PE20030819A1 - 2'halo-3',5'-dialcoxi-fen-1'-il-imino-2-imidazolidinas - Google Patents

2'halo-3',5'-dialcoxi-fen-1'-il-imino-2-imidazolidinas

Info

Publication number
PE20030819A1
PE20030819A1 PE2003000103A PE2003000103A PE20030819A1 PE 20030819 A1 PE20030819 A1 PE 20030819A1 PE 2003000103 A PE2003000103 A PE 2003000103A PE 2003000103 A PE2003000103 A PE 2003000103A PE 20030819 A1 PE20030819 A1 PE 20030819A1
Authority
PE
Peru
Prior art keywords
fen
imino
imidazolidine
dialcoxy
imidazolidines
Prior art date
Application number
PE2003000103A
Other languages
English (en)
Inventor
Franz Esser
Naoki Ishiguro
Pascale Pouzet
Ikunobu Muramatsu
Hisato Kitagawa
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20030819A1 publication Critical patent/PE20030819A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A 2'-HALO-3',5'-DIALCOXI-FEN-1'-IL-IMINO-2-IMIDAZOLIDINAS DE FORMULA I DONDE R ES F, Cl, Br, CF3, CH2F, CHF2; R1 Y R2 SON ALQUILO. SON COMPUESTOS PREFERIDOS 2'-CLORO-3,5'-DIMETOXI-FEN-1'-IL-IMINO-2-IMIDAZOLIDINA; 2'-CLORO-3,5'-DIETOXI-FEN-1'-IL-IMINO-2-IMIDAZOLIDINA; 2'-CLORO-3,5'-DIPROPILOXI-FEN-1'-IL-IMINO-2-IMIDAZOLIDINA; 2'-BROMO-3,5'-DIMETOXI-FEN-1'-IL-IMINO-2-IMIDAZOLIDINA; 2'-BROMO-3,5'-DIETOXI-FEN-1'-IL-IMINO-2-IMIDAZOLIDINA; 2'-BROMO-3,5'-DIPROPILOXI-FEN-1'-IL-IMINO-2-IMIDAZOLIDINA. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE DE 0,001mg A 1g DEL COMPUESTO. EL COMPUESTO TIENE UN EFECTO AGONISTA SOBRE RECEPTORES DE ALFA 1L Y PUEDE SER UTIL PARA EL TRATAMIENTO DE INCONTINENCIA URINARIA
PE2003000103A 2002-01-31 2003-01-30 2'halo-3',5'-dialcoxi-fen-1'-il-imino-2-imidazolidinas PE20030819A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02002352A EP1333028A1 (en) 2002-01-31 2002-01-31 2'-Halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine derivatives and the use thereof for the treatment of urinary incontinence

Publications (1)

Publication Number Publication Date
PE20030819A1 true PE20030819A1 (es) 2003-10-20

Family

ID=8185397

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000103A PE20030819A1 (es) 2002-01-31 2003-01-30 2'halo-3',5'-dialcoxi-fen-1'-il-imino-2-imidazolidinas

Country Status (20)

Country Link
EP (2) EP1333028A1 (es)
JP (1) JP2005516066A (es)
KR (1) KR20040074134A (es)
CN (1) CN1617857A (es)
AR (1) AR038380A1 (es)
BR (1) BR0215560A (es)
CA (1) CA2474588A1 (es)
EA (1) EA200400877A1 (es)
EC (1) ECSP045210A (es)
HR (1) HRP20040691A2 (es)
HU (1) HUP0402654A2 (es)
IL (1) IL162776A0 (es)
MX (1) MXPA04007250A (es)
NO (1) NO20043614L (es)
PE (1) PE20030819A1 (es)
PL (1) PL369826A1 (es)
TW (1) TW200418462A (es)
UY (1) UY27628A1 (es)
WO (1) WO2003064398A1 (es)
ZA (1) ZA200405173B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4168086B1 (ja) * 2008-04-16 2008-10-22 国立大学法人福井大学 イミダゾリン誘導体
WO2009140137A1 (en) * 2008-05-13 2009-11-19 Allergan, Inc. Naphthylmethylimidizoles for the treatment of stress urinary incontinence
WO2009140138A1 (en) * 2008-05-13 2009-11-19 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
US8063231B2 (en) * 2008-06-09 2011-11-22 Allergan, Inc. Methods of treating alpha adrenergic mediated conditions
DK2932968T3 (en) * 2008-06-09 2018-03-12 Allergan Inc CONNECTION TO TREATMENT OF ALFA-ADRENERG MEDIED CONDITIONS
US9034910B2 (en) 2008-06-09 2015-05-19 Allergan, Inc. Methods of treating alpha adrenergic mediated conditions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2220906A1 (de) * 1972-04-28 1973-11-15 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2259160A1 (de) * 1972-12-02 1974-06-06 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline, deren saeureadditionssalze und verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel
AT333749B (de) * 1974-07-03 1976-12-10 Chemie Linz Ag Verfahren zur herstellung von neuen 2-arylamino-2-imidazolinderivaten
MTP837B (en) * 1977-11-07 1979-10-22 Hoffman La Roche And Co Aktien Derivatives 2 finino-imidazolidire
DE3514351A1 (de) * 1985-04-20 1986-11-06 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte 2-(n-alkinyl-n-phenyl)amino)-imidazolinderivate, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives
DE19740176C2 (de) * 1997-09-12 2000-04-06 Lemfoerder Metallwaren Ag Handschaltvorrichtung für ein Kraftfahrzeug

Also Published As

Publication number Publication date
UY27628A1 (es) 2003-08-29
AR038380A1 (es) 2005-01-12
MXPA04007250A (es) 2004-10-29
EP1333028A1 (en) 2003-08-06
ECSP045210A (es) 2004-09-28
WO2003064398A1 (en) 2003-08-07
NO20043614L (no) 2004-08-30
ZA200405173B (en) 2005-06-21
EP1472231A1 (en) 2004-11-03
IL162776A0 (en) 2005-11-20
EA200400877A1 (ru) 2005-02-24
JP2005516066A (ja) 2005-06-02
TW200418462A (en) 2004-10-01
CA2474588A1 (en) 2003-08-07
KR20040074134A (ko) 2004-08-21
HRP20040691A2 (en) 2004-12-31
BR0215560A (pt) 2004-12-21
HUP0402654A2 (hu) 2005-03-29
PL369826A1 (en) 2005-05-02
CN1617857A (zh) 2005-05-18

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