PE20000725A1 - Compuestos de alcoxipirrolidinona como inhibidores de proteasas - Google Patents

Compuestos de alcoxipirrolidinona como inhibidores de proteasas

Info

Publication number
PE20000725A1
PE20000725A1 PE1999000518A PE00051899A PE20000725A1 PE 20000725 A1 PE20000725 A1 PE 20000725A1 PE 1999000518 A PE1999000518 A PE 1999000518A PE 00051899 A PE00051899 A PE 00051899A PE 20000725 A1 PE20000725 A1 PE 20000725A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
het
alcoxypyrrolidinone
preferred
Prior art date
Application number
PE1999000518A
Other languages
English (en)
Inventor
Andrew D Gribble
Ashley E Fenwick
Marquis
Jason Witherington
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Smithkline Beecham Corp filed Critical Smithkline Beecham Plc
Publication of PE20000725A1 publication Critical patent/PE20000725A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)

Abstract

SE REFIERE A COMPUESTOS ALCOXIPIRROLIDINONA DE FORMULA I, DONDE X ES O, S, SO, SO2; Y ES H2, O; R1 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, (CH2)(0-6)CO2R", DE PREFERENCIA GRUPO a, b; R" ES H, ALQUILO C1-C6, ALQUENILO C2-C6, Ar-ALQUILO C0-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, HET-ALQUILO C0-C6, DE PREFERENCIA ISOBUTILO, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, DE PREFERENCIA GRUPO c, d; Ar ES FENILO, NAFTILO, OPCIONALMENTE SUSTITUIDO CON Ph-ALQUILO C0-C6, HET-ALQUILO C0-C6, O(CH2)(1-6)NR`R', ENTRE OTROS; R' ES H, ALQUILO C1-C6, ENTRE OTROS; HET ES UN ANILLO HETEROCICLICO BICICLICO DE 7-10 MIEMBROS, ANILLO MONICICLICO DE 5-7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON OR', N(R')2, SR'CF3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 3-BENCILOXI-1-(N-CARBOBENCILOXI-L-LEUCINIL)PIRROLIDIN-4-ONA, 1-[2-(BENCILOXICARBONILAMINO)-4-METILPENTIL]-3-BENCILTIO-4-HIDROXIPIRROLIDINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA CONVERTIR 3-BENCILOXI-4-HIDROXI-1-(N-CARBOBENCILOXI-L-LEUCINIL)PIRROLIDONA, ENTRE OTROS EN UN COMPUESTO DE FORMULA I. EL COMPUESTO I ES UN INHIBIDOR DE CISTEINA-PROTEASAS (CATEPSINA K) POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON UNA EXCESIVA DEGRADACION DE HUESO O CARTILAGO COMO OSTEOPOROSIS, PERIODONTITIS, ARTRITIS, ENFERMEDAD GINGIVAL O PERIODONTAL
PE1999000518A 1998-06-12 1999-06-11 Compuestos de alcoxipirrolidinona como inhibidores de proteasas PE20000725A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8905698P 1998-06-12 1998-06-12

Publications (1)

Publication Number Publication Date
PE20000725A1 true PE20000725A1 (es) 2000-09-28

Family

ID=22215426

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000518A PE20000725A1 (es) 1998-06-12 1999-06-11 Compuestos de alcoxipirrolidinona como inhibidores de proteasas

Country Status (10)

Country Link
EP (1) EP1086083A4 (es)
JP (1) JP2002517485A (es)
AR (1) AR018652A1 (es)
AU (1) AU4564499A (es)
CA (1) CA2334652A1 (es)
CO (1) CO5040090A1 (es)
DZ (1) DZ2815A1 (es)
MA (1) MA24877A1 (es)
PE (1) PE20000725A1 (es)
WO (1) WO1999064399A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
US6534498B1 (en) 1999-11-10 2003-03-18 Smithkline Beecham Corporation Protease inhibitors
JP2003513972A (ja) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテアーゼ阻害剤
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EA005893B1 (ru) 2000-03-21 2005-06-30 Смитклайн Бичам Корпорейшн Ингибиторы протеаз
US20020156063A1 (en) * 2001-04-06 2002-10-24 Setti Eduardo L. Arylacetamido-ketobenzoxazole as cysteine protease inhibitors
WO2003062192A1 (en) 2002-01-17 2003-07-31 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
EP2240491B1 (en) 2008-01-09 2015-07-15 Amura Therapeutics Limited TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES
CN117940420A (zh) 2021-09-14 2024-04-26 勃林格殷格翰国际有限公司 3-苯氧基氮杂环丁烷-1-基-杂芳基吡咯烷衍生物及其作为药物的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175218A1 (en) * 1993-11-09 1995-05-18 Gregori J. Morriello Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US5770573A (en) * 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase

Also Published As

Publication number Publication date
AR018652A1 (es) 2001-11-28
DZ2815A1 (fr) 2003-12-01
CO5040090A1 (es) 2001-05-29
MA24877A1 (fr) 1999-12-31
WO1999064399A1 (en) 1999-12-16
EP1086083A4 (en) 2001-09-26
EP1086083A1 (en) 2001-03-28
JP2002517485A (ja) 2002-06-18
AU4564499A (en) 1999-12-30
CA2334652A1 (en) 1999-12-16

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