PE20050670A1 - Agentes antimigrana heterociclicos - Google Patents
Agentes antimigrana heterociclicosInfo
- Publication number
- PE20050670A1 PE20050670A1 PE2004001195A PE2004001195A PE20050670A1 PE 20050670 A1 PE20050670 A1 PE 20050670A1 PE 2004001195 A PE2004001195 A PE 2004001195A PE 2004001195 A PE2004001195 A PE 2004001195A PE 20050670 A1 PE20050670 A1 PE 20050670A1
- Authority
- PE
- Peru
- Prior art keywords
- alkylene
- antimigran
- heterocyclic
- agents
- indazol
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical class C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 abstract 1
- 206010047141 Vasodilatation Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000001272 neurogenic effect Effects 0.000 abstract 1
- 230000024883 vasodilation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I DONDE V ES TIAZOLILO, OXADIAZOLILO, TETRAZOLILO, ENTRE OTROS; t ES 0-1; V' ES FENILO, ADAMANTILO, QUINUCLIDILO, ENTRE OTROS; U ES CH2, O, NH; Q ES ALQUILENO(C1-C3)-FLUORENILO, ALQUILENO(C1-C3)-FENILO, ALQUILENO(C1-C3)-NAFTILO, ENTRE OTROS; D ES O, NCN, NSO2ALQUILO(C1-C3); A ES C, N, CH; m Y n SON CADA UNO 0-2; E ES N, CH, C; p 0-1; G, J Y A PUEDEN FORMAR JUNTOS UNA DIHIDROQUINAZOLINA OPCIONALMENTE HALOGENADA. SON COMPUESTOS PREFERIDOS: [1-(3-BENCIL-[1,2,4]OXADIAZOL-5-IL)-2-(7-METIL-1H-INDAZOL-5-IL)-ETIL]-AMIDA DE ACIDO (+/-)-4-(2-OXO-1,4-DIHIDRO-2H-QUINAZOLIN-3-IL-PIPERIDIN-1-CARBOXILICO, 4-(2-OXO-1,2-DIHIDROQUINOLIN-3-IL)PIPERIDIN-1-CARBOXILATO DE (R)-1-(3-(ETOXICARBONIL)-1,2,4-OXADIAZOL-5-IL)-2-(7-METIL-1H-INDAZOL-5-IL)ETILO, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE VASODILATACION NEUROGENICA, MIGRANA, CEFALEA EN RACIMO, ENTRE OTRAS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52743803P | 2003-12-05 | 2003-12-05 | |
US11/004,706 US7569578B2 (en) | 2003-12-05 | 2004-12-03 | Heterocyclic anti-migraine agents |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050670A1 true PE20050670A1 (es) | 2005-09-25 |
Family
ID=34680800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004001195A PE20050670A1 (es) | 2003-12-05 | 2004-12-06 | Agentes antimigrana heterociclicos |
Country Status (17)
Country | Link |
---|---|
US (1) | US7569578B2 (es) |
EP (1) | EP1689738A2 (es) |
JP (1) | JP2007516967A (es) |
KR (1) | KR20070026339A (es) |
AR (1) | AR046787A1 (es) |
AU (1) | AU2004297230A1 (es) |
BR (1) | BRPI0417337A (es) |
CA (1) | CA2549401A1 (es) |
CO (1) | CO5690595A2 (es) |
IL (1) | IL176043A0 (es) |
IS (1) | IS8483A (es) |
MX (1) | MXPA06005970A (es) |
NO (1) | NO20062489L (es) |
PE (1) | PE20050670A1 (es) |
RU (1) | RU2006124026A (es) |
TW (1) | TW200524601A (es) |
WO (1) | WO2005056550A2 (es) |
Families Citing this family (38)
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BRPI0311812B8 (pt) * | 2002-06-05 | 2021-05-25 | Bristol Myers Squibb Co | antagonistas de receptor de peptídeo relacionado com o gene de calcitonina, composição farmacêutica e seu uso |
US7220862B2 (en) * | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
US7842808B2 (en) * | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
AR046787A1 (es) | 2003-12-05 | 2005-12-21 | Bristol Myers Squibb Co | Agentes antimigrana heterociclicos |
JP4769082B2 (ja) * | 2003-12-17 | 2011-09-07 | 武田薬品工業株式会社 | ウレア誘導体、その製造法及び用途 |
TW200533398A (en) * | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US7384931B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
US7384930B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
US7449586B2 (en) * | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
US7834007B2 (en) * | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
US8168592B2 (en) | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
US8067447B2 (en) | 2006-11-01 | 2011-11-29 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US8198311B2 (en) * | 2006-11-01 | 2012-06-12 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
DE102007002717A1 (de) | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Heterocyclische Indazolderivate |
DE102007022565A1 (de) | 2007-05-14 | 2008-11-20 | Merck Patent Gmbh | Heterocyclische Indazolderivate |
EP2294062B1 (en) | 2008-06-09 | 2013-08-21 | Bayer Intellectual Property GmbH | Substituted 4- (indazolyl) -1,4-dihydropyridines and methods of use thereof |
DE102008038222A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Indazol-5-carbonsäurehydrazid-derivate |
DE102008038220A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Oxadiazolderivate |
DE102008038221A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-Azaindolderivate |
EP2398790B1 (en) | 2009-02-18 | 2013-07-03 | Bayer Intellectual Property GmbH | Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof |
JP5674211B2 (ja) | 2009-07-10 | 2015-02-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法 |
EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
CN104662015B (zh) | 2012-06-20 | 2017-03-29 | 诺华股份有限公司 | 补体途径调节剂及其用途 |
WO2014062548A1 (en) | 2012-10-18 | 2014-04-24 | Bristol-Myers Squibb Company | Tetrahydroimdidazopyrazine derivatives as cgrp receptor antagonists |
EA030814B1 (ru) | 2012-11-20 | 2018-10-31 | Мериал, Инк. | Антигельминтные соединения, композиции и способы их применения |
AU2014316682B2 (en) | 2013-09-06 | 2018-11-22 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole derivatives as immunomodulators |
HRP20220258T1 (hr) * | 2015-03-10 | 2022-04-29 | Aurigene Discovery Technologies Limited | Sastavi 1,2,4-oksadiazola i tiadiazola kao imunomodulatora |
JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
GB201519196D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
GB201519194D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
GB201519195D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
WO2019073399A1 (en) | 2017-10-11 | 2019-04-18 | Aurigene Discovery Technologies Limited | CRYSTALLINE FORMS OF 1,2,4-OXADIAZOLE SUBSTITUTED IN POSITION 3 |
US11497734B2 (en) | 2017-11-03 | 2022-11-15 | Aurigene Discovery Technologies Limited | Dual inhibitors of TIM-3 and PD-1 pathways |
JP7378395B2 (ja) | 2017-11-06 | 2023-11-13 | オーリジーン オンコロジー リミテッド | 免疫調節のためのコンジョイントセラピー |
EP3737699A1 (en) | 2018-01-12 | 2020-11-18 | Amgen Inc. | Pac1 antibodies and uses thereof |
WO2022172829A1 (ja) * | 2021-02-15 | 2022-08-18 | 株式会社カネカ | 光学活性インダゾリルアラニン又はインダゾリルアルデヒドの製造方法 |
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DE102004019492A1 (de) | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7696195B2 (en) | 2004-04-22 | 2010-04-13 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
DE102004027912A1 (de) | 2004-06-09 | 2005-12-29 | Grünenthal GmbH | Substituierte Cyclopenten-Verbindungen |
US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
-
2004
- 2004-12-03 AR ARP040104529A patent/AR046787A1/es unknown
- 2004-12-03 US US11/004,706 patent/US7569578B2/en active Active
- 2004-12-03 TW TW093137539A patent/TW200524601A/zh unknown
- 2004-12-06 RU RU2006124026/04A patent/RU2006124026A/ru not_active Application Discontinuation
- 2004-12-06 MX MXPA06005970A patent/MXPA06005970A/es not_active Application Discontinuation
- 2004-12-06 JP JP2006542841A patent/JP2007516967A/ja not_active Withdrawn
- 2004-12-06 KR KR1020067010916A patent/KR20070026339A/ko not_active Application Discontinuation
- 2004-12-06 CA CA002549401A patent/CA2549401A1/en not_active Abandoned
- 2004-12-06 EP EP04813096A patent/EP1689738A2/en not_active Withdrawn
- 2004-12-06 PE PE2004001195A patent/PE20050670A1/es not_active Application Discontinuation
- 2004-12-06 BR BRPI0417337-6A patent/BRPI0417337A/pt not_active IP Right Cessation
- 2004-12-06 WO PCT/US2004/040721 patent/WO2005056550A2/en active Application Filing
- 2004-12-06 AU AU2004297230A patent/AU2004297230A1/en not_active Abandoned
-
2006
- 2006-05-26 IS IS8483A patent/IS8483A/is unknown
- 2006-05-31 NO NO20062489A patent/NO20062489L/no not_active Application Discontinuation
- 2006-05-31 IL IL176043A patent/IL176043A0/en unknown
- 2006-06-01 CO CO06052775A patent/CO5690595A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2006124026A (ru) | 2008-01-27 |
IS8483A (is) | 2006-05-26 |
AR046787A1 (es) | 2005-12-21 |
EP1689738A2 (en) | 2006-08-16 |
JP2007516967A (ja) | 2007-06-28 |
AU2004297230A1 (en) | 2005-06-23 |
WO2005056550A3 (en) | 2005-07-14 |
MXPA06005970A (es) | 2006-07-06 |
US7569578B2 (en) | 2009-08-04 |
NO20062489L (no) | 2006-06-14 |
CO5690595A2 (es) | 2006-10-31 |
CA2549401A1 (en) | 2005-06-23 |
US20050153959A1 (en) | 2005-07-14 |
WO2005056550A2 (en) | 2005-06-23 |
IL176043A0 (en) | 2006-10-05 |
TW200524601A (en) | 2005-08-01 |
KR20070026339A (ko) | 2007-03-08 |
BRPI0417337A (pt) | 2007-04-17 |
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