PE20020904A1 - Derivados de imidazolidina como inhibidores de la adhesion y migracion de leucocitos - Google Patents

Derivados de imidazolidina como inhibidores de la adhesion y migracion de leucocitos

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Publication number
PE20020904A1
PE20020904A1 PE2002000184A PE2002000184A PE20020904A1 PE 20020904 A1 PE20020904 A1 PE 20020904A1 PE 2002000184 A PE2002000184 A PE 2002000184A PE 2002000184 A PE2002000184 A PE 2002000184A PE 20020904 A1 PE20020904 A1 PE 20020904A1
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PE
Peru
Prior art keywords
adhesion
leukocytes
migration
inhibitors
phenyl
Prior art date
Application number
PE2002000184A
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English (en)
Inventor
Horst Blum
Volkmar Wehner
Hans Ulrich Stilz
Hartmut Ruetten
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Aventis Pharma Gmbh
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Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PE20020904A1 publication Critical patent/PE20020904A1/es

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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/74Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • A61P19/00Drugs for skeletal disorders
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P35/00Antineoplastic agents
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    • A61P35/00Antineoplastic agents
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78Radicals substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
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  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A DERIVADOS DE IMIDAZOLIDINA DE FORMULA I DONDE A ES CICLOPROPILMETILO O ISOBUTILO; E ES -CO-R6, -CO-H, CH2-O-R7; Z ES O, S; R1 ES H, METILO; R2 ES FENILO, PIRIDILO, ALQUILO C1-C4 CON F, FENILO, ENTRE OTROS; R3 Y R4 SON METILO, TRIFLUOROMETILO; R5 ES H, ALQUILO C1-C4, DONDE EL RESTO ALQUILO PUEDE ESTAR SUSTITUIDO; R6 ES OH, ALCOXI C1-C10, FENIL-ALCOXI C1-C8, FENILOXI, ALQUIL C1-C8, ENTRE OTROS; R7 ES H, ALQUILO C1-C4. UN COMPUESTO PREFERIDO ES ACIDO (R)-3-((S)-2-(4,4-DIMETIL-3-(4-(3-(2-METILFENIL)UREIDO)-3-METOXIBENCIL)-2,5-DIOXOIMIDAZOLIDIN-1-IL)-2-(CICLOPROPILMETIL)ACETILAMINO)-3-METILPROPIONICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS DE FORMULA I SON INHIBIDORES DE LA ADHESION Y MIGRACION DE LEUCOCITOS Y/O ANTAGONISTAS DEL RECEPTOR DE ADHESION VLA-4 QUE PERTENECE AL GRUPO DE LAS INTEGRINAS
PE2002000184A 2001-03-10 2002-03-08 Derivados de imidazolidina como inhibidores de la adhesion y migracion de leucocitos PE20020904A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10111877A DE10111877A1 (de) 2001-03-10 2001-03-10 Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate

Publications (1)

Publication Number Publication Date
PE20020904A1 true PE20020904A1 (es) 2002-12-10

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ID=7677184

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Application Number Title Priority Date Filing Date
PE2002000184A PE20020904A1 (es) 2001-03-10 2002-03-08 Derivados de imidazolidina como inhibidores de la adhesion y migracion de leucocitos

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US (1) US6680333B2 (es)
EP (1) EP1373249B1 (es)
JP (1) JP4482277B2 (es)
KR (1) KR100991678B1 (es)
CN (1) CN1227248C (es)
AR (1) AR035692A1 (es)
AT (1) ATE293621T1 (es)
AU (1) AU2002233358B2 (es)
BG (1) BG108134A (es)
BR (1) BR0207981A (es)
CA (1) CA2440648C (es)
CZ (1) CZ301893B6 (es)
DE (2) DE10111877A1 (es)
DK (1) DK1373249T3 (es)
EE (1) EE05401B1 (es)
ES (1) ES2240687T3 (es)
HK (1) HK1062173A1 (es)
HR (1) HRP20030713B1 (es)
HU (1) HU228304B1 (es)
IL (2) IL157830A0 (es)
ME (1) MEP61108A (es)
MX (1) MXPA03007634A (es)
MY (1) MY129029A (es)
NO (1) NO326001B1 (es)
NZ (1) NZ528075A (es)
PE (1) PE20020904A1 (es)
PL (1) PL204622B1 (es)
PT (1) PT1373249E (es)
RS (1) RS51140B (es)
RU (1) RU2303592C2 (es)
SI (1) SI1373249T1 (es)
SK (1) SK286652B6 (es)
TW (1) TWI328587B (es)
WO (1) WO2002072573A1 (es)
ZA (1) ZA200306107B (es)

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DK1373249T3 (da) 2005-08-22
HUP0303455A2 (hu) 2004-03-01
ATE293621T1 (de) 2005-05-15
TWI328587B (en) 2010-08-11
PL204622B1 (pl) 2010-01-29
KR20030082980A (ko) 2003-10-23
HU228304B1 (en) 2013-03-28
KR100991678B1 (ko) 2010-11-04
HRP20030713B1 (en) 2006-02-28
HRP20030713A2 (en) 2005-02-28
PL362573A1 (en) 2004-11-02
RU2003129986A (ru) 2005-03-20
HK1062173A1 (en) 2004-10-21
AU2002233358B2 (en) 2007-03-22
IL157830A (en) 2009-05-04
RS51140B (sr) 2010-10-31
HUP0303455A3 (en) 2005-06-28
CN1227248C (zh) 2005-11-16
SK286652B6 (sk) 2009-03-05
BG108134A (bg) 2004-09-30
WO2002072573A1 (en) 2002-09-19
DE60203791D1 (de) 2005-05-25
PT1373249E (pt) 2005-07-29
JP2004523574A (ja) 2004-08-05
EP1373249A1 (en) 2004-01-02
NO20033981D0 (no) 2003-09-09
MXPA03007634A (es) 2003-12-04
YU70803A (sh) 2006-05-25
EP1373249B1 (en) 2005-04-20
US20030073723A1 (en) 2003-04-17
NO326001B1 (no) 2008-09-01
ZA200306107B (en) 2004-09-01
JP4482277B2 (ja) 2010-06-16
NO20033981L (no) 2003-09-09
CN1496360A (zh) 2004-05-12
MY129029A (en) 2007-03-30
DE60203791T2 (de) 2006-01-19
CA2440648C (en) 2010-06-15
MEP61108A (en) 2011-05-10
SI1373249T1 (es) 2005-08-31
BR0207981A (pt) 2004-06-15
DE10111877A1 (de) 2002-09-12
ES2240687T3 (es) 2005-10-16
NZ528075A (en) 2005-02-25
CZ301893B6 (cs) 2010-07-21
CZ20032429A3 (cs) 2003-12-17
EE05401B1 (et) 2011-04-15
SK11262003A3 (sk) 2004-01-08
RU2303592C2 (ru) 2007-07-27
EE200300436A (et) 2003-12-15
AR035692A1 (es) 2004-06-23
US6680333B2 (en) 2004-01-20
IL157830A0 (en) 2004-03-28
CA2440648A1 (en) 2002-09-19

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