PE20050995A1 - Derivados oxazol de tetraciclinas - Google Patents

Derivados oxazol de tetraciclinas

Info

Publication number
PE20050995A1
PE20050995A1 PE2004001203A PE2004001203A PE20050995A1 PE 20050995 A1 PE20050995 A1 PE 20050995A1 PE 2004001203 A PE2004001203 A PE 2004001203A PE 2004001203 A PE2004001203 A PE 2004001203A PE 20050995 A1 PE20050995 A1 PE 20050995A1
Authority
PE
Peru
Prior art keywords
trihydroxy
dioxo
dimethylamine
carboxamide
octahydrotetracene
Prior art date
Application number
PE2004001203A
Other languages
English (en)
Inventor
Phaik-Eng Sum
David Brian How
Darrin William Hopper
Matthew Douglas Vera
Joshua James Sabatini
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34681543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050995(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20050995A1 publication Critical patent/PE20050995A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE X ES H, AMINO, VINILO, OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS; A" ES A, B, DONDE R ES ALQUILO, ALQUENILO, ALQUINILO OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS; Y ES H, ALQUILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (6AR,7AS,8S,11AS)-5,8-BIS(DIMETILAMINO)-2-(2,2-DIFENILVINIL)-9,11A,12-TRIHIDROXI-11,13-DIOXO-6,6A,7,7A,8,11,11A,13-OCTAHIDROTETRACENO[2,1-D][1,3]OXAZOL-10-CARBOXAMIDA; (7AS,8S,11AS)-8-(DIMETILAMINO)-9,11A,13-TRIHIDROXI-2-(2-METIL-1-PROPENIL)-11,12-DIOXO-7,7A,8,11,11A,12-HEXAHIDRONAFTACENOL[2,1-D][1,3]OXAZOL-10-CARBOXAMIDA; (6AR,7AS,8S,11AS)-2-TER-BUTIL-5,8-BIS(DIMETILAMINO)-9,11A,12-TRIHIDROXI-11,13-DIOXO-6,6A,7,7A,8,11,11A,13-OCTAHIDROTETRACENO[2,1-D][1,3]OXAZOL-10-CARBOXAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO DE PREPARACION. DICHOS COMPUESTOS EXHIBEN ACTIVIDAD ANTIBACTERIANA CONTRA UN AMPLIO ESPECTRO DE ORGANISMOS LOS CUALES SON RESISTENTES A TETRACICLINAS Y OTROS ANTIBIOTICOS
PE2004001203A 2003-12-08 2004-12-07 Derivados oxazol de tetraciclinas PE20050995A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52792803P 2003-12-08 2003-12-08
US58482304P 2004-07-01 2004-07-01

Publications (1)

Publication Number Publication Date
PE20050995A1 true PE20050995A1 (es) 2006-01-11

Family

ID=34681543

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004001203A PE20050995A1 (es) 2003-12-08 2004-12-07 Derivados oxazol de tetraciclinas

Country Status (25)

Country Link
US (3) US7176225B2 (es)
EP (2) EP2157085B1 (es)
JP (1) JP4848287B2 (es)
KR (1) KR101164262B1 (es)
CN (1) CN100545151C (es)
AR (1) AR047274A1 (es)
AT (2) ATE444290T1 (es)
AU (1) AU2004297243B2 (es)
BR (1) BRPI0417421A (es)
CA (1) CA2546895A1 (es)
CO (1) CO5700818A2 (es)
CR (1) CR8437A (es)
DE (1) DE602004023417D1 (es)
EC (1) ECSP066605A (es)
ES (2) ES2372635T3 (es)
IL (2) IL176162A (es)
MY (1) MY146098A (es)
NO (1) NO20062629L (es)
PA (1) PA8619601A1 (es)
PE (1) PE20050995A1 (es)
RU (1) RU2415844C2 (es)
SG (1) SG148216A1 (es)
TW (1) TW200528437A (es)
UA (2) UA83266C2 (es)
WO (1) WO2005056538A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2607453T3 (es) 2004-05-21 2017-03-31 President And Fellows Of Harvard College Síntesis de tetraciclinas y sus análogos
AU2005299294B2 (en) 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
WO2007014154A2 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
EP2016044B1 (en) 2006-04-07 2020-06-10 President and Fellows of Harvard College Pentacycline derivatives for the treatment of infections
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP3056487B1 (en) 2006-10-11 2018-02-21 President and Fellows of Harvard College Synthesis of enone intermediate
US8121767B2 (en) * 2007-11-02 2012-02-21 GM Global Technology Operations LLC Predicted and immediate output torque control architecture for a hybrid powertrain system
CN101861300B (zh) * 2007-11-14 2014-07-09 桑多斯股份公司 盐酸替吉环素的晶型
JP2011527708A (ja) 2008-07-11 2011-11-04 ニュメディックス 減少した抗菌活性および神経保護作用の利点を有するテトラサイクリン誘導体
WO2010070093A1 (en) 2008-12-18 2010-06-24 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26253A (en) * 1859-11-29 Vegetable-cutter
US2482055A (en) 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US3007965A (en) 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (es) 1960-05-23 1966-05-25
US3338963A (en) 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3360557A (en) 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3341585A (en) 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3360561A (en) 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US4806529A (en) 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
ES2168254T3 (es) * 1991-10-04 2002-06-16 American Cyanamid Co Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
MXPA02001471A (es) * 1999-08-10 2002-07-02 Smithkline Beecham Corp 4,4-diaril ciclohexanos 1,4-substituidos.
EP2332546A1 (en) * 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of stroke

Also Published As

Publication number Publication date
US20080064667A1 (en) 2008-03-13
RU2006118367A (ru) 2008-01-20
KR20060105047A (ko) 2006-10-09
ECSP066605A (es) 2006-10-25
ES2331574T3 (es) 2010-01-08
JP2007515411A (ja) 2007-06-14
WO2005056538A1 (en) 2005-06-23
CO5700818A2 (es) 2006-11-30
IL206050A (en) 2013-01-31
NO20062629L (no) 2006-09-06
EP2157085B1 (en) 2011-09-21
BRPI0417421A (pt) 2007-03-13
AU2004297243B2 (en) 2011-02-17
US7365087B2 (en) 2008-04-29
IL176162A0 (en) 2006-10-05
CN100545151C (zh) 2009-09-30
AU2004297243A1 (en) 2005-06-23
US20050153944A1 (en) 2005-07-14
CN1890226A (zh) 2007-01-03
ES2372635T3 (es) 2012-01-25
US20080177080A1 (en) 2008-07-24
AR047274A1 (es) 2006-01-11
CR8437A (es) 2006-10-06
KR101164262B1 (ko) 2012-07-09
EP1692117B1 (en) 2009-09-30
RU2415844C2 (ru) 2011-04-10
UA83268C2 (en) 2008-06-25
MY146098A (en) 2012-06-29
UA83266C2 (en) 2008-06-25
ATE525365T1 (de) 2011-10-15
TW200528437A (en) 2005-09-01
DE602004023417D1 (de) 2009-11-12
IL206050A0 (en) 2010-11-30
ATE444290T1 (de) 2009-10-15
SG148216A1 (en) 2008-12-31
EP1692117A1 (en) 2006-08-23
US7176225B2 (en) 2007-02-13
PA8619601A1 (es) 2006-03-24
JP4848287B2 (ja) 2011-12-28
CA2546895A1 (en) 2005-06-23
IL176162A (en) 2011-09-27
EP2157085A1 (en) 2010-02-24

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