PE20050122A1 - Derivados de glutaramida sustituidos con ciclopentilo como inhibidores de la endopeptidasa neutra (nep) - Google Patents

Derivados de glutaramida sustituidos con ciclopentilo como inhibidores de la endopeptidasa neutra (nep)

Info

Publication number
PE20050122A1
PE20050122A1 PE2004000022A PE2004000022A PE20050122A1 PE 20050122 A1 PE20050122 A1 PE 20050122A1 PE 2004000022 A PE2004000022 A PE 2004000022A PE 2004000022 A PE2004000022 A PE 2004000022A PE 20050122 A1 PE20050122 A1 PE 20050122A1
Authority
PE
Peru
Prior art keywords
alkyl
nep
carboxy
inhibitors
derivatives substituted
Prior art date
Application number
PE2004000022A
Other languages
English (en)
Inventor
Kevin Neil Dack
Dafydd Rhys Owen
Christine Anne Louise Watson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20050122A1 publication Critical patent/PE20050122A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/101,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A DERIVADOS DE GLUTARAMIDA SUSTITUIDOS CON CICLOPENTILO DE FORMULA I DONDE R1 ES ALQUILO C1-C6, ALCOXI-C1-C6-ALQUILO C1-C3, ENTRE OTROS; R2 ES H, ALQUILO C1-C6; L ES UN ANILLO HETEROCICLICO AROMATICO CON ALQUILO C1-C6, HALO; R3 ES ALQUILO C1-C6 CON HALO, ALCOXI, HALOALCOXI, ALQUILTIO, HALOALQUILTIO, NITRILO, ENTRE OTROS; R4 Y R5 SON H O UNO DE R4 Y R5 ES H Y EL OTRO ES UN GRUPO FORMADOR DE ESTER; p ES 0-2; q ES 1-2; A ES ALQUILO, LINEAL O RAMIFICADO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO (2S)-2-{1-[(1S)-1-CARBOXI-2-(4-METIL-5-FENILOXAZOL-2-IL)ETOXI-CARBAMOIL]CICLOPENTILMETIL}-4-METOXIBUTIRICO, ACIDO (2S)-2-(1-{(1S)-1-CARBOXI-2-(5-(4-FLUOROFENIL)OXAZOL-2-IL)ETIL-CARBAMOIL]CICLOPENTILMETIL}-4-METOXIBUTIRICO, ACIDO (2R)-2-{1-[(1S)-1-CARBOXI-2-(5-FENILOXAZOL-2-IL)ETILCARBAMOIL]CICLOPENTILMETIL}PENTANOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA ENDOPEPTIDASA NEUTRA (NEP) Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES
PE2004000022A 2002-12-23 2004-01-05 Derivados de glutaramida sustituidos con ciclopentilo como inhibidores de la endopeptidasa neutra (nep) PE20050122A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0230025.9A GB0230025D0 (en) 2002-12-23 2002-12-23 Novel pharmaceuticals

Publications (1)

Publication Number Publication Date
PE20050122A1 true PE20050122A1 (es) 2005-01-24

Family

ID=9950328

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000022A PE20050122A1 (es) 2002-12-23 2004-01-05 Derivados de glutaramida sustituidos con ciclopentilo como inhibidores de la endopeptidasa neutra (nep)

Country Status (15)

Country Link
US (1) US20040138274A1 (es)
EP (1) EP1578735A1 (es)
JP (1) JP2006515297A (es)
AR (1) AR042647A1 (es)
AU (1) AU2003285641A1 (es)
BR (1) BR0317644A (es)
CA (1) CA2511360A1 (es)
GB (1) GB0230025D0 (es)
GT (1) GT200300291A (es)
NL (1) NL1025116C2 (es)
PA (1) PA8593601A1 (es)
PE (1) PE20050122A1 (es)
TW (1) TW200420548A (es)
UY (1) UY28145A1 (es)
WO (1) WO2004056787A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1756074A4 (en) * 2004-05-04 2010-05-19 Merck Sharp & Dohme 1,2,4-OXADIAZOLE DERIVATIVES AS INHIBITORS OF DIPEPTIDYLPEPTIDASE-IV IN THE TREATMENT OR PREVENTION OF DIABETES
WO2005123702A1 (en) * 2004-06-15 2005-12-29 Pfizer Limited Neutral endopeptidase inhibitor polymorph
WO2007016361A2 (en) 2005-07-29 2007-02-08 Concert Pharmaceuticals Inc. Novel pharmaceutical compounds
AR057882A1 (es) * 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
CA2691003A1 (en) * 2007-06-26 2008-12-31 Lexicon Pharmaceuticals, Inc. Methods of treating serotonin-mediated diseases and disorders
MX2016008247A (es) * 2013-12-20 2016-10-21 Novartis Ag Derivados de acido heteroaril butanoico como inhibidores de lta4h.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
EE200300469A (et) * 2001-03-28 2004-02-16 Pfizer Inc. N-fenpropüültsüklopentüülasendatud glutaramiidi derivaadid kui NEP inhibiitorid FSAD puhul

Also Published As

Publication number Publication date
WO2004056787A1 (en) 2004-07-08
EP1578735A1 (en) 2005-09-28
AU2003285641A1 (en) 2004-07-14
AR042647A1 (es) 2005-06-29
NL1025116C2 (nl) 2004-10-18
US20040138274A1 (en) 2004-07-15
JP2006515297A (ja) 2006-05-25
NL1025116A1 (nl) 2004-06-24
CA2511360A1 (en) 2004-07-08
GB0230025D0 (en) 2003-01-29
GT200300291A (es) 2004-08-13
PA8593601A1 (es) 2005-05-24
TW200420548A (en) 2004-10-16
BR0317644A (pt) 2005-12-06
UY28145A1 (es) 2004-07-30

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