PE20000881A1 - Uso de tiazolidindiona como cardioprotector - Google Patents

Uso de tiazolidindiona como cardioprotector

Info

Publication number
PE20000881A1
PE20000881A1 PE1999000726A PE00072699A PE20000881A1 PE 20000881 A1 PE20000881 A1 PE 20000881A1 PE 1999000726 A PE1999000726 A PE 1999000726A PE 00072699 A PE00072699 A PE 00072699A PE 20000881 A1 PE20000881 A1 PE 20000881A1
Authority
PE
Peru
Prior art keywords
diona
benzyl
thiazolidine
methyl
metoxy
Prior art date
Application number
PE1999000726A
Other languages
English (en)
Inventor
Robin Edwin Buckingham
Antoine Michel Alain Bril
Nassirah Khandoudi
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815872.8A external-priority patent/GB9815872D0/en
Priority claimed from GBGB9815871.0A external-priority patent/GB9815871D0/en
Application filed by Smithkline Beecham Plc, Smithkline Beecham Lab filed Critical Smithkline Beecham Plc
Publication of PE20000881A1 publication Critical patent/PE20000881A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE REFIERE AL USO DE UN INTENSIFICADOR DE LA ABSORCION DE GLUCOSA TAL COMO TIAZOLIDINDIONA DE PREFERENCIA 5-[4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL]-TIAZOLIDINA-2,4-DIONA, (+)-5-[[4-[(3,4-DIHIDRO-6-HIDROXI-2,5,7,8-TETRAMETIL-2H-1-BENZOPIRAN-2-IL)METOXI]FENIL]METIL]-2,4-TIAZOLIDINA (TROGLITAZONA), 5-[4-[(1-METILCICLOHEXIL)METOXI]BENCIL]TIAZOLIDINA-2,4-DIONA (CIGLITAZONA), 5-[4-[2-(5-ETILPIRIDIN-2-IL)ETOXI]-BENCIL]-TIAZOLIDINA-2,4-DIONA (PIOGLITAZONA); 5-[(2-BENCIL-2,3-DIHIDROBENZOPIRAN)-5-ILMETIL]TIAZOLIDINA-2,4-DIONA (ENGLITAZONA) COMO CARDIOPROTECTOR EN UNA PERSONA DIABETICA O PARA REDUCIR O PREVENIR LA APOPTOSIS DE CELULAS DIFERENCIADAS COMO MIOCITOS, CELULAS ß-PANCREATICAS, CELULAS ENDOTELIALES Y CELULAS NEURONALES INDUCIDA POR ATAQUE ISQUEMICO, PRIVACION DE SUERO, ACTIVACION DE CITOQUINAS, REDUCIR LA LESION O MEJORAR LA RECUPERACION FUNCIONAL DEL CORAZON POSTERIOR A LA ISQUEMIA
PE1999000726A 1998-07-21 1999-07-20 Uso de tiazolidindiona como cardioprotector PE20000881A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815872.8A GB9815872D0 (en) 1998-07-21 1998-07-21 Novel method
GBGB9815871.0A GB9815871D0 (en) 1998-07-21 1998-07-21 Novel compound

Publications (1)

Publication Number Publication Date
PE20000881A1 true PE20000881A1 (es) 2000-10-07

Family

ID=26314086

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000726A PE20000881A1 (es) 1998-07-21 1999-07-20 Uso de tiazolidindiona como cardioprotector

Country Status (35)

Country Link
EP (2) EP1523980A3 (es)
JP (1) JP2002521325A (es)
KR (1) KR20010079550A (es)
CN (1) CN1167416C (es)
AP (1) AP1416A (es)
AR (1) AR020614A1 (es)
AT (1) ATE318588T1 (es)
AU (1) AU5053599A (es)
BG (1) BG105251A (es)
BR (1) BR9912144A (es)
CA (1) CA2338216A1 (es)
CO (1) CO5060465A1 (es)
CY (1) CY1106078T1 (es)
CZ (1) CZ2001250A3 (es)
DE (1) DE69930125T2 (es)
DK (1) DK1098638T3 (es)
DZ (1) DZ2854A1 (es)
EA (1) EA004772B1 (es)
ES (1) ES2259839T3 (es)
GC (1) GC0000173A (es)
HU (1) HUP0103870A3 (es)
ID (1) ID27850A (es)
IL (1) IL140741A0 (es)
MA (1) MA26662A1 (es)
NO (1) NO20010293L (es)
NZ (1) NZ509175A (es)
OA (1) OA11583A (es)
PE (1) PE20000881A1 (es)
PL (1) PL345663A1 (es)
PT (1) PT1098638E (es)
SI (1) SI1098638T1 (es)
SK (1) SK1022001A3 (es)
TR (1) TR200100208T2 (es)
TW (2) TWI239836B (es)
WO (1) WO2000004889A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016120A1 (en) 1999-08-27 2001-03-08 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
BR0017254A (pt) * 2000-06-16 2004-01-06 Smithkline Beecham Plc Tratamento e prevenção de condições associadas à resistência cardìaca à insulina
CA2452159A1 (en) 2001-07-23 2003-02-06 Galileo Laboratories, Inc. Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
JPH05202042A (ja) * 1992-01-24 1993-08-10 Sankyo Co Ltd 糖尿病性合併症治療剤
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
GB9611947D0 (en) * 1996-06-07 1996-08-07 Glaxo Group Ltd Medicaments
US6277819B1 (en) * 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
IL128771A0 (en) * 1996-09-12 2000-01-31 Sankyo Co An agent for enhancing the activity of glutathione reductase containing troglitazone and use thereof
EP1047423B1 (en) * 1997-11-19 2006-05-10 Takeda Pharmaceutical Company Limited Novel apoptosis inhibitors
AU2781899A (en) * 1998-02-24 1999-09-15 Trustees Of The University Of Pennsylvania, The Use of a cardiac purinoceptor to effect cellular glucose uptake
WO1999059586A1 (en) * 1998-05-19 1999-11-25 Regents Of The University Of California Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
US5968960A (en) * 1999-01-14 1999-10-19 The Regents Of The University Of California Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism

Also Published As

Publication number Publication date
CO5060465A1 (es) 2001-07-30
EP1098638B1 (en) 2006-03-01
AP2001002033A0 (en) 2001-03-31
AP1416A (en) 2005-06-13
EP1523980A3 (en) 2009-03-18
KR20010079550A (ko) 2001-08-22
DK1098638T3 (da) 2006-06-19
TWI239836B (en) 2005-09-21
IL140741A0 (en) 2002-02-10
DE69930125T2 (de) 2006-10-05
CY1106078T1 (el) 2011-06-08
NO20010293D0 (no) 2001-01-18
SK1022001A3 (en) 2001-08-06
EP1098638A1 (en) 2001-05-16
TW200307532A (en) 2003-12-16
EP1523980A2 (en) 2005-04-20
CA2338216A1 (en) 2000-02-03
PL345663A1 (en) 2002-01-02
EA004772B1 (ru) 2004-08-26
BR9912144A (pt) 2001-04-03
AU5053599A (en) 2000-02-14
CN1167416C (zh) 2004-09-22
SI1098638T1 (sl) 2006-06-30
JP2002521325A (ja) 2002-07-16
BG105251A (en) 2001-10-31
WO2000004889A1 (en) 2000-02-03
ID27850A (id) 2001-04-26
OA11583A (en) 2004-07-01
TR200100208T2 (tr) 2001-05-21
CN1310619A (zh) 2001-08-29
NZ509175A (en) 2003-10-31
NO20010293L (no) 2001-03-07
HUP0103870A2 (hu) 2002-05-29
DE69930125D1 (de) 2006-04-27
ATE318588T1 (de) 2006-03-15
HUP0103870A3 (en) 2003-06-30
DZ2854A1 (fr) 2003-12-01
GC0000173A (en) 2006-03-29
CZ2001250A3 (cs) 2002-03-13
PT1098638E (pt) 2006-07-31
MA26662A1 (fr) 2004-12-20
ES2259839T3 (es) 2006-10-16
AR020614A1 (es) 2002-05-22
EA200100164A1 (ru) 2001-08-27

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