PE20001237A1 - Inhibidores de proteasas - Google Patents

Inhibidores de proteasas

Info

Publication number
PE20001237A1
PE20001237A1 PE1999001145A PE00114599A PE20001237A1 PE 20001237 A1 PE20001237 A1 PE 20001237A1 PE 1999001145 A PE1999001145 A PE 1999001145A PE 00114599 A PE00114599 A PE 00114599A PE 20001237 A1 PE20001237 A1 PE 20001237A1
Authority
PE
Peru
Prior art keywords
compound
protease inhibitors
disease
morpholinoetoxi
ilcarbonil
Prior art date
Application number
PE1999001145A
Other languages
English (en)
Inventor
Andrew D Gribble
Jason Witherington
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PE20001237A1 publication Critical patent/PE20001237A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO MORFOLINO ETOXI BENZOFURANO DE FORMULA I, DONDE n ES 1-2, SIENDO UN COMPUESTO PREFERIDO: 4-(R)-AMINO-N-[[5-(2-N-MORFOLINOETOXI)-BENZO[b]FURAN-2-ILCARBONIL]-S-LEUCINA]-TETRAHIDROPIRAN-3-ONA. EL COMPUESTO I INHIBE A LA CISTEINA PROTEASA COMO CATEPSINA K; POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE LA OSTEOPOROSIS, ENFERMEDAD GINGIVAL, PERIODONTAL O ENFERMEDAD CARACTERIZADA POR UNA EXCESIVA DEGRADACION DE LOS CARTILAGOS O LAS MATRICES, OSTEOARTRITIS, ARTRITIS REUMATOIDE
PE1999001145A 1998-11-13 1999-11-12 Inhibidores de proteasas PE20001237A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10841098P 1998-11-13 1998-11-13

Publications (1)

Publication Number Publication Date
PE20001237A1 true PE20001237A1 (es) 2000-12-23

Family

ID=22322023

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001145A PE20001237A1 (es) 1998-11-13 1999-11-12 Inhibidores de proteasas

Country Status (5)

Country Link
AR (1) AR021241A1 (es)
AU (1) AU1393900A (es)
CO (1) CO5150165A1 (es)
PE (1) PE20001237A1 (es)
WO (1) WO2000029408A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EP1229914A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp PROTEASE INHIBITORS
WO2001034600A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
NZ520588A (en) 2000-03-21 2004-06-25 Smithkline Beecham Corp Protease inhibitors
JP2004520439A (ja) * 2000-11-17 2004-07-08 メディヴィル・アクチボラグ システインプロテアーゼインヒビター
JP2004522738A (ja) * 2001-01-17 2004-07-29 アミュラ テラピューティクス リミテッド クルジパインおよび他のシステインプロテアーゼの阻害剤としての環状２−カルボニルアミノケトン
US7132449B2 (en) 2001-01-17 2006-11-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
NZ526912A (en) * 2001-01-17 2005-02-25 Amura Therapeutics Ltd Inhibitors of cruzipain and other cysteine proteases
AU2002219397B2 (en) 2001-01-17 2008-02-14 Grünenthal GmbH Inhibitors of cruzipain and other cysteine proteases
WO2003062192A1 (en) 2002-01-17 2003-07-31 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
EP2240491B1 (en) 2008-01-09 2015-07-15 Amura Therapeutics Limited TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
CA2111930A1 (en) * 1992-12-25 1994-06-26 Ryoichi Ando Aminoketone derivatives
MA26487A1 (fr) * 1997-04-29 2004-12-20 Smithkline Beecham Corp Heterocyclecetohydrazides inhibiteurs de proteases, procede pour leur preparation et compositions pharmaceutiques les contenant .
AR013079A1 (es) * 1997-05-06 2000-12-13 Smithkline Beecham Corp Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios
EP0983228A4 (en) * 1997-05-08 2002-08-07 Smithkline Beecham Corp PROTEASE INHIBITORS
US6369077B1 (en) * 1997-05-08 2002-04-09 Smithkline Beecham Corporation Protease inhibitors
MA26618A1 (fr) * 1998-04-09 2004-12-20 Smithkline Beecham Corp Composes et compositions pharmaceutiques pour le traitement du paludisme
MA26631A1 (fr) * 1998-05-21 2004-12-20 Smithkline Beecham Corp Composes a fonction bis-aminomethyl-carbonyle nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
WO2000029408A1 (en) 2000-05-25
CO5150165A1 (es) 2002-04-29
AU1393900A (en) 2000-06-05
AR021241A1 (es) 2002-07-03

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Legal Events

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