | 2003-11-25 | 2004-11-10 | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20051045A1 true PE20051045A1 (es) | 2005-12-29 |
Family
ID=34636532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004001150A PE20051045A1 (es) | 2003-11-25 | 2004-11-24 | Procesos para la preparacion de pirazolo [1,5-alfa]-1,3,5-triazinas e intermedios de las mismas |
Country Status (15)
Country | Link |
---|---|
US (2) | US7208596B2 (es) |
EP (1) | EP1706408A2 (es) |
JP (1) | JP2007512360A (es) |
KR (1) | KR20060116208A (es) |
AR (1) | AR046851A1 (es) |
AU (1) | AU2004293435A1 (es) |
BR (1) | BRPI0416821A (es) |
CA (1) | CA2546652A1 (es) |
IL (1) | IL175753A0 (es) |
MX (1) | MXPA06005482A (es) |
NO (1) | NO20062943L (es) |
PE (1) | PE20051045A1 (es) |
RU (1) | RU2006121075A (es) |
TW (1) | TW200529827A (es) |
WO (1) | WO2005051954A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7208596B2 (en) * | 2003-11-25 | 2007-04-24 | Bristol-Myers Squibb Pharma Company | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
EP2530078A1 (en) | 2010-01-27 | 2012-12-05 | Takeda Pharmaceutical Company Limited | Thiazole derivative |
EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
AR086554A1 (es) | 2011-05-27 | 2014-01-08 | Novartis Ag | Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina |
CA2867043A1 (en) | 2012-05-03 | 2013-11-07 | Novartis Ag | L-malate salt of 2,7-diaza-spiro[4.5]dec-7-yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3910907A (en) * | 1973-07-09 | 1975-10-07 | Icn Pharmaceuticals | Pyrazolo(1,5-a)-1,3,5-triazines |
US4824834A (en) | 1986-10-31 | 1989-04-25 | Otsuka Pharmaceutical Company, Limited | Pyrazolotriazine compounds |
DE3722072A1 (de) * | 1987-07-01 | 1989-01-12 | Schering Ag | 6,7-dihydro-pyrazolo(1,5-a)(1,3,5) triazin-2-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider und pflanzenwuchsregulierender wirkung |
JP2691317B2 (ja) * | 1989-08-25 | 1997-12-17 | 株式会社大塚製薬工場 | 4―ヒドロキシ―8―(3―低級アルコキシ―4―フェニルスルフィニルフェニル)ピラゾロ〔1,5―a〕―1,3,5―トリアジン光学活性体の塩類及びその製造方法 |
US5484760A (en) * | 1990-12-31 | 1996-01-16 | Monsanto Company | Herbicide antidotes as safeners for reducing phytotoxicity resulting from synergistic interaction between herbicides and other pesticides |
AU667575B2 (en) | 1992-10-20 | 1996-03-28 | Otsuka Pharmaceutical Co., Ltd. | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor |
CN1088574A (zh) | 1992-12-24 | 1994-06-29 | 中国科学院化学研究所 | 2,6-二甲基-4-叔丁基-3-硝基-苯乙氰的合成方法 |
US6313124B1 (en) * | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
US6191131B1 (en) * | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
DE69738197T2 (de) | 1996-07-24 | 2008-07-17 | Bristol-Myers Squibb Pharma Co. | Azolotriazine und pyrimidine |
DE69736711T2 (de) | 1996-08-28 | 2007-09-20 | Pfizer Inc. | Substituierte 6,5-heterobicyclische-derivate |
ATE228508T1 (de) * | 1998-12-21 | 2002-12-15 | Lonza Ag | Verfahren zur herstellung von n-(amino-4,6- dihalogenpyrimidin)-formamiden |
AU7737900A (en) | 1999-09-30 | 2001-04-30 | Neurogen Corporation | Amino substituted pyrazolo(1,5,-a)-1,5-pyrimidines and pyrazolo(1,5-a)-1,3,5-triazines |
JP2001302658A (ja) | 2000-04-18 | 2001-10-31 | Showa Denko Kk | 3−イソクロマノン類の製造方法 |
WO2002072202A1 (en) * | 2001-03-13 | 2002-09-19 | Bristol-Myers Squibb Pharma Company | 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands |
US7208596B2 (en) * | 2003-11-25 | 2007-04-24 | Bristol-Myers Squibb Pharma Company | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
-
2004
- 2004-11-10 US US10/985,236 patent/US7208596B2/en active Active
- 2004-11-19 BR BRPI0416821-6A patent/BRPI0416821A/pt not_active IP Right Cessation
- 2004-11-19 KR KR1020067009566A patent/KR20060116208A/ko not_active Application Discontinuation
- 2004-11-19 RU RU2006121075/04A patent/RU2006121075A/ru not_active Application Discontinuation
- 2004-11-19 CA CA002546652A patent/CA2546652A1/en not_active Abandoned
- 2004-11-19 EP EP04811716A patent/EP1706408A2/en not_active Withdrawn
- 2004-11-19 JP JP2006541577A patent/JP2007512360A/ja active Pending
- 2004-11-19 MX MXPA06005482A patent/MXPA06005482A/es unknown
- 2004-11-19 WO PCT/US2004/039046 patent/WO2005051954A2/en active Application Filing
- 2004-11-19 AU AU2004293435A patent/AU2004293435A1/en not_active Abandoned
- 2004-11-24 TW TW093136179A patent/TW200529827A/zh unknown
- 2004-11-24 PE PE2004001150A patent/PE20051045A1/es not_active Application Discontinuation
- 2004-11-24 AR ARP040104336A patent/AR046851A1/es unknown
-
2006
- 2006-05-18 IL IL175753A patent/IL175753A0/en unknown
- 2006-06-23 NO NO20062943A patent/NO20062943L/no not_active Application Discontinuation
-
2007
- 2007-03-13 US US11/717,440 patent/US7442792B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20050143380A1 (en) | 2005-06-30 |
MXPA06005482A (es) | 2006-08-11 |
EP1706408A2 (en) | 2006-10-04 |
WO2005051954A3 (en) | 2005-11-17 |
WO2005051954A2 (en) | 2005-06-09 |
IL175753A0 (en) | 2006-09-05 |
AR046851A1 (es) | 2005-12-28 |
CA2546652A1 (en) | 2005-06-09 |
JP2007512360A (ja) | 2007-05-17 |
AU2004293435A1 (en) | 2005-06-09 |
KR20060116208A (ko) | 2006-11-14 |
US20070161790A1 (en) | 2007-07-12 |
US7442792B2 (en) | 2008-10-28 |
NO20062943L (no) | 2006-08-25 |
RU2006121075A (ru) | 2008-01-10 |
TW200529827A (en) | 2005-09-16 |
BRPI0416821A (pt) | 2007-03-06 |
US7208596B2 (en) | 2007-04-24 |
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Legal Events
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FC | Refusal |