PE20060458A1 - Tetrahidroisoquinolinas sustituidas en calidad de inhibidores de mpm y procedimiento para su preparacion - Google Patents
Tetrahidroisoquinolinas sustituidas en calidad de inhibidores de mpm y procedimiento para su preparacionInfo
- Publication number
- PE20060458A1 PE20060458A1 PE2005000688A PE2005000688A PE20060458A1 PE 20060458 A1 PE20060458 A1 PE 20060458A1 PE 2005000688 A PE2005000688 A PE 2005000688A PE 2005000688 A PE2005000688 A PE 2005000688A PE 20060458 A1 PE20060458 A1 PE 20060458A1
- Authority
- PE
- Peru
- Prior art keywords
- mpm
- tetrahydroisoquinoline
- tetrahydroisoquinolins
- inhibitors
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE TETRAHIDROISOQUINOLINA DE FORMULA I, DONDE R1, R2 Y R3 SON H, F, NO2, ENTRE OTROS; A ES C(O)R5 O CH2SH; R5 ES OR6, NR6R7 O NR6OH; R6 Y R7 SON H, ALQUILO C1-C6; n ES 0, 1 O 2; L ES O, NR14, ENTRE OTROS; R14 ES H O ALQUILO C1-C6; q ES 1, 2, 3 O 4; R4 ES FENILO O HETEROARILO DE 5 A 14 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(6-FENOXIPIRIDINA-3-SULFONIL)-1,2,3,4-TETRAHIDROISOQUINOLINA-1-HIDROXICARBAMIDA, 2-(6-MORFOLIN-4-ILPIRIDA-3-SULFONIL)-1,2,3,4-TETRAHIDROISOQUINOLINA-1-HIDROXICARBAMIDA, 2-(2-BIFENIL-4-ILETANOSULFONIL)-1,2,3,4-TETRAHIDROISOQUINOLINA-1-HIDROXICARBAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS EN CUYO PROGRESO ESTA IMPLICADA UNA ACTIVIDAD REFORZADA DE LAS METALOPROTEINASAS DE LA MATRIZ (MPM)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004031850A DE102004031850A1 (de) | 2004-06-30 | 2004-06-30 | Substituirte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060458A1 true PE20060458A1 (es) | 2006-05-29 |
Family
ID=34971773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000688A PE20060458A1 (es) | 2004-06-30 | 2005-06-16 | Tetrahidroisoquinolinas sustituidas en calidad de inhibidores de mpm y procedimiento para su preparacion |
Country Status (15)
Country | Link |
---|---|
US (1) | US20070203118A1 (es) |
EP (1) | EP1763516A2 (es) |
JP (1) | JP2008504315A (es) |
KR (1) | KR20070026679A (es) |
CN (1) | CN101006059A (es) |
AU (1) | AU2005259633A1 (es) |
BR (1) | BRPI0511323A (es) |
CA (1) | CA2572125A1 (es) |
DE (1) | DE102004031850A1 (es) |
IL (1) | IL179974A0 (es) |
MX (1) | MXPA06014366A (es) |
PE (1) | PE20060458A1 (es) |
TW (1) | TW200612940A (es) |
UY (1) | UY28993A1 (es) |
WO (1) | WO2006002763A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004031620A1 (de) * | 2004-06-30 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | 4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln |
DE102005015040A1 (de) * | 2005-03-31 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
GB0706072D0 (en) * | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
BR112017018755B1 (pt) * | 2015-03-02 | 2023-05-02 | Amgen Inc | Compostos bicíclicos de cetona sulfonamida e composição farmacêutica relacionada |
US10597378B2 (en) | 2017-09-08 | 2020-03-24 | National Health Research Institutes | Tetrahydroisoquinolines for use as MOR/NOP dual agonists |
TWI650313B (zh) * | 2017-09-08 | 2019-02-11 | 財團法人國家衛生研究院 | 雜環化合物及其用途 |
CN110835639B (zh) * | 2018-08-16 | 2021-08-10 | 苏州同力生物医药有限公司 | 一种制备(s)-1,2,3,4-四氢异喹啉-1-甲酸及其衍生物的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19542189A1 (de) * | 1995-11-13 | 1997-05-15 | Hoechst Ag | Cyclische N-substituierte alpha-Iminohydroxamsäuren |
ATE213232T1 (de) * | 1995-11-13 | 2002-02-15 | Hoechst Ag | Cyclische und heterocyclische n-substituierte alpha-iminohydroxam- und carbonsäuren |
US6770647B2 (en) * | 2001-08-17 | 2004-08-03 | Bristol-Myers Squibb Pharma Company | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
DE10344936A1 (de) * | 2003-09-27 | 2005-04-21 | Aventis Pharma Gmbh | Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen |
US7205315B2 (en) * | 2003-09-27 | 2007-04-17 | Sanofi-Aventis Deutschland Gmbh | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases |
-
2004
- 2004-06-30 DE DE102004031850A patent/DE102004031850A1/de not_active Ceased
-
2005
- 2005-06-15 CN CNA2005800220960A patent/CN101006059A/zh active Pending
- 2005-06-15 BR BRPI0511323-7A patent/BRPI0511323A/pt not_active IP Right Cessation
- 2005-06-15 AU AU2005259633A patent/AU2005259633A1/en not_active Abandoned
- 2005-06-15 JP JP2007518484A patent/JP2008504315A/ja not_active Abandoned
- 2005-06-15 EP EP05757350A patent/EP1763516A2/de not_active Withdrawn
- 2005-06-15 MX MXPA06014366A patent/MXPA06014366A/es not_active Application Discontinuation
- 2005-06-15 CA CA002572125A patent/CA2572125A1/en not_active Abandoned
- 2005-06-15 WO PCT/EP2005/006415 patent/WO2006002763A2/de not_active Application Discontinuation
- 2005-06-15 KR KR1020067027661A patent/KR20070026679A/ko not_active Application Discontinuation
- 2005-06-16 PE PE2005000688A patent/PE20060458A1/es not_active Application Discontinuation
- 2005-06-28 TW TW094121519A patent/TW200612940A/zh unknown
- 2005-06-30 UY UY28993A patent/UY28993A1/es unknown
-
2006
- 2006-12-11 IL IL179974A patent/IL179974A0/en unknown
- 2006-12-19 US US11/612,938 patent/US20070203118A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20070203118A1 (en) | 2007-08-30 |
CA2572125A1 (en) | 2006-01-12 |
JP2008504315A (ja) | 2008-02-14 |
DE102004031850A1 (de) | 2006-01-26 |
TW200612940A (en) | 2006-05-01 |
EP1763516A2 (de) | 2007-03-21 |
MXPA06014366A (es) | 2007-03-08 |
WO2006002763A3 (de) | 2006-03-16 |
WO2006002763A2 (de) | 2006-01-12 |
KR20070026679A (ko) | 2007-03-08 |
BRPI0511323A (pt) | 2007-12-04 |
CN101006059A (zh) | 2007-07-25 |
UY28993A1 (es) | 2006-01-31 |
IL179974A0 (en) | 2007-05-15 |
AU2005259633A1 (en) | 2006-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |