PE20000881A1 - Uso de tiazolidindiona como cardioprotector - Google Patents

Uso de tiazolidindiona como cardioprotector

Info

Publication number
PE20000881A1
PE20000881A1 PE1999000726A PE00072699A PE20000881A1 PE 20000881 A1 PE20000881 A1 PE 20000881A1 PE 1999000726 A PE1999000726 A PE 1999000726A PE 00072699 A PE00072699 A PE 00072699A PE 20000881 A1 PE20000881 A1 PE 20000881A1
Authority
PE
Peru
Prior art keywords
diona
benzyl
thiazolidine
methyl
metoxy
Prior art date
Application number
PE1999000726A
Other languages
English (en)
Inventor
Robin Edwin Buckingham
Antoine Michel Alain Bril
Nassirah Khandoudi
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815871.0A external-priority patent/GB9815871D0/en
Priority claimed from GBGB9815872.8A external-priority patent/GB9815872D0/en
Application filed by Smithkline Beecham Plc, Smithkline Beecham Lab filed Critical Smithkline Beecham Plc
Publication of PE20000881A1 publication Critical patent/PE20000881A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

SE REFIERE AL USO DE UN INTENSIFICADOR DE LA ABSORCION DE GLUCOSA TAL COMO TIAZOLIDINDIONA DE PREFERENCIA 5-[4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL]-TIAZOLIDINA-2,4-DIONA, (+)-5-[[4-[(3,4-DIHIDRO-6-HIDROXI-2,5,7,8-TETRAMETIL-2H-1-BENZOPIRAN-2-IL)METOXI]FENIL]METIL]-2,4-TIAZOLIDINA (TROGLITAZONA), 5-[4-[(1-METILCICLOHEXIL)METOXI]BENCIL]TIAZOLIDINA-2,4-DIONA (CIGLITAZONA), 5-[4-[2-(5-ETILPIRIDIN-2-IL)ETOXI]-BENCIL]-TIAZOLIDINA-2,4-DIONA (PIOGLITAZONA); 5-[(2-BENCIL-2,3-DIHIDROBENZOPIRAN)-5-ILMETIL]TIAZOLIDINA-2,4-DIONA (ENGLITAZONA) COMO CARDIOPROTECTOR EN UNA PERSONA DIABETICA O PARA REDUCIR O PREVENIR LA APOPTOSIS DE CELULAS DIFERENCIADAS COMO MIOCITOS, CELULAS ß-PANCREATICAS, CELULAS ENDOTELIALES Y CELULAS NEURONALES INDUCIDA POR ATAQUE ISQUEMICO, PRIVACION DE SUERO, ACTIVACION DE CITOQUINAS, REDUCIR LA LESION O MEJORAR LA RECUPERACION FUNCIONAL DEL CORAZON POSTERIOR A LA ISQUEMIA
PE1999000726A 1998-07-21 1999-07-20 Uso de tiazolidindiona como cardioprotector PE20000881A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815871.0A GB9815871D0 (en) 1998-07-21 1998-07-21 Novel compound
GBGB9815872.8A GB9815872D0 (en) 1998-07-21 1998-07-21 Novel method

Publications (1)

Publication Number Publication Date
PE20000881A1 true PE20000881A1 (es) 2000-10-07

Family

ID=26314086

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000726A PE20000881A1 (es) 1998-07-21 1999-07-20 Uso de tiazolidindiona como cardioprotector

Country Status (35)

Country Link
EP (2) EP1523980A3 (es)
JP (1) JP2002521325A (es)
KR (1) KR20010079550A (es)
CN (1) CN1167416C (es)
AP (1) AP1416A (es)
AR (1) AR020614A1 (es)
AT (1) ATE318588T1 (es)
AU (1) AU5053599A (es)
BG (1) BG105251A (es)
BR (1) BR9912144A (es)
CA (1) CA2338216A1 (es)
CO (1) CO5060465A1 (es)
CY (1) CY1106078T1 (es)
CZ (1) CZ2001250A3 (es)
DE (1) DE69930125T2 (es)
DK (1) DK1098638T3 (es)
DZ (1) DZ2854A1 (es)
EA (1) EA004772B1 (es)
ES (1) ES2259839T3 (es)
GC (1) GC0000173A (es)
HU (1) HUP0103870A3 (es)
ID (1) ID27850A (es)
IL (1) IL140741A0 (es)
MA (1) MA26662A1 (es)
NO (1) NO20010293L (es)
NZ (1) NZ509175A (es)
OA (1) OA11583A (es)
PE (1) PE20000881A1 (es)
PL (1) PL345663A1 (es)
PT (1) PT1098638E (es)
SI (1) SI1098638T1 (es)
SK (1) SK1022001A3 (es)
TR (1) TR200100208T2 (es)
TW (2) TW200307532A (es)
WO (1) WO2000004889A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417212B1 (en) 1999-08-27 2002-07-09 Eli Lilly & Company Modulators of peroxisome proliferator activated receptors
WO2001095906A1 (en) * 2000-06-16 2001-12-20 Smithkline Beecham P.L.C. Treatment and prevention of cardiac insulin resistance associated conditions
MXPA04000695A (es) 2001-07-23 2005-08-26 Galileo Pharmaceuticals Inc Compuestos citoprotectores, formulaciones farmaceuticas y cosmeticas y metodos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG59988A1 (en) * 1987-09-04 1999-02-22 Beecham Group Plc Substituted thiazolidinedione derivatives
JPH05202042A (ja) * 1992-01-24 1993-08-10 Sankyo Co Ltd 糖尿病性合併症治療剤
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
GB9611947D0 (en) * 1996-06-07 1996-08-07 Glaxo Group Ltd Medicaments
US6277819B1 (en) * 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
HUP0002941A3 (en) * 1996-09-12 2001-11-28 Sankyo Company Ltd Chuo Ku Glutathione reductase activity potentiator containing troglitazone
CA2311125C (en) * 1997-11-19 2011-01-18 Takeda Chemical Industries, Ltd. Apoptosis inhibitor
AU2781899A (en) * 1998-02-24 1999-09-15 Trustees Of The University Of Pennsylvania, The Use of a cardiac purinoceptor to effect cellular glucose uptake
WO1999059586A1 (en) * 1998-05-19 1999-11-25 Regents Of The University Of California Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
US5968960A (en) * 1999-01-14 1999-10-19 The Regents Of The University Of California Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism

Also Published As

Publication number Publication date
CO5060465A1 (es) 2001-07-30
TR200100208T2 (tr) 2001-05-21
NO20010293D0 (no) 2001-01-18
HUP0103870A2 (hu) 2002-05-29
HUP0103870A3 (en) 2003-06-30
KR20010079550A (ko) 2001-08-22
BG105251A (en) 2001-10-31
AP2001002033A0 (en) 2001-03-31
JP2002521325A (ja) 2002-07-16
PL345663A1 (en) 2002-01-02
NO20010293L (no) 2001-03-07
AU5053599A (en) 2000-02-14
TWI239836B (en) 2005-09-21
EP1098638A1 (en) 2001-05-16
TW200307532A (en) 2003-12-16
CZ2001250A3 (cs) 2002-03-13
PT1098638E (pt) 2006-07-31
SI1098638T1 (sl) 2006-06-30
BR9912144A (pt) 2001-04-03
OA11583A (en) 2004-07-01
EP1523980A3 (en) 2009-03-18
EP1523980A2 (en) 2005-04-20
ATE318588T1 (de) 2006-03-15
ID27850A (id) 2001-04-26
AP1416A (en) 2005-06-13
AR020614A1 (es) 2002-05-22
ES2259839T3 (es) 2006-10-16
DE69930125T2 (de) 2006-10-05
WO2000004889A1 (en) 2000-02-03
GC0000173A (en) 2006-03-29
DK1098638T3 (da) 2006-06-19
DE69930125D1 (de) 2006-04-27
SK1022001A3 (en) 2001-08-06
IL140741A0 (en) 2002-02-10
MA26662A1 (fr) 2004-12-20
CY1106078T1 (el) 2011-06-08
EA004772B1 (ru) 2004-08-26
CN1167416C (zh) 2004-09-22
DZ2854A1 (fr) 2003-12-01
EA200100164A1 (ru) 2001-08-27
CN1310619A (zh) 2001-08-29
CA2338216A1 (en) 2000-02-03
EP1098638B1 (en) 2006-03-01
NZ509175A (en) 2003-10-31

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