DK190284A - Dopamin-beta-hydroxylase-inhibitorer - Google Patents
Dopamin-beta-hydroxylase-inhibitorer Download PDFInfo
- Publication number
- DK190284A DK190284A DK190284A DK190284A DK190284A DK 190284 A DK190284 A DK 190284A DK 190284 A DK190284 A DK 190284A DK 190284 A DK190284 A DK 190284A DK 190284 A DK190284 A DK 190284A
- Authority
- DK
- Denmark
- Prior art keywords
- dopamine
- beta
- hydroxylase inhibitors
- 4alkyl
- och3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Description
R^ er -H, phenyl eller benzyl, og n er 0-4, eller et farmaceutisk acceptabelt syreadditionssalt eller hydrat deraf, forudsat at når R er -C02H eller -CH2NHCgH5, X er -H, og n er 1, er Y ikke -H, kan anvendes til at inhi-bere DBH-aktivitet i pattedyr.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48412383 | 1983-04-12 | ||
US06/484,123 US4532331A (en) | 1983-04-12 | 1983-04-12 | 1-Benzyl-2-aminomethyl imidazole derivatives |
Publications (4)
Publication Number | Publication Date |
---|---|
DK190284D0 DK190284D0 (da) | 1984-04-12 |
DK190284A true DK190284A (da) | 1984-10-13 |
DK162629B DK162629B (da) | 1991-11-25 |
DK162629C DK162629C (da) | 1992-04-13 |
Family
ID=23922842
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK190284A DK162629C (da) | 1983-04-12 | 1984-04-12 | 2-substituerede 1-aralkyl-imidazoler og farmaceutiske midler der indeholder disse, anvendelse heraf til fremstilling af farmaceutiske midler samt fremgangsmaade til fremstilling heraf |
DK099791A DK99791A (da) | 1983-04-12 | 1991-05-24 | Aralkylimidazol |
DK099691A DK99691A (da) | 1983-04-12 | 1991-05-24 | Dopamin-beta-hydroxylase-inhibitorer og fremgangsmaade til deres fremstilling |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK099791A DK99791A (da) | 1983-04-12 | 1991-05-24 | Aralkylimidazol |
DK099691A DK99691A (da) | 1983-04-12 | 1991-05-24 | Dopamin-beta-hydroxylase-inhibitorer og fremgangsmaade til deres fremstilling |
Country Status (12)
Country | Link |
---|---|
US (1) | US4532331A (da) |
EP (1) | EP0125783B1 (da) |
JP (1) | JPS59199678A (da) |
AT (1) | ATE39686T1 (da) |
AU (1) | AU575558B2 (da) |
CA (1) | CA1223598A (da) |
DE (1) | DE3475905D1 (da) |
DK (3) | DK162629C (da) |
ES (2) | ES531552A0 (da) |
GR (2) | GR79885B (da) |
IE (1) | IE57234B1 (da) |
PT (1) | PT78389B (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
US4992459A (en) * | 1983-04-12 | 1991-02-12 | Smithkline Beecham Corporation | Dopamine-β-hydroxylase inhibitors |
EP0149976A3 (de) * | 1983-12-30 | 1986-12-10 | Ciba-Geigy Ag | Substituierte Imidazole |
JPS61110266A (ja) * | 1984-11-05 | 1986-05-28 | Omron Tateisi Electronics Co | カード発行方法 |
US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
US4719223A (en) * | 1985-10-31 | 1988-01-12 | Smithkline Beckman Corporation | Imidazolethiol dopamine-beta-hydroxylase inhibitors |
US4743613A (en) * | 1986-04-08 | 1988-05-10 | Smithkline Beckman Corporation | Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity |
JP2581556B2 (ja) * | 1986-05-06 | 1997-02-12 | メレルダウファーマスーティカルズ インコーポレーテッド | 新規なドパミンベ−タヒドロキシラ−ゼ抑制剤 |
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
NZ221427A (en) * | 1986-08-18 | 1990-12-21 | Smithkline Beckman Corp | 2-mercaptoimidazole derivatives and pharmaceutical compositions |
US4761415A (en) * | 1986-08-28 | 1988-08-02 | Smithkline Beckman Corporation | Dopamine-β-hydroxylase inhibitors |
US4996221A (en) * | 1987-01-13 | 1991-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Histamine derivatives as immune modulators |
US4762850A (en) * | 1987-03-24 | 1988-08-09 | Smithkline Beckman Corporation | Dopamine-beta-hydroxylase inhibitors |
US4859779A (en) * | 1987-03-24 | 1989-08-22 | Smithkline Beckman Corporation | Dopamine-β-hydroxylase inhibitors |
US4835154A (en) * | 1987-06-01 | 1989-05-30 | Smithkline Beckman Corporation | 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors |
US4839371A (en) * | 1987-09-17 | 1989-06-13 | Smithkline Beckman Corporation | 3-aralkyl-2-mercaptoyridines as dopamine-β-hydroxylase inhibitors |
US4882348A (en) * | 1987-12-29 | 1989-11-21 | Smithkline Beckman Corporation | 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors |
US4935438A (en) * | 1987-12-29 | 1990-06-19 | Smithkline Beckman Corporation | Dopamine-β-hydroxylase inhibitors |
US4876266A (en) * | 1987-12-31 | 1989-10-24 | Smithkline Beckman Corporation | 1-aralkyl-2-mercaptoimidazolines as DBH inhibitors |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
DK440989A (da) * | 1988-09-12 | 1990-03-13 | Smithkline Beecham Corp | Dopamin-beta-hydroxylase inhibitorer |
US5354867A (en) * | 1988-12-06 | 1994-10-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
JP2568315B2 (ja) * | 1989-06-30 | 1997-01-08 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 縮合環アリール置換イミダゾール |
CA2032289A1 (en) * | 1989-12-29 | 1991-06-30 | Joseph A. Finkelstein | Substituted 5-(alkyl) carboxamide imidazoles |
GB9010366D0 (en) * | 1990-05-09 | 1990-06-27 | Smith Kline French Lab | Medicaments |
AU3467493A (en) * | 1992-01-27 | 1993-09-01 | Board Of Trustees Of The Leland Stanford Junior University | Histamine derivatives and methods for their use |
US7572921B2 (en) * | 2005-04-05 | 2009-08-11 | Boehringer Ingelheim International Gmbh | Substituted benzylimidazoles useful for the treatment of inflammatory diseases |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE688585A (da) * | 1965-10-21 | 1967-04-20 | ||
BE793407A (fr) * | 1971-12-28 | 1973-06-28 | Hoechst Ag | Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation |
DE2259627A1 (de) * | 1972-12-06 | 1974-06-12 | Hoechst Ag | Imidazolyl-(2)-thio-alkansaeureester und verfahren zu ihrer herstellung |
JPS5069078A (en) * | 1973-01-24 | 1975-06-09 | Yoshitomi Pharmaceutical | Shinkinaimidazoorujudotai no seizoho |
CA1028331A (en) * | 1973-01-24 | 1978-03-21 | Michio Nakanishi | Imidazole compounds |
FI803127L (fi) * | 1979-10-03 | 1981-04-04 | Glaxo Group Ltd | Heterocykliska foereningar |
GB2096987B (en) * | 1981-04-22 | 1984-04-04 | Farmos Oy | Substituted imidazole and imidazole derivatives and their preparation and use |
PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
-
1983
- 1983-04-12 US US06/484,123 patent/US4532331A/en not_active Expired - Fee Related
-
1984
- 1984-04-09 PT PT78389A patent/PT78389B/pt not_active IP Right Cessation
- 1984-04-10 EP EP84302422A patent/EP0125783B1/en not_active Expired
- 1984-04-10 DE DE8484302422T patent/DE3475905D1/de not_active Expired
- 1984-04-10 IE IE875/84A patent/IE57234B1/en unknown
- 1984-04-10 AT AT84302422T patent/ATE39686T1/de active
- 1984-04-11 CA CA000451719A patent/CA1223598A/en not_active Expired
- 1984-04-11 GR GR74382A patent/GR79885B/el unknown
- 1984-04-11 GR GR74375A patent/GR79907B/el unknown
- 1984-04-11 AU AU26722/84A patent/AU575558B2/en not_active Ceased
- 1984-04-12 JP JP59074801A patent/JPS59199678A/ja active Pending
- 1984-04-12 ES ES531552A patent/ES531552A0/es active Granted
- 1984-04-12 DK DK190284A patent/DK162629C/da not_active IP Right Cessation
-
1985
- 1985-01-15 ES ES539565A patent/ES539565A0/es active Granted
-
1991
- 1991-05-24 DK DK099791A patent/DK99791A/da not_active Application Discontinuation
- 1991-05-24 DK DK099691A patent/DK99691A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IE57234B1 (en) | 1992-06-17 |
IE840875L (en) | 1984-10-12 |
GR79885B (da) | 1984-10-31 |
EP0125783A1 (en) | 1984-11-21 |
DE3475905D1 (en) | 1989-02-09 |
US4532331A (en) | 1985-07-30 |
ES8602686A1 (es) | 1985-12-01 |
EP0125783B1 (en) | 1989-01-04 |
DK99791D0 (da) | 1991-05-24 |
PT78389B (en) | 1986-09-15 |
DK99691D0 (da) | 1991-05-24 |
DK99791A (da) | 1991-05-24 |
PT78389A (en) | 1984-05-01 |
DK190284D0 (da) | 1984-04-12 |
ES8601909A1 (es) | 1985-11-01 |
GR79907B (da) | 1984-10-31 |
JPS59199678A (ja) | 1984-11-12 |
ES539565A0 (es) | 1985-11-01 |
ATE39686T1 (de) | 1989-01-15 |
DK99691A (da) | 1991-05-24 |
DK162629B (da) | 1991-11-25 |
CA1223598A (en) | 1987-06-30 |
DK162629C (da) | 1992-04-13 |
AU575558B2 (en) | 1988-08-04 |
AU2672284A (en) | 1984-10-18 |
ES531552A0 (es) | 1985-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |