BRPI0417337A - agentes anti-enxaqueca heterocìclicos - Google Patents

agentes anti-enxaqueca heterocìclicos

Info

Publication number
BRPI0417337A
BRPI0417337A BRPI0417337-6A BRPI0417337A BRPI0417337A BR PI0417337 A BRPI0417337 A BR PI0417337A BR PI0417337 A BRPI0417337 A BR PI0417337A BR PI0417337 A BRPI0417337 A BR PI0417337A
Authority
BR
Brazil
Prior art keywords
treatment
methods
cgrp
migraine agents
migraine
Prior art date
Application number
BRPI0417337-6A
Other languages
English (en)
Inventor
Guanglin Luo
Ling Chen
Andrew P Degnan
Gene M Dubowchik
John E Macor
George Tora
Prasad V Chaturvedula
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BRPI0417337A publication Critical patent/BRPI0417337A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"AGENTES ANTI-ENXAQUECA HETEROCìCLICOS". A presente invenção se refere a compostos de Fórmula (I) como antagonistas de receptores peptídicos relacionados com o gene da calcitonina ('receptor de CGRP'), composições farmacêuticas compreendendo os mesmos, métodos para identificar os mesmos, métodos de tratamento usando os mesmos e sua aplicação em terapia para tratamento de vasodilatação neurogênica, inflamação neurogênica, enxaqueca e outras cefaléias, agressão térmica, choque circulatório, acessos de calor associados com a menopausa, doenças inflamatórias das vias aéreas, tais como asma e doença pulmonar obstrutiva crónica (COPD), e outras condições cujo tratamento pode ser efetuado pelo antagonismo de receptores de CGRP.
BRPI0417337-6A 2003-12-05 2004-12-06 agentes anti-enxaqueca heterocìclicos BRPI0417337A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52743803P 2003-12-05 2003-12-05
US11/004,706 US7569578B2 (en) 2003-12-05 2004-12-03 Heterocyclic anti-migraine agents
PCT/US2004/040721 WO2005056550A2 (en) 2003-12-05 2004-12-06 Heterocyclic anti-migraine agents

Publications (1)

Publication Number Publication Date
BRPI0417337A true BRPI0417337A (pt) 2007-04-17

Family

ID=34680800

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417337-6A BRPI0417337A (pt) 2003-12-05 2004-12-06 agentes anti-enxaqueca heterocìclicos

Country Status (17)

Country Link
US (1) US7569578B2 (pt)
EP (1) EP1689738A2 (pt)
JP (1) JP2007516967A (pt)
KR (1) KR20070026339A (pt)
AR (1) AR046787A1 (pt)
AU (1) AU2004297230A1 (pt)
BR (1) BRPI0417337A (pt)
CA (1) CA2549401A1 (pt)
CO (1) CO5690595A2 (pt)
IL (1) IL176043A0 (pt)
IS (1) IS8483A (pt)
MX (1) MXPA06005970A (pt)
NO (1) NO20062489L (pt)
PE (1) PE20050670A1 (pt)
RU (1) RU2006124026A (pt)
TW (1) TW200524601A (pt)
WO (1) WO2005056550A2 (pt)

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BRPI0311812B8 (pt) * 2002-06-05 2021-05-25 Bristol Myers Squibb Co antagonistas de receptor de peptídeo relacionado com o gene de calcitonina, composição farmacêutica e seu uso
US7220862B2 (en) * 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
US7842808B2 (en) * 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
AR046787A1 (es) 2003-12-05 2005-12-21 Bristol Myers Squibb Co Agentes antimigrana heterociclicos
JP4769082B2 (ja) * 2003-12-17 2011-09-07 武田薬品工業株式会社 ウレア誘導体、その製造法及び用途
TW200533398A (en) * 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
US7384931B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) * 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
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US8198311B2 (en) * 2006-11-01 2012-06-12 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
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Also Published As

Publication number Publication date
RU2006124026A (ru) 2008-01-27
IS8483A (is) 2006-05-26
AR046787A1 (es) 2005-12-21
EP1689738A2 (en) 2006-08-16
JP2007516967A (ja) 2007-06-28
AU2004297230A1 (en) 2005-06-23
WO2005056550A3 (en) 2005-07-14
MXPA06005970A (es) 2006-07-06
US7569578B2 (en) 2009-08-04
NO20062489L (no) 2006-06-14
CO5690595A2 (es) 2006-10-31
CA2549401A1 (en) 2005-06-23
US20050153959A1 (en) 2005-07-14
PE20050670A1 (es) 2005-09-25
WO2005056550A2 (en) 2005-06-23
IL176043A0 (en) 2006-10-05
TW200524601A (en) 2005-08-01
KR20070026339A (ko) 2007-03-08

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