PE20011073A1 - Proceso para la preparacion de (3-cloro-4-fluorofenilo)-(7-(3-morfolina-4-ilopropoxi)-6-nitroquinazolina-4ilo)-amina o (3-cloro-4-fluorofenilo)-¦7-(3-morfolina-4-il-propoxi)-6-aminoquinazolina-4-ilo¦-amina - Google Patents

Proceso para la preparacion de (3-cloro-4-fluorofenilo)-(7-(3-morfolina-4-ilopropoxi)-6-nitroquinazolina-4ilo)-amina o (3-cloro-4-fluorofenilo)-¦7-(3-morfolina-4-il-propoxi)-6-aminoquinazolina-4-ilo¦-amina

Info

Publication number
PE20011073A1
PE20011073A1 PE2001000137A PE2001000137A PE20011073A1 PE 20011073 A1 PE20011073 A1 PE 20011073A1 PE 2001000137 A PE2001000137 A PE 2001000137A PE 2001000137 A PE2001000137 A PE 2001000137A PE 20011073 A1 PE20011073 A1 PE 20011073A1
Authority
PE
Peru
Prior art keywords
chloro
amine
fluorophenyl
ilo
morpholine
Prior art date
Application number
PE2001000137A
Other languages
English (en)
Inventor
Hubert Barth
Simon Schneider
Klaus Steiner
Original Assignee
Godecke Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Godecke Gmbh filed Critical Godecke Gmbh
Publication of PE20011073A1 publication Critical patent/PE20011073A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DE (3-CLORO-4-FLUOROFENIL)-[7-(3-MORFOLIN-4-ILO-PROPOXI)-6-NITROQUINAZOLIN-4-ILO]-AMINA DE FORMULA I, O (3-CLORO-4-FLUOROFENIL)-[7-(3-MORFOLIN-4-IL-PROPOXI)-6-AMINOQUINAZOLINA-4-ILO]-AMINA DE FORMULA VII; QUE COMPRENDE REACCIONAR 7-FLUORO-6-NITROQUINAZOLIN-4(3H)-ONA, CON CLORURO DE TIONILO PARA DAR 4-CLORO-7-FLUORO-6-NITROQUINAZOLINA; Y REACCIONAR CON 3-CLORO-4-FLUOROANILINA Y DAR 4-(3-CLORO-4-FLUOROANILIN)-7-FLUORO-6-NITROQUINAZOLIN, Y REACCIONAR CON 3-MORFOLIN-4-ILO PROPANO-1-OL Y DAR HIDROGENADOS DIRECTAMENTE EN LA SOLUCION DE REACCION PARA DAR EL COMPUESTO III
PE2001000137A 2000-02-26 2001-02-08 Proceso para la preparacion de (3-cloro-4-fluorofenilo)-(7-(3-morfolina-4-ilopropoxi)-6-nitroquinazolina-4ilo)-amina o (3-cloro-4-fluorofenilo)-¦7-(3-morfolina-4-il-propoxi)-6-aminoquinazolina-4-ilo¦-amina PE20011073A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10009267A DE10009267A1 (de) 2000-02-26 2000-02-26 Verfahren zur einfachen Herstellung von (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazolin-4-yl]-amin bzw. (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazolin-4-yl]-amin

Publications (1)

Publication Number Publication Date
PE20011073A1 true PE20011073A1 (es) 2001-12-16

Family

ID=7632648

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000137A PE20011073A1 (es) 2000-02-26 2001-02-08 Proceso para la preparacion de (3-cloro-4-fluorofenilo)-(7-(3-morfolina-4-ilopropoxi)-6-nitroquinazolina-4ilo)-amina o (3-cloro-4-fluorofenilo)-¦7-(3-morfolina-4-il-propoxi)-6-aminoquinazolina-4-ilo¦-amina

Country Status (31)

Country Link
US (1) US20030050313A1 (es)
EP (1) EP1265874B1 (es)
JP (1) JP2003524006A (es)
KR (1) KR20030011773A (es)
CN (1) CN1171877C (es)
AR (1) AR027377A1 (es)
AT (1) ATE296810T1 (es)
AU (1) AU2001228478A1 (es)
BR (1) BR0108695A (es)
CA (1) CA2401171A1 (es)
CO (1) CO5280058A1 (es)
DE (2) DE10009267A1 (es)
EA (1) EA005213B1 (es)
EG (1) EG23221A (es)
ES (1) ES2240483T3 (es)
GT (1) GT200100025A (es)
HK (1) HK1054551B (es)
HU (1) HUP0204510A3 (es)
IL (1) IL151206A0 (es)
MX (1) MXPA02008301A (es)
MY (1) MY133846A (es)
PA (1) PA8512701A1 (es)
PE (1) PE20011073A1 (es)
PL (1) PL357774A1 (es)
PT (1) PT1265874E (es)
SV (1) SV2002000320A (es)
TN (1) TNSN01031A1 (es)
UY (1) UY26594A1 (es)
WO (1) WO2001062743A2 (es)
YU (1) YU62502A (es)
ZA (1) ZA200206107B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20040945A1 (es) * 2003-02-05 2004-12-14 Warner Lambert Co Preparacion de quinazolinas substituidas
WO2006081741A1 (fr) * 2005-02-05 2006-08-10 Piaoyang Sun Dérivés de quinazoline ou leurs sels de qualité pharmaceutique, synthèse et applications médicales desdites substances
JP5250901B2 (ja) * 2007-02-23 2013-07-31 学校法人慶應義塾 アニリノキナゾリン系化合物及びその用途
US7829574B2 (en) * 2008-05-09 2010-11-09 Hutchison Medipharma Enterprises Limited Substituted quinazoline compounds and their use in treating angiogenesis-related diseases
CN105399688A (zh) * 2015-12-02 2016-03-16 西南科技大学 一种吉非替尼的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO121900B1 (ro) * 1996-04-12 2008-07-30 Warner-Lambert Company Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora

Also Published As

Publication number Publication date
CO5280058A1 (es) 2003-05-30
EA200200885A1 (ru) 2003-02-27
PA8512701A1 (es) 2002-02-21
KR20030011773A (ko) 2003-02-11
AR027377A1 (es) 2003-03-26
CA2401171A1 (en) 2001-08-30
TNSN01031A1 (en) 2005-11-10
BR0108695A (pt) 2002-12-10
HUP0204510A2 (en) 2003-05-28
EP1265874B1 (de) 2005-06-01
EA005213B1 (ru) 2004-12-30
YU62502A (sh) 2005-03-15
SV2002000320A (es) 2002-06-07
AU2001228478A1 (en) 2001-09-03
EG23221A (en) 2004-08-31
IL151206A0 (en) 2003-04-10
EP1265874A2 (de) 2002-12-18
WO2001062743A2 (de) 2001-08-30
MY133846A (en) 2007-11-30
GT200100025A (es) 2003-09-22
HK1054551A1 (en) 2003-12-05
JP2003524006A (ja) 2003-08-12
CN1406232A (zh) 2003-03-26
ZA200206107B (en) 2003-07-31
UY26594A1 (es) 2001-09-28
MXPA02008301A (es) 2004-05-14
HUP0204510A3 (en) 2003-07-28
WO2001062743A3 (de) 2002-03-14
HK1054551B (zh) 2005-06-03
ES2240483T3 (es) 2005-10-16
DE10009267A1 (de) 2001-08-30
DE50106391D1 (de) 2005-07-07
PT1265874E (pt) 2005-08-31
CN1171877C (zh) 2004-10-20
US20030050313A1 (en) 2003-03-13
PL357774A1 (en) 2004-07-26
ATE296810T1 (de) 2005-06-15

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