AR042647A1 - Ciclopentil glutaramidas y su uso como inhibidor de endopeptidasa neutral - Google Patents
Ciclopentil glutaramidas y su uso como inhibidor de endopeptidasa neutralInfo
- Publication number
- AR042647A1 AR042647A1 ARP030104772A ARP030104772A AR042647A1 AR 042647 A1 AR042647 A1 AR 042647A1 AR P030104772 A ARP030104772 A AR P030104772A AR P030104772 A ARP030104772 A AR P030104772A AR 042647 A1 AR042647 A1 AR 042647A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- halo
- glutaramids
- cyclopentil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a inhibidores de NEP para tratar trastornos cardiovasculares. R1 es alquilo C1-6, alcoxi C1-6-alquilo C1-3 o alcoxi C1-6-alcoxi C1-6-alquilo C1-3; R2 es H o alquilo C1-6; L es un anillo heterocíclico aromático, opcionalmente sustituido con alquilo C1-6 o halo; R3 es alquilo C1-6 opcionalmente sustituido con un grupo halo, alcoxi, haloalcoxi, alquiltio, haloalquiltio o nitrilo, o R3 es fenilo o heterociclilo aromático, cada uno de los cuales puede estar independientemente sustituido con uno o más grupos alquilo, halo, haloalquilo, alcoxi, haloalcoxi, alquiltio, haloalquiltio o nitrilo; R4 y R5 son ambos H o uno de R4 y R5 es H y el otro es un grupo formador de éster biolábil que en el cuerpo de un paciente se reemplaza por H; p es 0, 1 o 2 y q es 1 o 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0230025.9A GB0230025D0 (en) | 2002-12-23 | 2002-12-23 | Novel pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042647A1 true AR042647A1 (es) | 2005-06-29 |
Family
ID=9950328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104772A AR042647A1 (es) | 2002-12-23 | 2003-12-22 | Ciclopentil glutaramidas y su uso como inhibidor de endopeptidasa neutral |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040138274A1 (es) |
| EP (1) | EP1578735A1 (es) |
| JP (1) | JP2006515297A (es) |
| AR (1) | AR042647A1 (es) |
| AU (1) | AU2003285641A1 (es) |
| BR (1) | BR0317644A (es) |
| CA (1) | CA2511360A1 (es) |
| GB (1) | GB0230025D0 (es) |
| GT (1) | GT200300291A (es) |
| NL (1) | NL1025116C2 (es) |
| PA (1) | PA8593601A1 (es) |
| PE (1) | PE20050122A1 (es) |
| TW (1) | TW200420548A (es) |
| UY (1) | UY28145A1 (es) |
| WO (1) | WO2004056787A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005108382A1 (en) * | 2004-05-04 | 2005-11-17 | Merck & Co., Inc. | 1,2,4-oxadiazole derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| WO2005123702A1 (en) * | 2004-06-15 | 2005-12-29 | Pfizer Limited | Neutral endopeptidase inhibitor polymorph |
| AU2006275702A1 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| MX2009013990A (es) * | 2007-06-26 | 2010-03-30 | Lexicon Pharmaceuticals Inc | Metodos para tratar enfermedades y trastornos mediados por serotonina. |
| LT3083564T (lt) * | 2013-12-20 | 2018-09-25 | Novartis Ag | Heteroarilo butano rūgšties dariniai, kaip lta4h inhibitoriai |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8820844D0 (en) * | 1988-09-05 | 1988-10-05 | Pfizer Ltd | Therapeutic agents |
| WO2002079143A1 (en) * | 2001-03-28 | 2002-10-10 | Pfizer Limited | N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad |
-
2002
- 2002-12-23 GB GBGB0230025.9A patent/GB0230025D0/en not_active Ceased
-
2003
- 2003-12-12 WO PCT/IB2003/005981 patent/WO2004056787A1/en not_active Application Discontinuation
- 2003-12-12 BR BR0317644-4A patent/BR0317644A/pt not_active IP Right Cessation
- 2003-12-12 AU AU2003285641A patent/AU2003285641A1/en not_active Abandoned
- 2003-12-12 JP JP2004561854A patent/JP2006515297A/ja active Pending
- 2003-12-12 CA CA002511360A patent/CA2511360A1/en not_active Abandoned
- 2003-12-12 EP EP03778633A patent/EP1578735A1/en not_active Withdrawn
- 2003-12-18 GT GT200300291A patent/GT200300291A/es unknown
- 2003-12-18 US US10/739,426 patent/US20040138274A1/en not_active Abandoned
- 2003-12-22 AR ARP030104772A patent/AR042647A1/es unknown
- 2003-12-22 UY UY28145A patent/UY28145A1/es not_active Application Discontinuation
- 2003-12-22 PA PA20038593601A patent/PA8593601A1/es unknown
- 2003-12-22 TW TW092136393A patent/TW200420548A/zh unknown
- 2003-12-23 NL NL1025116A patent/NL1025116C2/nl not_active IP Right Cessation
-
2004
- 2004-01-05 PE PE2004000022A patent/PE20050122A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT200300291A (es) | 2004-08-13 |
| AU2003285641A1 (en) | 2004-07-14 |
| NL1025116C2 (nl) | 2004-10-18 |
| TW200420548A (en) | 2004-10-16 |
| JP2006515297A (ja) | 2006-05-25 |
| PE20050122A1 (es) | 2005-01-24 |
| GB0230025D0 (en) | 2003-01-29 |
| EP1578735A1 (en) | 2005-09-28 |
| UY28145A1 (es) | 2004-07-30 |
| US20040138274A1 (en) | 2004-07-15 |
| NL1025116A1 (nl) | 2004-06-24 |
| WO2004056787A1 (en) | 2004-07-08 |
| CA2511360A1 (en) | 2004-07-08 |
| BR0317644A (pt) | 2005-12-06 |
| PA8593601A1 (es) | 2005-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |