SI1098638T1 - Uporaba aktivatorja navzema glukoze za zmanjsanjepostishemicnih poskodb srca - Google Patents

Uporaba aktivatorja navzema glukoze za zmanjsanjepostishemicnih poskodb srca

Info

Publication number
SI1098638T1
SI1098638T1 SI9930889T SI9930889T SI1098638T1 SI 1098638 T1 SI1098638 T1 SI 1098638T1 SI 9930889 T SI9930889 T SI 9930889T SI 9930889 T SI9930889 T SI 9930889T SI 1098638 T1 SI1098638 T1 SI 1098638T1
Authority
SI
Slovenia
Prior art keywords
heart
glucose uptake
ischemic injury
reducing post
uptake enhancer
Prior art date
Application number
SI9930889T
Other languages
English (en)
Inventor
Antoine Michel A S Bril
Robin Edwin Buckingham
Nassirah Khandoudi
Original Assignee
Smithkline Beecham Plc
Glaxosmithkline Lab Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815871.0A external-priority patent/GB9815871D0/en
Priority claimed from GBGB9815872.8A external-priority patent/GB9815872D0/en
Application filed by Smithkline Beecham Plc, Glaxosmithkline Lab Sas filed Critical Smithkline Beecham Plc
Publication of SI1098638T1 publication Critical patent/SI1098638T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
SI9930889T 1998-07-21 1999-07-21 Uporaba aktivatorja navzema glukoze za zmanjsanjepostishemicnih poskodb srca SI1098638T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9815871.0A GB9815871D0 (en) 1998-07-21 1998-07-21 Novel compound
GBGB9815872.8A GB9815872D0 (en) 1998-07-21 1998-07-21 Novel method
PCT/GB1999/002358 WO2000004889A1 (en) 1998-07-21 1999-07-21 Use of glucose uptake enhancer for reducing post-ischemic injury of the heart
EP99934911A EP1098638B1 (en) 1998-07-21 1999-07-21 Use of a glucose uptake enhancer for reducing post-ischemic injury of the heart

Publications (1)

Publication Number Publication Date
SI1098638T1 true SI1098638T1 (sl) 2006-06-30

Family

ID=26314086

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930889T SI1098638T1 (sl) 1998-07-21 1999-07-21 Uporaba aktivatorja navzema glukoze za zmanjsanjepostishemicnih poskodb srca

Country Status (35)

Country Link
EP (2) EP1098638B1 (sl)
JP (1) JP2002521325A (sl)
KR (1) KR20010079550A (sl)
CN (1) CN1167416C (sl)
AP (1) AP1416A (sl)
AR (1) AR020614A1 (sl)
AT (1) ATE318588T1 (sl)
AU (1) AU5053599A (sl)
BG (1) BG105251A (sl)
BR (1) BR9912144A (sl)
CA (1) CA2338216A1 (sl)
CO (1) CO5060465A1 (sl)
CY (1) CY1106078T1 (sl)
CZ (1) CZ2001250A3 (sl)
DE (1) DE69930125T2 (sl)
DK (1) DK1098638T3 (sl)
DZ (1) DZ2854A1 (sl)
EA (1) EA004772B1 (sl)
ES (1) ES2259839T3 (sl)
GC (1) GC0000173A (sl)
HU (1) HUP0103870A3 (sl)
ID (1) ID27850A (sl)
IL (1) IL140741A0 (sl)
MA (1) MA26662A1 (sl)
NO (1) NO20010293L (sl)
NZ (1) NZ509175A (sl)
OA (1) OA11583A (sl)
PE (1) PE20000881A1 (sl)
PL (1) PL345663A1 (sl)
PT (1) PT1098638E (sl)
SI (1) SI1098638T1 (sl)
SK (1) SK1022001A3 (sl)
TR (1) TR200100208T2 (sl)
TW (2) TW200307532A (sl)
WO (1) WO2000004889A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508389A (ja) 1999-08-27 2003-03-04 エリ リリー アンド カンパニー ビアリール−オキサ(チア)ゾール誘導体およびそのpparモジュレーターとしての使用
WO2001095906A1 (en) * 2000-06-16 2001-12-20 Smithkline Beecham P.L.C. Treatment and prevention of cardiac insulin resistance associated conditions
EP1435894A4 (en) 2001-07-23 2005-07-06 Galileo Pharmaceuticals Inc CYTOPROTECTIVE COMPOUNDS, METHODS AND PHARMACEUTICAL AND COSMETIC FORMULATIONS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0842925A1 (en) * 1987-09-04 1998-05-20 Beecham Group Plc Substituted thiazolidinedione derivatives
JPH05202042A (ja) * 1992-01-24 1993-08-10 Sankyo Co Ltd 糖尿病性合併症治療剤
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
GB9611947D0 (en) * 1996-06-07 1996-08-07 Glaxo Group Ltd Medicaments
US6277819B1 (en) * 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
CN1235543A (zh) * 1996-09-12 1999-11-17 三共株式会社 含有曲格列酮的谷胱甘肽还原酶活性增强剂
AU1172999A (en) * 1997-11-19 1999-06-07 Takeda Chemical Industries Ltd. Novel apoptosis inhibitors
AU2781899A (en) * 1998-02-24 1999-09-15 Trustees Of The University Of Pennsylvania, The Use of a cardiac purinoceptor to effect cellular glucose uptake
WO1999059586A1 (en) * 1998-05-19 1999-11-25 Regents Of The University Of California Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
US5968960A (en) * 1999-01-14 1999-10-19 The Regents Of The University Of California Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism

Also Published As

Publication number Publication date
WO2000004889A1 (en) 2000-02-03
NZ509175A (en) 2003-10-31
EA004772B1 (ru) 2004-08-26
DZ2854A1 (fr) 2003-12-01
AP1416A (en) 2005-06-13
GC0000173A (en) 2006-03-29
CY1106078T1 (el) 2011-06-08
PT1098638E (pt) 2006-07-31
ID27850A (id) 2001-04-26
DE69930125D1 (de) 2006-04-27
CO5060465A1 (es) 2001-07-30
OA11583A (en) 2004-07-01
CN1167416C (zh) 2004-09-22
EP1523980A3 (en) 2009-03-18
PE20000881A1 (es) 2000-10-07
AU5053599A (en) 2000-02-14
CA2338216A1 (en) 2000-02-03
AR020614A1 (es) 2002-05-22
HUP0103870A3 (en) 2003-06-30
NO20010293D0 (no) 2001-01-18
HUP0103870A2 (hu) 2002-05-29
DE69930125T2 (de) 2006-10-05
EP1098638A1 (en) 2001-05-16
TWI239836B (en) 2005-09-21
BR9912144A (pt) 2001-04-03
EA200100164A1 (ru) 2001-08-27
IL140741A0 (en) 2002-02-10
TR200100208T2 (tr) 2001-05-21
CN1310619A (zh) 2001-08-29
EP1098638B1 (en) 2006-03-01
AP2001002033A0 (en) 2001-03-31
ATE318588T1 (de) 2006-03-15
SK1022001A3 (en) 2001-08-06
JP2002521325A (ja) 2002-07-16
NO20010293L (no) 2001-03-07
BG105251A (en) 2001-10-31
MA26662A1 (fr) 2004-12-20
EP1523980A2 (en) 2005-04-20
TW200307532A (en) 2003-12-16
KR20010079550A (ko) 2001-08-22
PL345663A1 (en) 2002-01-02
ES2259839T3 (es) 2006-10-16
CZ2001250A3 (cs) 2002-03-13
DK1098638T3 (da) 2006-06-19

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