PE20040761A1 - Compuestos de pirrolotriazona - Google Patents
Compuestos de pirrolotriazonaInfo
- Publication number
- PE20040761A1 PE20040761A1 PE2003000494A PE2003000494A PE20040761A1 PE 20040761 A1 PE20040761 A1 PE 20040761A1 PE 2003000494 A PE2003000494 A PE 2003000494A PE 2003000494 A PE2003000494 A PE 2003000494A PE 20040761 A1 PE20040761 A1 PE 20040761A1
- Authority
- PE
- Peru
- Prior art keywords
- triazin
- aminopropyl
- oxo
- alkenyl
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, SUS ENANTIOMEROS, DIASTEREOMEROS, SALES, PROFARMACOS Y SOLVATOS, DONDE Y1, Y2, Y3 SON CADA UNO H, HALOGENO, -CN, ALQUILO, ENTRE OTROS; Z ES O, S; R1 ES H, ALQUENILO, ALQUINILO, ARILO, ENTRE OTROS; R2 Y R3 SON CADA UNO H, HALOGENO, CICLOALQUILO, ALQUENILO, ALQUINILO, O TOMADOS JUNTOS SON UN ANILLO CARBOCICLICO O HETEROCICLICO DE 3 A 8 ATOMOS; n ES 0-4; A ES O, S O N, Y CUANDO A SEA O O S: R5 NO EXISTA; R4 Y R5 SON CADA UNO H, ALQUENILO, CICLOALQUILO, HETEROARILO, ARALQUILO. SON COMPUESTOS PREFERIDOS: SAL DE ACIDO TRIFLUOROACETICO DE (+-)-N-(3-AMINOPROPIL)-N-[1-(3-BENCIL-4-OXO-3,4-DIHIDROPIRROLO[2,1-f][1,2,4]-TRIAZIN-2-IL)-PROPIL]-4-METILBENZAMIDA; SAL DE ACIDO TRIFLUOROACETICO (+-)-N-(3-AMINOPROPIL)-N-[1-(3-BENCIL-5-CLORO-4-OXO-3,4-DIHIDROPIRROLO[2,1-f][1,2,4]-TRIAZIN-2-IL)-PROPIL]-4-METILBENZAMIDA Y SAL DE ACIDO TRIFLUOROACETICO (+-)-N-(3-AMINOPROPIL)-N-[1-(3-BENCIL-4-OXO-3,4-DIHIDRO-PIRROLO[2,1-f][1,2,4]-TRIAZIN-2-IL)-PROPIL]-4-CLORO-BENZAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS COMO CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38219702P | 2002-05-21 | 2002-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040761A1 true PE20040761A1 (es) | 2004-11-20 |
Family
ID=29584372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000494A PE20040761A1 (es) | 2002-05-21 | 2003-05-21 | Compuestos de pirrolotriazona |
Country Status (7)
Country | Link |
---|---|
US (1) | US7030118B2 (es) |
EP (1) | EP1519729A1 (es) |
AR (1) | AR040081A1 (es) |
AU (1) | AU2003239568A1 (es) |
PE (1) | PE20040761A1 (es) |
TW (1) | TW200407143A (es) |
WO (1) | WO2003099286A1 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
CA2468266A1 (en) | 2001-12-06 | 2003-06-19 | Merck & Co., Inc. | Substituted bicyclic pyrimidinones as a mitotic kinesin ksp inhibitors |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
US7102001B2 (en) * | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
MY145634A (en) | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
US7064203B2 (en) | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
US7102002B2 (en) * | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7102003B2 (en) * | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
US7504521B2 (en) | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
PE20060421A1 (es) | 2004-08-12 | 2006-06-01 | Bristol Myers Squibb Co | Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa |
CA2575188A1 (en) | 2004-08-18 | 2006-02-23 | Astrazeneca Ab | Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer |
US7151176B2 (en) * | 2004-10-21 | 2006-12-19 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
US8875040B2 (en) * | 2005-06-07 | 2014-10-28 | Rockwell Automation Technologies, Inc. | Universal web-based reprogramming method and system |
JP2008524331A (ja) * | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
US7232901B2 (en) | 2005-07-01 | 2007-06-19 | Bristol-Myers Squibb Company | Intermediates useful in preparing certain pyrrolotriazine compounds and process for making such intermediates |
PT1942898E (pt) | 2005-09-14 | 2011-12-20 | Takeda Pharmaceutical | Inibidores da dipeptidilpeptidase para o tratamento da diabetes |
JP5122462B2 (ja) | 2005-09-16 | 2013-01-16 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
US7514435B2 (en) * | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US8063208B2 (en) | 2006-02-16 | 2011-11-22 | Bristol-Myers Squibb Company | Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
TW200902019A (en) | 2007-04-26 | 2009-01-16 | Ono Pharmaceutical Co | Dicyclic heterocyclic compound |
EP2070932A1 (en) * | 2007-12-13 | 2009-06-17 | 4Sc Ag | Pyrazolotriazines |
EP2376491B1 (en) | 2008-12-19 | 2015-03-04 | Cephalon, Inc. | Pyrrolotriazines as alk and jak2 inhibitors |
ME03782B (me) | 2011-04-08 | 2021-04-20 | Janssen Sciences Ireland Unlimited Co | Derivati pirimidina za tretman virusnih infekcija |
EP2518070A1 (en) | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
CN107011346B (zh) | 2011-11-09 | 2020-06-16 | 爱尔兰詹森科学公司 | 用于治疗病毒感染的嘌呤衍生物 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
BR112015000615B1 (pt) | 2012-07-13 | 2022-05-31 | Janssen Sciences Ireland Uc | Purinas macrocíclicas para o tratamento de infecções virais e composição farmacêutica que as compreende |
WO2014015523A1 (en) * | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
CN104837840B (zh) | 2012-10-10 | 2017-08-08 | 爱尔兰詹森科学公司 | 用于治疗病毒感染及其他疾病的吡咯并[3,2‑d]嘧啶衍生物 |
WO2014060432A1 (en) * | 2012-10-16 | 2014-04-24 | Almirall, S.A. | Pyrrolotriazinone derivatives as pi3k inhibitors |
AU2013346793B2 (en) | 2012-11-16 | 2018-03-08 | Janssen Sciences Ireland Uc | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
KR102300861B1 (ko) | 2013-02-21 | 2021-09-10 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체 |
JP6336036B2 (ja) | 2013-03-29 | 2018-06-06 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染治療のための大環状デアザプリノン |
JP6377139B2 (ja) | 2013-05-24 | 2018-08-22 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染症およびさらなる疾患の処置のためのピリドン誘導体 |
PL3030563T3 (pl) | 2013-06-27 | 2018-01-31 | Janssen Sciences Ireland Uc | Pochodne pirolo [3,2-d] pirymidyny do leczenia zakażeń wirusowych i innych chorób |
MX368625B (es) | 2013-07-30 | 2019-10-08 | Janssen Sciences Ireland Uc | Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales. |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EA201690713A1 (ru) | 2013-10-04 | 2016-08-31 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
CA2943075C (en) | 2014-03-19 | 2023-02-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
NZ740616A (en) | 2015-09-14 | 2023-05-26 | Infinity Pharmaceuticals Inc | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
JP6896715B2 (ja) | 2015-09-30 | 2021-06-30 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ヴィッセンシャフテン エーファウ −ジェネラルフェルヴァルトゥング | セピアプテリン還元酵素としてのヘテロアリール誘導体 |
CA3001728A1 (en) | 2015-11-16 | 2017-05-26 | Topadur Pharma Ag | 2-phenyl-3,4-dihydropyrrolo[2,1 -f] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2018002319A1 (en) | 2016-07-01 | 2018-01-04 | Janssen Sciences Ireland Uc | Dihydropyranopyrimidines for the treatment of viral infections |
ES2912945T3 (es) | 2016-09-29 | 2022-05-30 | Janssen Sciences Ireland Unlimited Co | Profármacos de pirimidina para el tratamiento de infecciones virales y otras enfermedades |
TW201945003A (zh) | 2018-03-01 | 2019-12-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | 2,4-二胺基喹唑啉衍生物及其醫學用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6518269B1 (en) * | 2000-07-28 | 2003-02-11 | University Of Arizona Foundation | Cancer treatment |
US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
-
2003
- 2003-05-15 TW TW092113248A patent/TW200407143A/zh unknown
- 2003-05-20 US US10/441,848 patent/US7030118B2/en not_active Expired - Lifetime
- 2003-05-20 EP EP03734129A patent/EP1519729A1/en not_active Withdrawn
- 2003-05-20 AU AU2003239568A patent/AU2003239568A1/en not_active Abandoned
- 2003-05-20 WO PCT/US2003/016179 patent/WO2003099286A1/en not_active Application Discontinuation
- 2003-05-20 AR ARP030101747A patent/AR040081A1/es not_active Application Discontinuation
- 2003-05-21 PE PE2003000494A patent/PE20040761A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2003099286A1 (en) | 2003-12-04 |
TW200407143A (en) | 2004-05-16 |
US7030118B2 (en) | 2006-04-18 |
EP1519729A1 (en) | 2005-04-06 |
AU2003239568A1 (en) | 2003-12-12 |
AR040081A1 (es) | 2005-03-16 |
US20030232832A1 (en) | 2003-12-18 |
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Legal Events
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FC | Refusal |