PE20010940A1 - Composiciones de valdecoxib - Google Patents
Composiciones de valdecoxibInfo
- Publication number
- PE20010940A1 PE20010940A1 PE2000001298A PE0012982000A PE20010940A1 PE 20010940 A1 PE20010940 A1 PE 20010940A1 PE 2000001298 A PE2000001298 A PE 2000001298A PE 0012982000 A PE0012982000 A PE 0012982000A PE 20010940 A1 PE20010940 A1 PE 20010940A1
- Authority
- PE
- Peru
- Prior art keywords
- administration
- refers
- reach
- particle size
- valdecoxib
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002004 valdecoxib Drugs 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 3
- 229920000881 Modified starch Polymers 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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- A61K9/2022—Organic macromolecular compounds
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- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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- C07D307/58—One oxygen atom, e.g. butenolide
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- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
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- Diabetes (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
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- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US16985699P | 1999-12-08 | 1999-12-08 | |
| US18163500P | 2000-02-10 | 2000-02-10 | |
| US20226900P | 2000-05-05 | 2000-05-05 |
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| PE20010940A1 true PE20010940A1 (es) | 2001-09-12 |
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| PE2000001298A PE20010940A1 (es) | 1999-12-08 | 2000-12-06 | Composiciones de valdecoxib |
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| JP (1) | JP2003516353A (https=) |
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| CN (2) | CN1203852C (https=) |
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| AU (3) | AU1930301A (https=) |
| BG (1) | BG105873A (https=) |
| BR (1) | BR0008059A (https=) |
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| HU (1) | HUP0200409A3 (https=) |
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| MY (1) | MY138227A (https=) |
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| PL (1) | PL351069A1 (https=) |
| SK (1) | SK12692001A3 (https=) |
| TR (1) | TR200102297T1 (https=) |
| TW (1) | TWI265808B (https=) |
| WO (2) | WO2001041761A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2251361T3 (es) | 1998-10-30 | 2006-05-01 | Rj Innovation | Un metodo de prevencion de hipocalcemia puerperal en animales y composiciones utilizadas en el mismo. |
| GEP20053427B (en) | 1999-12-23 | 2005-01-25 | Pfizer Prod Inc | Pharmaceutical Compositions Providing Enhanced Drug Concentrations |
| CN1638739A (zh) * | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
| AU2002303577B2 (en) * | 2001-05-04 | 2006-06-08 | Merck & Co., Inc. | Method and compositions for treating migraines |
| MXPA04002798A (es) * | 2001-09-26 | 2004-07-05 | Pharmacia Corp | Composiciones de valdecoxib de disgregacion intraoral. |
| BR0213152A (pt) * | 2001-10-10 | 2004-10-19 | Pharmacia Corp | Composições de valdecoxib de desintegração intraoral preparadas por processo de secagem por pulverização |
| GB0124459D0 (en) * | 2001-10-11 | 2001-12-05 | Novartis Ag | Organic compounds |
| JP2005512990A (ja) * | 2001-11-07 | 2005-05-12 | ファルマシア・コーポレーション | 流動層造粒法により製造される口腔内崩壊型バルデコキシブ組成物 |
| ES2297032T3 (es) * | 2001-11-13 | 2008-05-01 | Pharmacia Corporation | Forma de dosificacion oral de parecoxib. |
| WO2003057166A2 (en) * | 2002-01-07 | 2003-07-17 | Pharmacia Corporation | Treatment of pain, inflammation, and inflammation-related disorders with a combination of a cyclooxygenase-2 selective inhibitor and aspirin |
| GB0201520D0 (en) * | 2002-01-23 | 2002-03-13 | Novartis Ag | Pharmaceutical uses |
| WO2004000284A1 (en) * | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| WO2004026235A2 (en) * | 2002-09-20 | 2004-04-01 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| RU2286151C2 (ru) * | 2002-02-22 | 2006-10-27 | Уорнер-Ламберт Компани Ллс | Комбинации альфа-2-дельта-лиганда с селективным ингибитором циклооксигеназы-2 |
| CA2477923C (en) * | 2002-03-01 | 2021-02-23 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| GB0209257D0 (en) * | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| GB0209265D0 (en) * | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| MXPA05000011A (es) * | 2002-06-26 | 2005-04-08 | Pharmacia Corp | Formulacion parenteral liquida estable de parecoxib. |
| BR0313773A (pt) * | 2002-08-30 | 2005-06-21 | Pharmacia Corp | Formas farmacêuticas de dosagem sólida exibindo perfil de liberação de fármaco reprodutìvel |
| JP4494712B2 (ja) * | 2002-11-12 | 2010-06-30 | 大日本住友製薬株式会社 | マルチプルユニット型徐放性製剤 |
| PT1562567T (pt) | 2002-11-22 | 2017-08-24 | Gruenenthal Gmbh | Combinação de analgésicos selecionados e inibidores da cox-ii |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| US20050070524A1 (en) * | 2003-06-06 | 2005-03-31 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders |
| US20050004224A1 (en) * | 2003-06-10 | 2005-01-06 | Pharmacia Corporation | Treatment of Alzheimer's disease with the R(-) isomer of a 2-arylpropionic acid non-steroidal anti-inflammatory drug alone or in combination with a cyclooxygenase-2 selective inhibitor |
| US20050080083A1 (en) * | 2003-07-10 | 2005-04-14 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an angiotensin II receptor antagonist for the treatment of central nervous system damage |
| WO2005041864A2 (en) * | 2003-10-21 | 2005-05-12 | Pharmacia Corporation | Combination of cyclooxygenase-2 inhibitor and phosphodiesterase 4 inhibitor and method |
| CN101010072A (zh) | 2004-09-01 | 2007-08-01 | 欧洲凯尔特公司 | 具有与剂量成比例的稳态Cave和AUC并且小于与剂量成比例的单剂量CMAX的阿片类物质剂量形式 |
| JP2008534591A (ja) * | 2005-03-29 | 2008-08-28 | マクニール−ピーピーシー・インコーポレーテツド | 疎水性溶媒内に親水性薬剤を有する組成物 |
| PT1885339E (pt) * | 2005-05-05 | 2015-10-12 | Bristol Myers Squibb Holdings Ireland | Formulações de um inibidor src/abl |
| US7942818B2 (en) * | 2006-02-01 | 2011-05-17 | University Of Florida Research Foundation, Inc. | Obstetric analgesia system |
| US8231907B2 (en) | 2006-03-21 | 2012-07-31 | Morehouse School Of Medicine | Nanoparticles for delivery of active agents |
| EP1923053A1 (en) * | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| EP2124901B1 (en) | 2007-02-01 | 2017-07-19 | Takeda Pharmaceutical Company Limited | Tablet preparation without causing a tableting trouble |
| FR2963889B1 (fr) * | 2010-08-20 | 2013-04-12 | Debregeas Et Associes Pharma | Formulations a base de nalbuphine et leurs utilisations |
| EA202090321A1 (ru) * | 2017-08-14 | 2020-09-24 | Спрюс Биосайнсес, Инк. | Антагонисты рецептора кортикотропин-рилизинг фактора |
| CN118845788A (zh) | 2017-08-14 | 2024-10-29 | 云杉生物科学公司 | 促肾上腺皮质激素释放因子受体拮抗剂 |
| EP4438124A3 (en) | 2018-04-27 | 2024-12-18 | Spruce Biosciences, Inc. | Methods for treating testicular and ovarian adrenal rest tumors |
| CN108644512B (zh) * | 2018-07-09 | 2023-06-30 | 南京氟源化工管道设备有限公司 | 一种钢衬聚四氟乙烯三通及其模压工艺 |
| WO2020135401A1 (zh) * | 2018-12-24 | 2020-07-02 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物的治疗用途及其固体药物组合物 |
| BR112023002497A2 (pt) | 2020-08-12 | 2023-05-02 | Spruce Biosciences Inc | Métodos e composições para tratamento da síndrome dos ovários policísticos |
| US11273128B1 (en) * | 2021-04-15 | 2022-03-15 | Sandoz Ag | Elagolix formulation |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2183935T3 (es) * | 1995-02-13 | 2003-04-01 | Searle & Co | Isoxazoles sustituidos para el tratamiento de la inflamacion. |
| EP0863134A1 (en) * | 1997-03-07 | 1998-09-09 | Merck Frosst Canada Inc. | 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2 |
| SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
| ATE306263T1 (de) * | 1999-03-10 | 2005-10-15 | Searle Llc | Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere |
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2000
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- 2000-12-04 EE EEP200100414A patent/EE200100414A/xx unknown
- 2000-12-04 AU AU19303/01A patent/AU1930301A/en not_active Abandoned
- 2000-12-04 CA CA002362816A patent/CA2362816C/en not_active Expired - Fee Related
- 2000-12-04 CN CNB008059063A patent/CN1203852C/zh not_active Expired - Fee Related
- 2000-12-04 TR TR2001/02297T patent/TR200102297T1/xx unknown
- 2000-12-04 PL PL00351069A patent/PL351069A1/xx not_active Application Discontinuation
- 2000-12-04 WO PCT/US2000/032417 patent/WO2001041761A2/en not_active Ceased
- 2000-12-04 IL IL14476300A patent/IL144763A0/xx active IP Right Grant
- 2000-12-04 KR KR1020017010031A patent/KR100664479B1/ko not_active Expired - Fee Related
- 2000-12-04 CN CNA200510065059XA patent/CN1679556A/zh active Pending
- 2000-12-04 BR BR0008059-4A patent/BR0008059A/pt not_active Application Discontinuation
- 2000-12-04 HR HR20010582A patent/HRP20010582A2/hr not_active Application Discontinuation
- 2000-12-04 KR KR1020067002453A patent/KR100645866B1/ko not_active Expired - Fee Related
- 2000-12-06 EA EA200100872A patent/EA003639B1/ru not_active IP Right Cessation
- 2000-12-06 CZ CZ20013163A patent/CZ20013163A3/cs unknown
- 2000-12-06 HK HK02102619.5A patent/HK1041637A1/zh unknown
- 2000-12-06 WO PCT/US2000/032433 patent/WO2001041762A2/en not_active Ceased
- 2000-12-06 EP EP00982254A patent/EP1165072A2/en not_active Ceased
- 2000-12-06 AU AU19310/01A patent/AU777402B2/en not_active Ceased
- 2000-12-06 TW TW089125989A patent/TWI265808B/zh not_active IP Right Cessation
- 2000-12-06 HU HU0200409A patent/HUP0200409A3/hu unknown
- 2000-12-06 NZ NZ513963A patent/NZ513963A/en unknown
- 2000-12-06 SK SK1269-2001A patent/SK12692001A3/sk unknown
- 2000-12-06 PE PE2000001298A patent/PE20010940A1/es not_active Application Discontinuation
- 2000-12-06 US US09/731,349 patent/US20020013357A1/en not_active Abandoned
- 2000-12-06 AR ARP000106472A patent/AR027896A1/es unknown
- 2000-12-06 MY MYPI20005731A patent/MY138227A/en unknown
- 2000-12-11 CO CO00094074A patent/CO5261582A1/es unknown
-
2001
- 2001-08-06 IL IL144763A patent/IL144763A/en not_active IP Right Cessation
- 2001-08-07 IS IS6040A patent/IS6040A/is unknown
- 2001-08-08 NO NO20013858A patent/NO20013858L/no not_active Application Discontinuation
- 2001-09-04 BG BG105873A patent/BG105873A/bg unknown
- 2001-09-11 CR CR6458A patent/CR6458A/es not_active Application Discontinuation
-
2005
- 2005-01-04 AU AU2005200015A patent/AU2005200015A1/en not_active Abandoned
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