BR0317644A - Cilopentil glutaramidas e seu uso como inibidores de endo-peptidase neutros - Google Patents

Cilopentil glutaramidas e seu uso como inibidores de endo-peptidase neutros

Info

Publication number
BR0317644A
BR0317644A BR0317644-4A BR0317644A BR0317644A BR 0317644 A BR0317644 A BR 0317644A BR 0317644 A BR0317644 A BR 0317644A BR 0317644 A BR0317644 A BR 0317644A
Authority
BR
Brazil
Prior art keywords
alkyl
hydrogen
glutaramides
halo
alkoxy
Prior art date
Application number
BR0317644-4A
Other languages
English (en)
Inventor
Kevin Neil Dack
Dafydd Rhys Owen
Christine Anne Louise Watson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR0317644A publication Critical patent/BR0317644A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"CILOPENTIL GLUTARAMIDAS E SEU USO COMO INIBIDORES DE ENDOPEPTIDASE NEUTROS". A presente invenção refere-se a com inibidores da NEP para o tratamento de distúrbios cardiovasculares em que R¬ 1¬ é C~ 1~-C~ 6~alquila, C~ 1~-C~ 6~alcoxiC~ 1~-C~ 3~alquila ou C~ 1~-C~ 6~alcoxiC~ 1~-C~ 6~alcoxiC~ 1~-C~ 3~alquila; R¬ 2¬ é hidrogênio ou C~ 1~-C~ 6~alquila; L é um anel heterocíclico aromático, substituído opcionalmente por C~ 1~-C~ 6~alquila ou halo; R~ 3~ é C~ 1~-C~ 6~alquila substituída opcionalmente por grupo halo, alcóxi, haloalcóxi, alquiltio, haloalquiltio ou nitrila, ou R¬ 3¬ é fenila ou heterociclila aromática cada um dos quais pode ser substituído independentemente por um ou mais grupos alquila, halo, haloalquila, alcóxi, haloalcóxi, alquiltio, haloalquiltio ou nitrila; R¬ 4¬ e R¬ 5¬ são ambos hidrogênio, ou um dos R¬ 4¬ e R¬ 5¬ é hidrogênio e o outro é um grupo formador de éster biolábil que no organismo de um paciente é substituído por hidrogênio; p é 0, 1 ou 2; e q é 1 ou 2.
BR0317644-4A 2002-12-23 2003-12-12 Cilopentil glutaramidas e seu uso como inibidores de endo-peptidase neutros BR0317644A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0230025.9A GB0230025D0 (en) 2002-12-23 2002-12-23 Novel pharmaceuticals
PCT/IB2003/005981 WO2004056787A1 (en) 2002-12-23 2003-12-12 Cyclopentyl glutaramides and their use as neutral endopeptidase inhibitors

Publications (1)

Publication Number Publication Date
BR0317644A true BR0317644A (pt) 2005-12-06

Family

ID=9950328

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317644-4A BR0317644A (pt) 2002-12-23 2003-12-12 Cilopentil glutaramidas e seu uso como inibidores de endo-peptidase neutros

Country Status (15)

Country Link
US (1) US20040138274A1 (pt)
EP (1) EP1578735A1 (pt)
JP (1) JP2006515297A (pt)
AR (1) AR042647A1 (pt)
AU (1) AU2003285641A1 (pt)
BR (1) BR0317644A (pt)
CA (1) CA2511360A1 (pt)
GB (1) GB0230025D0 (pt)
GT (1) GT200300291A (pt)
NL (1) NL1025116C2 (pt)
PA (1) PA8593601A1 (pt)
PE (1) PE20050122A1 (pt)
TW (1) TW200420548A (pt)
UY (1) UY28145A1 (pt)
WO (1) WO2004056787A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1756074A4 (en) * 2004-05-04 2010-05-19 Merck Sharp & Dohme 1,2,4-OXADIAZOLE DERIVATIVES AS INHIBITORS OF DIPEPTIDYLPEPTIDASE-IV IN THE TREATMENT OR PREVENTION OF DIABETES
WO2005123702A1 (en) * 2004-06-15 2005-12-29 Pfizer Limited Neutral endopeptidase inhibitor polymorph
WO2007016361A2 (en) 2005-07-29 2007-02-08 Concert Pharmaceuticals Inc. Novel pharmaceutical compounds
AR057882A1 (es) * 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
CA2691003A1 (en) * 2007-06-26 2008-12-31 Lexicon Pharmaceuticals, Inc. Methods of treating serotonin-mediated diseases and disorders
MX2016008247A (es) * 2013-12-20 2016-10-21 Novartis Ag Derivados de acido heteroaril butanoico como inhibidores de lta4h.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
EE200300469A (et) * 2001-03-28 2004-02-16 Pfizer Inc. N-fenpropüültsüklopentüülasendatud glutaramiidi derivaadid kui NEP inhibiitorid FSAD puhul

Also Published As

Publication number Publication date
WO2004056787A1 (en) 2004-07-08
EP1578735A1 (en) 2005-09-28
AU2003285641A1 (en) 2004-07-14
AR042647A1 (es) 2005-06-29
NL1025116C2 (nl) 2004-10-18
US20040138274A1 (en) 2004-07-15
PE20050122A1 (es) 2005-01-24
JP2006515297A (ja) 2006-05-25
NL1025116A1 (nl) 2004-06-24
CA2511360A1 (en) 2004-07-08
GB0230025D0 (en) 2003-01-29
GT200300291A (es) 2004-08-13
PA8593601A1 (es) 2005-05-24
TW200420548A (en) 2004-10-16
UY28145A1 (es) 2004-07-30

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Legal Events

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A, 6A E 7A ANUIDADE(S).

B08J Incorrect entry in the gazette republished [chapter 8.10 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2073 DE 28/09/2010. TEXTO CORRETO: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010 E AO DESPACHO 8.10 PUBLICADO NA RPI 2106 DE 17/05/2011.