PE20040582A1 - Inhibidores de vasopeptidasa - Google Patents

Inhibidores de vasopeptidasa

Info

Publication number
PE20040582A1
PE20040582A1 PE2003000623A PE2003000623A PE20040582A1 PE 20040582 A1 PE20040582 A1 PE 20040582A1 PE 2003000623 A PE2003000623 A PE 2003000623A PE 2003000623 A PE2003000623 A PE 2003000623A PE 20040582 A1 PE20040582 A1 PE 20040582A1
Authority
PE
Peru
Prior art keywords
vasopeptidase inhibitors
aryl
alkyl
diabetic
vasopeptidase
Prior art date
Application number
PE2003000623A
Other languages
English (en)
Inventor
Markus Bleich
Stefan Schafer
Wolfgang Linz
Jochen Huber
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20040582A1 publication Critical patent/PE20040582A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE A ES H, ALQUILO C1-C8, CH2OCH2CH2OCH3, -(ALQUIL C1-C4)-ARILO; R1 ES H, -CH2OC(O)C(CH3)3, ACILO; R2 ES H, -CH2-C(O)C(CH3)3, ALQUILO C1-C4, ARILO, ENTRE OTROS; X ES -(CH2)n, -S-, -O-, ENTRE OTROS; n ES 0-1; B1 Y B2 SON CADA UNO H, HIDROXI, ARILO, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE VASOPEPTIDASA UTILES EN EL TRATAMIENTO Y PROFILAXIS DE NEFROPATIAS EN PACIENTES DIABETICOS O NO DIABETICOS
PE2003000623A 2002-06-28 2003-06-20 Inhibidores de vasopeptidasa PE20040582A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2002129180 DE10229180A1 (de) 2002-06-28 2002-06-28 Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen

Publications (1)

Publication Number Publication Date
PE20040582A1 true PE20040582A1 (es) 2004-10-18

Family

ID=29795983

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000623A PE20040582A1 (es) 2002-06-28 2003-06-20 Inhibidores de vasopeptidasa

Country Status (39)

Country Link
US (2) US6930103B2 (es)
EP (1) EP1519732B1 (es)
JP (1) JP4564354B2 (es)
KR (1) KR101072235B1 (es)
CN (1) CN100366254C (es)
AR (1) AR040343A1 (es)
AT (1) ATE548040T1 (es)
AU (1) AU2003280440B2 (es)
BR (1) BR0312250A (es)
CA (1) CA2490277C (es)
CR (1) CR7667A (es)
CY (1) CY1112905T1 (es)
DE (1) DE10229180A1 (es)
DK (1) DK1519732T3 (es)
EC (1) ECSP045513A (es)
ES (1) ES2383889T3 (es)
HK (1) HK1079435A1 (es)
HN (1) HN2003000193A (es)
HR (1) HRP20041212B1 (es)
IL (2) IL165935A0 (es)
MA (1) MA27281A1 (es)
MX (1) MXPA04012230A (es)
NO (1) NO334811B1 (es)
NZ (1) NZ537480A (es)
OA (1) OA12871A (es)
PA (1) PA8576501A1 (es)
PE (1) PE20040582A1 (es)
PL (1) PL218070B1 (es)
PT (1) PT1519732E (es)
RS (1) RS52478B (es)
RU (1) RU2336080C2 (es)
SI (1) SI1519732T1 (es)
SV (1) SV2004001560A (es)
TN (1) TNSN04262A1 (es)
TW (1) TWI326215B (es)
UA (1) UA82845C2 (es)
UY (1) UY27869A1 (es)
WO (1) WO2004002492A1 (es)
ZA (1) ZA200409382B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2482546C2 (ru) * 2011-04-28 2013-05-20 Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" Способ коррекции эндотелиальной дисфункции раствором гомеопатических разведений антител к с-концевому фрагменту рецептора ангиотензина ii

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
ATE138645T1 (de) * 1991-03-01 1996-06-15 Zeria Pharm Co Ltd Indan-derivate als thromboxan-antagonisten
CA2078758C (en) * 1991-09-27 2003-12-09 Alan M. Warshawsky 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
KR100276029B1 (ko) * 1992-02-14 2000-12-15 슈테펜엘.네스비트 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
CN1144487A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺衍生物
AU716519B2 (en) * 1995-06-30 2000-02-24 Laboratoires Merck Sharp & Dohme - Chibret Snc Method of treating renal disease using an ace inhibitor and an A II antagonist
EP0881218B1 (en) 1995-12-27 2003-10-22 Mitsubishi Pharma Corporation Preventives/remedies for complications of diabetes
DE60022525T2 (de) * 1999-08-30 2006-06-14 Sanofi Aventis Deutschland Ramipril zur vorbeugung von kardiovaskulären vorfällen
US6149915A (en) 1999-09-29 2000-11-21 Shiva Biomedical, Llc Treatment of diabetic nephropathy and microalbuminuria
IL158289A0 (en) * 2001-04-12 2004-05-12 Aventis Pharma Gmbh Mercaptoacetylamide derivatives, a process for their preparation and their use
WO2003013434A2 (en) * 2001-08-06 2003-02-20 Genomed, Llc Methods and compositions for treating diseases associated with excesses in ace

Also Published As

Publication number Publication date
DE10229180A1 (de) 2004-01-29
IL165935A (en) 2010-12-30
PL218070B1 (pl) 2014-10-31
HRP20041212B1 (hr) 2013-06-30
US6930103B2 (en) 2005-08-16
KR20050013642A (ko) 2005-02-04
BR0312250A (pt) 2005-04-26
CY1112905T1 (el) 2016-04-13
US20050171090A1 (en) 2005-08-04
ATE548040T1 (de) 2012-03-15
EP1519732B1 (en) 2012-03-07
ECSP045513A (es) 2005-03-10
DK1519732T3 (da) 2012-06-18
JP4564354B2 (ja) 2010-10-20
EP1519732A1 (en) 2005-04-06
CA2490277C (en) 2011-11-01
ZA200409382B (en) 2006-01-25
US7514423B2 (en) 2009-04-07
KR101072235B1 (ko) 2011-10-12
AR040343A1 (es) 2005-03-30
AU2003280440A1 (en) 2004-01-19
CN1665512A (zh) 2005-09-07
CA2490277A1 (en) 2004-01-08
RU2005102087A (ru) 2005-07-10
UY27869A1 (es) 2003-12-31
UA82845C2 (en) 2008-05-26
AU2003280440B2 (en) 2009-07-16
RS52478B (en) 2013-02-28
SV2004001560A (es) 2004-02-26
HK1079435A1 (en) 2006-04-07
SI1519732T1 (sl) 2012-05-31
MA27281A1 (fr) 2005-04-01
ES2383889T3 (es) 2012-06-27
NZ537480A (en) 2005-11-25
TNSN04262A1 (en) 2007-03-12
NO20050425L (no) 2005-01-25
PT1519732E (pt) 2012-05-22
WO2004002492A1 (en) 2004-01-08
PL372992A1 (en) 2005-08-08
IL165935A0 (en) 2006-01-15
TWI326215B (en) 2010-06-21
MXPA04012230A (es) 2005-02-25
HRP20041212A2 (en) 2005-06-30
CN100366254C (zh) 2008-02-06
PA8576501A1 (es) 2004-02-07
JP2005533815A (ja) 2005-11-10
NO334811B1 (no) 2014-06-02
US20040058911A1 (en) 2004-03-25
RS100704A (en) 2007-02-05
RU2336080C2 (ru) 2008-10-20
HN2003000193A (es) 2004-10-27
TW200406214A (en) 2004-05-01
OA12871A (en) 2006-09-15
CR7667A (es) 2005-06-16

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