PE20040669A1 - Derivados de fenilalanina enamida - Google Patents
Derivados de fenilalanina enamidaInfo
- Publication number
- PE20040669A1 PE20040669A1 PE2003000713A PE2003000713A PE20040669A1 PE 20040669 A1 PE20040669 A1 PE 20040669A1 PE 2003000713 A PE2003000713 A PE 2003000713A PE 2003000713 A PE2003000713 A PE 2003000713A PE 20040669 A1 PE20040669 A1 PE 20040669A1
- Authority
- PE
- Peru
- Prior art keywords
- dichloroisonicotinoil
- ilamino
- propanoate
- spiro
- bromo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, SUS SALES, SOLVATOS Y N-OXIDOS DONDE R1 ES -CH3, -(CH2)3CH3, -CH2CH2OH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BUTIL (2S)-2-(2-BROMO-3-OXO-ESPIRO[3.5]NON-1-EN-1-ILAMINO)-3-{4-[(3,5-DICLOROISONICOTINOIL)AMINO]FENIL}PROPANOATO; 2-HIDROXIETIL (2S)-2-(2-BROMO-3-OXO-SPIRO[3.5]NON-1-EN-1-ILAMINO)-3-{4-[(3,5-DICLOROISONICOTINOIL)AMINO]FENIL}PROPANOATO Y METIL (2S)-2-(2-BROMO-3-OXO-SPIRO[3.5]NON-1-EN-1-ILAMINO)-3-{4-[(3,5-DICLOROISONICOTINOIL)AMINO]FENIL}PROPANOATO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHOS COMPUESTOS QUE SON INHIBIDORES DE a4-INTEGRINAS UTILES EN EL TRATAMIENTO Y PROFILAXIS DE ENFERMEDADES QUE INCLUYEN INFLAMACIONES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0216568.6A GB0216568D0 (en) | 2002-07-17 | 2002-07-17 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040669A1 true PE20040669A1 (es) | 2004-09-25 |
Family
ID=9940610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000713A PE20040669A1 (es) | 2002-07-17 | 2003-07-16 | Derivados de fenilalanina enamida |
Country Status (10)
Country | Link |
---|---|
US (1) | US6872719B1 (es) |
EP (1) | EP1524980A1 (es) |
JP (1) | JP2005536504A (es) |
AR (1) | AR040579A1 (es) |
AU (1) | AU2003281162A1 (es) |
CA (1) | CA2492381A1 (es) |
GB (1) | GB0216568D0 (es) |
PE (1) | PE20040669A1 (es) |
TW (1) | TW200404782A (es) |
WO (1) | WO2004006918A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1370531T1 (sl) * | 2001-02-22 | 2007-08-31 | Ucb Pharma Sa | Derivati fenilalanin enamida s ciklobutensko skupino, za uporabo kot integrin inhibitorji |
CA2714335A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
WO2008138591A2 (en) * | 2007-05-14 | 2008-11-20 | Ucb Pharma, S.A. | Bicyclic and heterobicyclic derivatives,processes for preparing them and their uses |
WO2008138615A1 (en) * | 2007-05-16 | 2008-11-20 | Ucb Pharma, S.A. | Bicyclic and heterobicyclic derivatives, processes for preparing them and their uses |
KR20110008086A (ko) | 2008-04-11 | 2011-01-25 | 메리맥 파마슈티컬즈, 인크. | 인간 혈청 알부민 링커 및 그 콘쥬게이트 |
CN102282168A (zh) * | 2008-11-18 | 2011-12-14 | 梅里麦克制药股份有限公司 | 人血清白蛋白接头以及其结合物 |
US20150105278A1 (en) | 2011-10-17 | 2015-04-16 | Westfaelische Wilhelms-Universitaet Muenster | Methods or risk assessment of pml and related apparatus |
US20150202287A1 (en) | 2012-08-30 | 2015-07-23 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
CA3116769C (en) | 2018-10-30 | 2023-08-22 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
EP4013499A1 (en) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60130910T2 (de) * | 2000-04-17 | 2008-07-10 | Ucb Pharma, S.A. | Enamin-derivate als zell-adhäsionsmoleküle |
SI1370531T1 (sl) * | 2001-02-22 | 2007-08-31 | Ucb Pharma Sa | Derivati fenilalanin enamida s ciklobutensko skupino, za uporabo kot integrin inhibitorji |
-
2002
- 2002-07-17 GB GBGB0216568.6A patent/GB0216568D0/en not_active Ceased
-
2003
- 2003-07-16 PE PE2003000713A patent/PE20040669A1/es not_active Application Discontinuation
- 2003-07-16 JP JP2004520901A patent/JP2005536504A/ja not_active Abandoned
- 2003-07-16 AU AU2003281162A patent/AU2003281162A1/en not_active Abandoned
- 2003-07-16 WO PCT/GB2003/003100 patent/WO2004006918A1/en not_active Application Discontinuation
- 2003-07-16 US US10/620,533 patent/US6872719B1/en not_active Expired - Fee Related
- 2003-07-16 EP EP03740813A patent/EP1524980A1/en not_active Withdrawn
- 2003-07-16 TW TW092119407A patent/TW200404782A/zh unknown
- 2003-07-16 CA CA002492381A patent/CA2492381A1/en not_active Abandoned
- 2003-07-16 AR AR20030102550A patent/AR040579A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2005536504A (ja) | 2005-12-02 |
WO2004006918A1 (en) | 2004-01-22 |
EP1524980A1 (en) | 2005-04-27 |
US6872719B1 (en) | 2005-03-29 |
TW200404782A (en) | 2004-04-01 |
AU2003281162A1 (en) | 2004-02-02 |
GB0216568D0 (en) | 2002-08-28 |
AR040579A1 (es) | 2005-04-13 |
CA2492381A1 (en) | 2004-01-22 |
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Legal Events
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