ES8601911A1 - Un procedimiento para preparar derivados de fenilamino-mer- captoimidazol - Google Patents

Un procedimiento para preparar derivados de fenilamino-mer- captoimidazol

Info

Publication number
ES8601911A1
ES8601911A1 ES539563A ES539563A ES8601911A1 ES 8601911 A1 ES8601911 A1 ES 8601911A1 ES 539563 A ES539563 A ES 539563A ES 539563 A ES539563 A ES 539563A ES 8601911 A1 ES8601911 A1 ES 8601911A1
Authority
ES
Spain
Prior art keywords
4alkyl
so2c1
dopamine
beta
hydroxylase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539563A
Other languages
English (en)
Other versions
ES539563A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES8601911A1 publication Critical patent/ES8601911A1/es
Publication of ES539563A0 publication Critical patent/ES539563A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE FENILAMINO-MERCAPTO-IMIDAZOL, DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES Y DE SUS HIDRATOS, DE FORMULA (I), EN LA QUE Y ES OH; R ES HIDROGENO O ALQUILO C1-4; Y X PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO QUE TIENE LA FORMULA (II), EN LA QUE Y1 ES OCH3 Y X1 TIENE EL MISMO SIGNIFICADO QUE X SALVO OH, CON UN ACIDO, TAL COMO ACIDO BROMHIDRICO, CALENTANDO A REFLUJO BAJO ARGON, CON LO QUE SE PRODUCE LA DESPROTECCION DEL GRUPO METOXI Y LA CICLISACION DEL COMPUESTO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES DIURETICOS, CARDIOTONICOS, ANTIHIPERTENSIVOS Y VASODILATADORES.
ES539563A 1983-04-12 1985-01-15 Un procedimiento para preparar derivados de fenilamino-mer- captoimidazol Granted ES539563A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48412283A 1983-04-12 1983-04-12
US59066584A 1984-03-19 1984-03-19

Publications (2)

Publication Number Publication Date
ES8601911A1 true ES8601911A1 (es) 1985-11-01
ES539563A0 ES539563A0 (es) 1985-11-01

Family

ID=27047873

Family Applications (2)

Application Number Title Priority Date Filing Date
ES531551A Granted ES531551A0 (es) 1983-04-12 1984-04-12 Un procedimiento de preparar un compuesto derivado de fenetilamino-mercapto imidazol, inhibidor de dopamina-beta-hidroxilasa
ES539563A Granted ES539563A0 (es) 1983-04-12 1985-01-15 Un procedimiento para preparar derivados de fenilamino-mer- captoimidazol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES531551A Granted ES531551A0 (es) 1983-04-12 1984-04-12 Un procedimiento de preparar un compuesto derivado de fenetilamino-mercapto imidazol, inhibidor de dopamina-beta-hidroxilasa

Country Status (10)

Country Link
EP (3) EP0308573A3 (es)
AU (2) AU576317B2 (es)
CA (1) CA1242205A (es)
DE (1) DE3483652D1 (es)
DK (2) DK190384A (es)
ES (2) ES531551A0 (es)
GR (1) GR79919B (es)
IE (1) IE57200B1 (es)
MY (1) MY102519A (es)
PT (1) PT78388B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992459A (en) * 1983-04-12 1991-02-12 Smithkline Beecham Corporation Dopamine-β-hydroxylase inhibitors
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
US4707488A (en) * 1985-02-11 1987-11-17 Smithkline Beckman Corporation Dopamine-β-hydroxylase inhibitors and use thereof
US4634711A (en) * 1985-08-02 1987-01-06 Smithkline Beckman Corporation Pyridylalkyl imidazole-2-thiols
US4873357A (en) * 1985-10-31 1989-10-10 Smithkline Beckman Corporation Trifluoro acetyl-cyano-aniline intermediates for dopamine-βhydroxylase inhibitors
US4719223A (en) * 1985-10-31 1988-01-12 Smithkline Beckman Corporation Imidazolethiol dopamine-beta-hydroxylase inhibitors
US4743613A (en) * 1986-04-08 1988-05-10 Smithkline Beckman Corporation Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity
US5057613A (en) * 1986-05-06 1991-10-15 Merrell Dow Pharmaceuticals Novel thione dopamine beta hydroxylase inhibitors
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
IL82542A0 (en) * 1986-05-23 1987-11-30 Smithkline Beckman Corp Triazole derivatives,their preparation and pharmaceutical compositions containing them
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
NZ221427A (en) * 1986-08-18 1990-12-21 Smithkline Beckman Corp 2-mercaptoimidazole derivatives and pharmaceutical compositions
US4762850A (en) * 1987-03-24 1988-08-09 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors
EP0285356A3 (en) * 1987-03-30 1989-05-31 Smithkline Beecham Corporation Dopamine-beta-hydroxylase inhibitors
JP2577222B2 (ja) * 1987-04-10 1997-01-29 興和株式会社 新規な置換アニリド誘導体
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US4798843A (en) * 1987-07-09 1989-01-17 Smithkline Beckman Corporation 2-mercaproimidazole dopamine-β-hydroxylase inhibitors
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
US4935438A (en) * 1987-12-29 1990-06-19 Smithkline Beckman Corporation Dopamine-β-hydroxylase inhibitors
AU3031889A (en) * 1987-12-31 1989-08-01 Smithkline Beckman Corporation 1-aralkyl-1,2-dihydropyrimidine-2-thiones
US4876266A (en) * 1987-12-31 1989-10-24 Smithkline Beckman Corporation 1-aralkyl-2-mercaptoimidazolines as DBH inhibitors
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
CA2002247A1 (en) * 1988-12-01 1990-06-01 Lawrence I. Kruse Dopamine-.beta.-hydroxylase inhibitors
CA2002246A1 (en) * 1988-12-01 1990-06-01 Lawrence I. Kruse Dopamine-.beta.-hydroxylase inhibitors
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
JP2568315B2 (ja) * 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
GB9010366D0 (en) * 1990-05-09 1990-06-27 Smith Kline French Lab Medicaments
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
FR2675503B1 (fr) * 1991-04-19 1994-02-18 Roussel Uclaf Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2664271B1 (fr) * 1990-07-05 1994-02-18 Roussel Uclaf Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE19620408A1 (de) * 1996-05-21 1997-11-27 Bayer Ag Mercapto-imidazolyl-Derivate
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
FR2928544A1 (fr) * 2008-03-17 2009-09-18 Oreal Utilisation d'inhibiteurs de la dopamine-beta hydroxylase pour la pigmentation capillaire.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE825253C (de) * 1948-11-27 1951-12-17 Bayer Ag Verfahren zur Herstellung von unsymmetrischen disubstituierten Thioharnstoffen
DE1695093A1 (de) * 1965-10-21 1970-12-10 Geigy Ag J R Neue Imidazolderivate
GB1291524A (en) * 1969-06-27 1972-10-04 Abbott Lab N-dialkoxyalkyl substituted phenethylamine derivatives
US3767816A (en) * 1971-08-26 1973-10-23 Rohm & Haas Diuretic thioureas
BE788850A (fr) * 1972-09-15 1973-03-15 Hoffmann La Roche Derives d'acide benzoique
DE2259627A1 (de) * 1972-12-06 1974-06-12 Hoechst Ag Imidazolyl-(2)-thio-alkansaeureester und verfahren zu ihrer herstellung
DE2538231A1 (de) * 1975-08-28 1977-03-10 Dynamit Nobel Ag Verfahren zur herstellung von aminoacetaldehydacetalen
CA1147342A (en) * 1977-10-12 1983-05-31 Kazuo Imai Process of producing novel phenylethanolamine derivatives
FI803127L (fi) * 1979-10-03 1981-04-04 Glaxo Group Ltd Heterocykliska foereningar
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors

Also Published As

Publication number Publication date
EP0125033A1 (en) 1984-11-14
GR79919B (es) 1984-10-31
AU613984B2 (en) 1991-08-15
DK190384A (da) 1984-10-13
PT78388B (en) 1986-09-15
MY102519A (en) 1992-07-31
IE57200B1 (en) 1992-06-03
IE840876L (en) 1984-10-12
DE3483652D1 (de) 1991-01-03
AU576317B2 (en) 1988-08-25
PT78388A (en) 1984-05-01
EP0212066A1 (en) 1987-03-04
EP0212066B1 (en) 1990-11-22
AU2585388A (en) 1989-02-23
EP0125033B1 (en) 1989-04-26
DK5891D0 (da) 1991-01-11
AU2672684A (en) 1984-10-18
ES539563A0 (es) 1985-11-01
EP0308573A3 (en) 1990-03-21
DK190384D0 (da) 1984-04-12
DK5891A (da) 1991-01-11
CA1242205A (en) 1988-09-20
ES8506284A1 (es) 1985-07-01
EP0308573A2 (en) 1989-03-29
ES531551A0 (es) 1985-07-01

Similar Documents

Publication Publication Date Title
ES8506284A1 (es) Un procedimiento de preparar un compuesto derivado de fenetilamino-mercapto imidazol, inhibidor de dopamina-beta-hidroxilasa
ES8601909A1 (es) Un procedimiento para preparar derivados de imidazol
EA200001122A1 (ru) Ингибиторы синтазы оксида азота
BG60262B1 (bg) Метод за получаване на заместени двупръстенни съединения
CA1273019C (en) ENKEPHALINASE INHIBITORS
ES519832A0 (es) Un procedimiento para preparar pirazolo (4,3-c)piridinas.
EA199900632A1 (ru) 2-амино-6-(2-замещенные-4-фенокси)-замещенные-пиридины
ES8401960A1 (es) Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
ES496038A0 (es) Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
ATE67193T1 (de) 6-phenyl-pyridazin-verbindungen.
ES495826A0 (es) Procedimiento para la obtencion de acido fosfonohidroxiace- tico
ES8206455A1 (es) Procedimiento para la preparacion de derivados de guanidina
ES8407009A1 (es) Un procedimiento para preparar -15-desoxiespergualina.
ES466239A1 (es) Un procedimiento de preparacion de azacicloalcanos, azaci- cloalquenos y sus derivados
AR220710A1 (es) Nuevos derivados de n-(2-oxoperhidro-3-furil)-anilidas del acido ciclopropanocarboxilico;composiciones fungicidas que contienen estos compuestos,y procedimientos para producirlos
NO852618L (no) Aroyl-substituerte dihydro-1,4-tiaziner.
ES8609322A1 (es) Un procedimiento de obtencion de imidazoquinolinas

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303