PE20020208A1 - Derivados de n-heterociclos condensados como ligandos para receptores de melanocortina - Google Patents
Derivados de n-heterociclos condensados como ligandos para receptores de melanocortinaInfo
- Publication number
- PE20020208A1 PE20020208A1 PE2001000626A PE2001000626A PE20020208A1 PE 20020208 A1 PE20020208 A1 PE 20020208A1 PE 2001000626 A PE2001000626 A PE 2001000626A PE 2001000626 A PE2001000626 A PE 2001000626A PE 20020208 A1 PE20020208 A1 PE 20020208A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitor
- glustes
- ligands
- melanosetment
- cr9r10
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I O UNA MEZCLA DE SUS ESTEREOISOMEROS, DONDE m ES 0-2; HET ES UN RESTO HETEROCICLO TAL COMO EL GRUPO a, GRUPO b, ENTRE OTROS DONDE d ES 0-2; e ES 1-2; Y2 ES O, S; A ES UN RADICAL EN EL LADO IZQUIERDO DEL RADICAL CONECTADO A C SELECCIONADO DE NR2-CO-NR2, NR2SO2-NR2, O-C(O)-NR2, NR2-C(O)-O, D(O)-NR2-C(O), ENTRE OTROS; Q ES UN ENLACE COVALENTE, CH2; W ES CH, N; X ES CR9R10, C=CH2, C=O; Y ES CR9R10, O, NR2; Z ES C=O, C=S, S(O)2; R1 ES H, (CH2)qN(X6)C(O)X6, (CH2)qN(X6)S(O)2(CH2)t-A1, ENTRE OTROS; q ES 0-4; t ES 0-3 SON COMPUESTOS PREFERIDOS {(R)-1-(4-CLOROBENCIL)-2-[1,3-DIOXO-(S)-8a-PIRIDIN-2-ILMETIL-2-(2,2,2,TRIFLUOROETIL)-HEXAHIDROIMIDAZOL[1,5-a]PIRAZIN-7-il]-2-OXOETIL} AMIDA DE ACIDO 1,2,3,4-TETRAHIDRO-ISOQUINOLIN-(S)-3-CARBOXILICO, {(R)-1-(4-CLOROBENCIL)-2-[(R)-8a-(4-FLUOROBENCIL)-2-METILl-1,3-DIOXOHEXAHIDRO-IMIDAZOLO[1,5-a]PIRAZIN-7-il]-2-OXOETIL} AMIDA DE ACIDO 1,2,3,4-TETRAHIDRO-ISOQUINOLIN-(R)-3-CARBOXILICO. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DERIVADOS DE N-HETEROCICLOS CONDENSADOS COMO LIGANDOS PARA RECEPTORES DE MELANOCORTINA JUNTO A INGREDIENTES ACTIVOS COMO SENSIBILIZADOR DE INSULINA, SULFONILUREA, INHIBIDOR DE O-GLUCOSIDASA, ENTRE OTROS UTILES PARA EL TRATAMIENTO DE LA OBESIDAD, DIABETES MELLITUS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21461600P | 2000-06-28 | 2000-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020208A1 true PE20020208A1 (es) | 2002-03-13 |
Family
ID=22799775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000626A PE20020208A1 (es) | 2000-06-28 | 2001-06-26 | Derivados de n-heterociclos condensados como ligandos para receptores de melanocortina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20020072604A1 (es) |
| EP (1) | EP1294719A1 (es) |
| JP (1) | JP2004501917A (es) |
| KR (1) | KR20030017571A (es) |
| CN (1) | CN1440406A (es) |
| AP (1) | AP2001002196A0 (es) |
| AR (1) | AR030301A1 (es) |
| AU (1) | AU2001260548A1 (es) |
| BG (1) | BG107268A (es) |
| BR (1) | BR0111567A (es) |
| CA (1) | CA2412563A1 (es) |
| EA (1) | EA200201119A1 (es) |
| EC (1) | ECSP024404A (es) |
| IL (1) | IL152781A0 (es) |
| IS (1) | IS6617A (es) |
| MA (1) | MA26920A1 (es) |
| MX (1) | MXPA03000063A (es) |
| NO (1) | NO20026280L (es) |
| OA (1) | OA12296A (es) |
| PA (1) | PA8521501A1 (es) |
| PE (1) | PE20020208A1 (es) |
| PL (1) | PL360855A1 (es) |
| TN (1) | TNSN01097A1 (es) |
| UY (1) | UY26804A1 (es) |
| WO (1) | WO2002000654A1 (es) |
| ZA (1) | ZA200210277B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001264977B2 (en) * | 2000-05-30 | 2005-04-14 | Merck & Co., Inc. | Melanocortin receptor agonists |
| CA2438272A1 (en) | 2001-03-02 | 2002-10-10 | John Macor | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| US6911447B2 (en) * | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| WO2003013571A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| CA2468015A1 (en) | 2001-11-27 | 2003-06-05 | Merck & Co., Inc. | 2-aminoquinoline compounds |
| US7026335B2 (en) | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| TW200504033A (en) | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| EP1595867A4 (en) | 2003-02-10 | 2008-05-21 | Banyu Pharma Co Ltd | PIPERIDINE DERIVATIVES AS AN ACTIVE ANTAGONIST AT THE RECIPE OF MELANIN CONCENTRATING HORMONE |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7795267B2 (en) | 2003-08-29 | 2010-09-14 | Takeda Pharmaceutical Company Limited | Bicyclic piperazine compound having TGR23 antagonistic activity |
| JP2005306839A (ja) * | 2003-08-29 | 2005-11-04 | Takeda Chem Ind Ltd | 二環性ピペラジン化合物およびその用途 |
| DE602005026380D1 (de) * | 2004-04-08 | 2011-03-31 | Astellas Pharma Inc | Verbindung ws727713 |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| ES2877349T3 (es) * | 2005-07-08 | 2021-11-16 | Ipsen Pharma | Ligandos de los receptores de la melanocortina |
| CA2617546C (en) | 2005-08-03 | 2014-07-15 | Boehringer Ingelheim International Gmbh | Use of flibanserin in the treatment of obesity |
| EP1945214A1 (en) | 2005-10-29 | 2008-07-23 | Boehringer Ingelheim International GmbH | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| JP2009541443A (ja) | 2006-06-30 | 2009-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁及び関連疾患の治療のためのフリバンセリン |
| EP2039695A4 (en) | 2006-07-11 | 2010-09-15 | Takeda Pharmaceutical | BICYCLIC HETEROCYLIC COMPOUND AND ITS USE |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| CA2660476C (en) | 2006-08-14 | 2015-11-17 | Boehringer Ingelheim International Gmbh | Formulations of flibanserin and method for manufacturing the same |
| JP5220746B2 (ja) | 2006-08-25 | 2013-06-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 制御放出システム及びその製造方法 |
| RU2450017C2 (ru) | 2007-05-25 | 2012-05-10 | Ипсен Фарма С.А.С. | Лиганды меланокортиновых рецепторов, модифицированные гидантоином |
| CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| US8288397B2 (en) | 2007-12-17 | 2012-10-16 | Janssen Pharmaceutica Nv | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1076649A4 (en) * | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE |
| EP1085869A4 (en) * | 1998-06-11 | 2001-10-04 | Merck & Co Inc | SPIRO PIPERID DERIVATIVES AS MELANOCORTIN RECEPTORAGONISTS |
| WO2000074679A1 (en) * | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
-
2001
- 2001-05-31 KR KR1020027017822A patent/KR20030017571A/ko not_active Application Discontinuation
- 2001-05-31 EA EA200201119A patent/EA200201119A1/ru unknown
- 2001-05-31 WO PCT/IB2001/000995 patent/WO2002000654A1/en not_active Application Discontinuation
- 2001-05-31 OA OA1200200389A patent/OA12296A/en unknown
- 2001-05-31 AP APAP/P/2001/002196A patent/AP2001002196A0/en unknown
- 2001-05-31 MX MXPA03000063A patent/MXPA03000063A/es unknown
- 2001-05-31 PL PL36085501A patent/PL360855A1/xx not_active Application Discontinuation
- 2001-05-31 JP JP2002505778A patent/JP2004501917A/ja not_active Withdrawn
- 2001-05-31 IL IL15278101A patent/IL152781A0/xx unknown
- 2001-05-31 CN CN01812163A patent/CN1440406A/zh active Pending
- 2001-05-31 CA CA002412563A patent/CA2412563A1/en not_active Abandoned
- 2001-05-31 BR BR0111567-7A patent/BR0111567A/pt not_active IP Right Cessation
- 2001-05-31 AU AU2001260548A patent/AU2001260548A1/en not_active Abandoned
- 2001-05-31 EP EP01934254A patent/EP1294719A1/en not_active Withdrawn
- 2001-06-25 US US09/891,026 patent/US20020072604A1/en not_active Abandoned
- 2001-06-26 PE PE2001000626A patent/PE20020208A1/es not_active Application Discontinuation
- 2001-06-26 AR ARP010103037A patent/AR030301A1/es unknown
- 2001-06-27 TN TNTNSN01097A patent/TNSN01097A1/fr unknown
- 2001-06-27 UY UY26804A patent/UY26804A1/es not_active Application Discontinuation
- 2001-06-28 PA PA20018521501A patent/PA8521501A1/es unknown
-
2002
- 2002-11-12 BG BG107268A patent/BG107268A/xx unknown
- 2002-11-14 IS IS6617A patent/IS6617A/is unknown
- 2002-12-19 ZA ZA200210277A patent/ZA200210277B/en unknown
- 2002-12-24 MA MA26976A patent/MA26920A1/fr unknown
- 2002-12-26 EC EC2002004404A patent/ECSP024404A/es unknown
- 2002-12-30 NO NO20026280A patent/NO20026280L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL360855A1 (en) | 2004-09-20 |
| WO2002000654A1 (en) | 2002-01-03 |
| EA200201119A1 (ru) | 2003-06-26 |
| OA12296A (en) | 2006-05-12 |
| NO20026280D0 (no) | 2002-12-30 |
| EP1294719A1 (en) | 2003-03-26 |
| MXPA03000063A (es) | 2003-09-25 |
| CA2412563A1 (en) | 2002-01-03 |
| KR20030017571A (ko) | 2003-03-03 |
| AU2001260548A1 (en) | 2002-01-08 |
| AP2001002196A0 (en) | 2002-12-21 |
| NO20026280L (no) | 2002-12-30 |
| ZA200210277B (en) | 2003-12-19 |
| BG107268A (en) | 2003-06-30 |
| BR0111567A (pt) | 2003-05-06 |
| PA8521501A1 (es) | 2002-10-24 |
| UY26804A1 (es) | 2002-01-31 |
| IL152781A0 (en) | 2003-06-24 |
| CN1440406A (zh) | 2003-09-03 |
| MA26920A1 (fr) | 2004-12-20 |
| AR030301A1 (es) | 2003-08-20 |
| US20020072604A1 (en) | 2002-06-13 |
| TNSN01097A1 (fr) | 2005-11-10 |
| ECSP024404A (es) | 2003-02-06 |
| IS6617A (is) | 2002-11-14 |
| JP2004501917A (ja) | 2004-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |