PE20050122A1 - Derivados de glutaramida sustituidos con ciclopentilo como inhibidores de la endopeptidasa neutra (nep) - Google Patents
Derivados de glutaramida sustituidos con ciclopentilo como inhibidores de la endopeptidasa neutra (nep)Info
- Publication number
- PE20050122A1 PE20050122A1 PE2004000022A PE2004000022A PE20050122A1 PE 20050122 A1 PE20050122 A1 PE 20050122A1 PE 2004000022 A PE2004000022 A PE 2004000022A PE 2004000022 A PE2004000022 A PE 2004000022A PE 20050122 A1 PE20050122 A1 PE 20050122A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- nep
- carboxy
- inhibitors
- derivatives substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A DERIVADOS DE GLUTARAMIDA SUSTITUIDOS CON CICLOPENTILO DE FORMULA I DONDE R1 ES ALQUILO C1-C6, ALCOXI-C1-C6-ALQUILO C1-C3, ENTRE OTROS; R2 ES H, ALQUILO C1-C6; L ES UN ANILLO HETEROCICLICO AROMATICO CON ALQUILO C1-C6, HALO; R3 ES ALQUILO C1-C6 CON HALO, ALCOXI, HALOALCOXI, ALQUILTIO, HALOALQUILTIO, NITRILO, ENTRE OTROS; R4 Y R5 SON H O UNO DE R4 Y R5 ES H Y EL OTRO ES UN GRUPO FORMADOR DE ESTER; p ES 0-2; q ES 1-2; A ES ALQUILO, LINEAL O RAMIFICADO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO (2S)-2-{1-[(1S)-1-CARBOXI-2-(4-METIL-5-FENILOXAZOL-2-IL)ETOXI-CARBAMOIL]CICLOPENTILMETIL}-4-METOXIBUTIRICO, ACIDO (2S)-2-(1-{(1S)-1-CARBOXI-2-(5-(4-FLUOROFENIL)OXAZOL-2-IL)ETIL-CARBAMOIL]CICLOPENTILMETIL}-4-METOXIBUTIRICO, ACIDO (2R)-2-{1-[(1S)-1-CARBOXI-2-(5-FENILOXAZOL-2-IL)ETILCARBAMOIL]CICLOPENTILMETIL}PENTANOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA ENDOPEPTIDASA NEUTRA (NEP) Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0230025.9A GB0230025D0 (en) | 2002-12-23 | 2002-12-23 | Novel pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050122A1 true PE20050122A1 (es) | 2005-01-24 |
Family
ID=9950328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000022A PE20050122A1 (es) | 2002-12-23 | 2004-01-05 | Derivados de glutaramida sustituidos con ciclopentilo como inhibidores de la endopeptidasa neutra (nep) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040138274A1 (es) |
| EP (1) | EP1578735A1 (es) |
| JP (1) | JP2006515297A (es) |
| AR (1) | AR042647A1 (es) |
| AU (1) | AU2003285641A1 (es) |
| BR (1) | BR0317644A (es) |
| CA (1) | CA2511360A1 (es) |
| GB (1) | GB0230025D0 (es) |
| GT (1) | GT200300291A (es) |
| NL (1) | NL1025116C2 (es) |
| PA (1) | PA8593601A1 (es) |
| PE (1) | PE20050122A1 (es) |
| TW (1) | TW200420548A (es) |
| UY (1) | UY28145A1 (es) |
| WO (1) | WO2004056787A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1756074A4 (en) * | 2004-05-04 | 2010-05-19 | Merck Sharp & Dohme | 1,2,4-OXADIAZOLE DERIVATIVES AS INHIBITORS OF DIPEPTIDYLPEPTIDASE-IV IN THE TREATMENT OR PREVENTION OF DIABETES |
| WO2005123702A1 (en) * | 2004-06-15 | 2005-12-29 | Pfizer Limited | Neutral endopeptidase inhibitor polymorph |
| WO2007016361A2 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| AR057882A1 (es) * | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| CA2691003A1 (en) * | 2007-06-26 | 2008-12-31 | Lexicon Pharmaceuticals, Inc. | Methods of treating serotonin-mediated diseases and disorders |
| MX2016008247A (es) * | 2013-12-20 | 2016-10-21 | Novartis Ag | Derivados de acido heteroaril butanoico como inhibidores de lta4h. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8820844D0 (en) * | 1988-09-05 | 1988-10-05 | Pfizer Ltd | Therapeutic agents |
| EE200300469A (et) * | 2001-03-28 | 2004-02-16 | Pfizer Inc. | N-fenpropüültsüklopentüülasendatud glutaramiidi derivaadid kui NEP inhibiitorid FSAD puhul |
-
2002
- 2002-12-23 GB GBGB0230025.9A patent/GB0230025D0/en not_active Ceased
-
2003
- 2003-12-12 CA CA002511360A patent/CA2511360A1/en not_active Abandoned
- 2003-12-12 WO PCT/IB2003/005981 patent/WO2004056787A1/en not_active Application Discontinuation
- 2003-12-12 AU AU2003285641A patent/AU2003285641A1/en not_active Abandoned
- 2003-12-12 JP JP2004561854A patent/JP2006515297A/ja active Pending
- 2003-12-12 BR BR0317644-4A patent/BR0317644A/pt not_active IP Right Cessation
- 2003-12-12 EP EP03778633A patent/EP1578735A1/en not_active Withdrawn
- 2003-12-18 US US10/739,426 patent/US20040138274A1/en not_active Abandoned
- 2003-12-18 GT GT200300291A patent/GT200300291A/es unknown
- 2003-12-22 AR ARP030104772A patent/AR042647A1/es unknown
- 2003-12-22 UY UY28145A patent/UY28145A1/es not_active Application Discontinuation
- 2003-12-22 PA PA20038593601A patent/PA8593601A1/es unknown
- 2003-12-22 TW TW092136393A patent/TW200420548A/zh unknown
- 2003-12-23 NL NL1025116A patent/NL1025116C2/nl not_active IP Right Cessation
-
2004
- 2004-01-05 PE PE2004000022A patent/PE20050122A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004056787A1 (en) | 2004-07-08 |
| EP1578735A1 (en) | 2005-09-28 |
| AU2003285641A1 (en) | 2004-07-14 |
| AR042647A1 (es) | 2005-06-29 |
| NL1025116C2 (nl) | 2004-10-18 |
| US20040138274A1 (en) | 2004-07-15 |
| JP2006515297A (ja) | 2006-05-25 |
| NL1025116A1 (nl) | 2004-06-24 |
| CA2511360A1 (en) | 2004-07-08 |
| GB0230025D0 (en) | 2003-01-29 |
| GT200300291A (es) | 2004-08-13 |
| PA8593601A1 (es) | 2005-05-24 |
| TW200420548A (en) | 2004-10-16 |
| BR0317644A (pt) | 2005-12-06 |
| UY28145A1 (es) | 2004-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |