PE20000065A1 - Combinaciones de inhibidor de ace-inhibidor de mmp - Google Patents
Combinaciones de inhibidor de ace-inhibidor de mmpInfo
- Publication number
- PE20000065A1 PE20000065A1 PE1998001267A PE00126798A PE20000065A1 PE 20000065 A1 PE20000065 A1 PE 20000065A1 PE 1998001267 A PE1998001267 A PE 1998001267A PE 00126798 A PE00126798 A PE 00126798A PE 20000065 A1 PE20000065 A1 PE 20000065A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitor
- cardiac valve
- tempylapril
- ace
- valve flexibility
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE a)UN INHIBIDOR DE ENZIMA CONVERTIDORA DE ANGIOTENSINA (ACE) TAL COMO CAPTOPRIL, ENALAPRIL, ENALPRILAT, LISINOPRIL, RAMIPRIL, ZOFENOPRIL, TRANDOLAPRIL, TEMOCAPRIL, CERANAPIL, ALACEPRIL, DELAPRIL, PENTOPRIL, QUINAPRIL, QUINAPRILAT, MOEXIPRIL, RENTIAPRIL, DUINAPRIL, SPIRAPRIL, CILAZAPRIL, PERINDOPRIL, FOSINOPRIL; b)UN INHIBIDOR DE METALOPROTEASA DE MATRIZ TAL COMO 4-(4`-CLOROBIFENIL-4-IL)-4-HIDROXIMINO-BUTIRICO, ACIDO 2-(4'-BROMOBIFENIL-4-SULFONILAMINO)-3- METIL-BUTIRICO O UN COMPUESTO DE FORMULA I, DONDE A ES FENILO, GRUPO a; Y ES CH o N; R1 ES ALQUILO, ARILO, HALO, AMINO OPCIONALMENTE SUSTITUIDO, ALCOXI; R2 ES CARBOXIALQUILCETONA U OXIMA, CARBOXIALQUILSULFONAMIDA. LA COMPOSICION TIENE EFECTO DE RETARDAR Y REVERTIR EL PROCESO DE FIBROSIS, DILATACION VENTRICULAR, INSUFICIENCIA CARDIACA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE FIBROSIS CARDIOVASCULAR, CARDIOMIOPATIA DILATADA, ESCLEROSIS DE VALVULAS CARDIACAS, FIBROSIS DE VALVULAS CARDIACAS, ENFERMEDAD CARDIACA REUMATICA, TRASTORNOS ARTERIOSCLEROTICOS, FIBROSIS PULMONAR, SINDROME DE FATIGA RESPIRATORIA DE ADULTOS, TRASTORNOS INFLAMATORIOS, ESPONDILITIS ANQUILOSANTE, GLOMERULO ESCLEROSIS, ADHERENCIAS DEL PERITONEO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6859497P | 1997-12-23 | 1997-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000065A1 true PE20000065A1 (es) | 2000-02-11 |
Family
ID=22083543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998001267A PE20000065A1 (es) | 1997-12-23 | 1998-12-22 | Combinaciones de inhibidor de ace-inhibidor de mmp |
Country Status (24)
Country | Link |
---|---|
US (1) | US6133304A (es) |
EP (1) | EP1047450B1 (es) |
JP (1) | JP2001526245A (es) |
KR (1) | KR20010033473A (es) |
AR (1) | AR015504A1 (es) |
AT (1) | ATE225187T1 (es) |
AU (1) | AU751701B2 (es) |
BR (1) | BR9814422A (es) |
CA (1) | CA2305436A1 (es) |
CO (1) | CO4970775A1 (es) |
DE (1) | DE69808518T2 (es) |
DK (1) | DK1047450T3 (es) |
ES (1) | ES2184340T3 (es) |
HU (1) | HUP0100427A3 (es) |
IL (1) | IL135428A0 (es) |
IS (1) | IS5446A (es) |
NO (1) | NO20003256D0 (es) |
NZ (1) | NZ503962A (es) |
PE (1) | PE20000065A1 (es) |
PL (1) | PL341335A1 (es) |
PT (1) | PT1047450E (es) |
UY (1) | UY25321A1 (es) |
WO (1) | WO1999032150A1 (es) |
ZA (1) | ZA9811794B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01008857A (es) * | 1999-03-03 | 2002-07-02 | Procter & Gamble | Inhibidores de metaloproteasa dihetero sustituidos. |
US6376524B1 (en) | 2000-06-21 | 2002-04-23 | Sunesis Pharmaceuticals, Inc. | Triphenyl compounds as interleukin-4 antagonists |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
KR100854424B1 (ko) | 2001-01-29 | 2008-08-27 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 치환된 인돌 및 인테그린 길항제로서의 이들의 용도 |
DE10125882B4 (de) * | 2001-05-28 | 2007-03-29 | Esparma Gmbh | Arzneimittel enthaltend Ambroxol, dessen Salze und/oder Prodrugs zusammen mit α-Liponsäure im Rahmen der Behandlung des Diabetes mellitus |
KR20040027920A (ko) * | 2001-08-20 | 2004-04-01 | 오노 야꾸힝 고교 가부시키가이샤 | 심부전 치료제 |
US7071211B2 (en) * | 2002-09-27 | 2006-07-04 | Bausch & Lomb Inc. | Small organic molecules that increase the activity of gelatinase a in ocular cells |
WO2004032708A2 (en) * | 2002-10-04 | 2004-04-22 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Vasoregulating compounds and methods of their use |
AU2003295422B2 (en) * | 2002-11-07 | 2009-01-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A new target for angiogenesis and anti-angiogenesis therapy |
JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
CA2534352A1 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
JP2007511539A (ja) * | 2003-11-14 | 2007-05-10 | バクスター・インターナショナル・インコーポレイテッド | α1−抗トリプシン組成物およびこのような組成物を用いた処置方法 |
JP2007528409A (ja) | 2004-03-09 | 2007-10-11 | アリバ ファーマシューティカルズ, インコーポレイテッド | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
US20080269282A1 (en) * | 2004-08-02 | 2008-10-30 | Genmedica Therapeutics Sl | Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof |
CN100367956C (zh) * | 2006-08-29 | 2008-02-13 | 陈俊云 | 用于治疗高血压的药物 |
JP2011525194A (ja) * | 2008-06-20 | 2011-09-15 | キネメッド, インコーポレイテッド | 線維性疾患または病態を治療するための組成物 |
WO2010011302A1 (en) * | 2008-07-22 | 2010-01-28 | Chdi, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
CN102639134A (zh) * | 2009-10-01 | 2012-08-15 | 和谐进化股份有限公司 | 使用基质金属蛋白酶-2抑制剂治疗动脉瘤样扩张、血管壁薄弱、特别是腹主动脉瘤和胸主动脉瘤的方法 |
MX2014002459A (es) | 2011-08-30 | 2014-04-10 | Chdi Foundation Inc | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos. |
EP3243515B1 (en) | 2011-08-30 | 2019-10-16 | CHDI Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
WO2014210062A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods for the regulation of matrix metalloproteinase expression |
US10258621B2 (en) | 2014-07-17 | 2019-04-16 | Chdi Foundation, Inc. | Methods and compositions for treating HIV-related disorders |
US20190008828A1 (en) | 2015-12-28 | 2019-01-10 | The U.S.A., As Represented By The Secretary Department Of Health And Human Services | Methods for inhibiting human immunodeficiency virus (hiv) release from infected cells |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0729938B2 (ja) * | 1990-05-11 | 1995-04-05 | フアイザー・インコーポレイテツド | 相乗的治療用組成物及び方法 |
CA2212713A1 (en) * | 1995-02-10 | 1996-08-15 | G.D. Searle & Co. | Combination of angiotensin converting enzyme inhibitor and side-effect-reduced amount of aldosterone antagonist |
KR20000011095A (ko) * | 1996-05-17 | 2000-02-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 비페닐술폰아미드 매트릭스 메탈로프로테이나아제 억제제 |
US5756545A (en) * | 1997-04-21 | 1998-05-26 | Warner-Lambert Company | Biphenysulfonamide matrix metal alloproteinase inhibitors |
-
1998
- 1998-11-10 DE DE69808518T patent/DE69808518T2/de not_active Expired - Fee Related
- 1998-11-10 AU AU15220/99A patent/AU751701B2/en not_active Ceased
- 1998-11-10 BR BR9814422-7A patent/BR9814422A/pt not_active IP Right Cessation
- 1998-11-10 WO PCT/US1998/023993 patent/WO1999032150A1/en not_active Application Discontinuation
- 1998-11-10 JP JP2000525140A patent/JP2001526245A/ja active Pending
- 1998-11-10 US US09/485,253 patent/US6133304A/en not_active Expired - Fee Related
- 1998-11-10 AT AT98959416T patent/ATE225187T1/de not_active IP Right Cessation
- 1998-11-10 PL PL98341335A patent/PL341335A1/xx unknown
- 1998-11-10 CA CA002305436A patent/CA2305436A1/en not_active Abandoned
- 1998-11-10 PT PT98959416T patent/PT1047450E/pt unknown
- 1998-11-10 IL IL13542898A patent/IL135428A0/xx unknown
- 1998-11-10 EP EP98959416A patent/EP1047450B1/en not_active Expired - Lifetime
- 1998-11-10 DK DK98959416T patent/DK1047450T3/da active
- 1998-11-10 ES ES98959416T patent/ES2184340T3/es not_active Expired - Lifetime
- 1998-11-10 NZ NZ503962A patent/NZ503962A/xx unknown
- 1998-11-10 HU HU0100427A patent/HUP0100427A3/hu unknown
- 1998-11-10 KR KR1020007006974A patent/KR20010033473A/ko not_active Application Discontinuation
- 1998-12-22 CO CO98076095A patent/CO4970775A1/es unknown
- 1998-12-22 ZA ZA9811794A patent/ZA9811794B/xx unknown
- 1998-12-22 UY UY25321A patent/UY25321A1/es unknown
- 1998-12-22 PE PE1998001267A patent/PE20000065A1/es not_active Application Discontinuation
- 1998-12-22 AR ARP980106613A patent/AR015504A1/es not_active Application Discontinuation
-
2000
- 2000-04-14 IS IS5446A patent/IS5446A/is unknown
- 2000-06-22 NO NO20003256A patent/NO20003256D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA9811794B (en) | 1999-06-29 |
EP1047450B1 (en) | 2002-10-02 |
AU1522099A (en) | 1999-07-12 |
CO4970775A1 (es) | 2000-11-07 |
KR20010033473A (ko) | 2001-04-25 |
IS5446A (is) | 2000-04-14 |
UY25321A1 (es) | 2004-07-30 |
BR9814422A (pt) | 2000-10-10 |
PL341335A1 (en) | 2001-04-09 |
DE69808518T2 (de) | 2003-06-26 |
AR015504A1 (es) | 2001-05-02 |
NO20003256L (no) | 2000-06-22 |
DK1047450T3 (da) | 2003-01-27 |
US6133304A (en) | 2000-10-17 |
EP1047450A1 (en) | 2000-11-02 |
CA2305436A1 (en) | 1999-07-01 |
DE69808518D1 (de) | 2002-11-07 |
HUP0100427A3 (en) | 2002-11-28 |
PT1047450E (pt) | 2003-02-28 |
NZ503962A (en) | 2002-03-28 |
ATE225187T1 (de) | 2002-10-15 |
AU751701B2 (en) | 2002-08-22 |
HUP0100427A2 (hu) | 2001-06-28 |
JP2001526245A (ja) | 2001-12-18 |
ES2184340T3 (es) | 2003-04-01 |
NO20003256D0 (no) | 2000-06-22 |
WO1999032150A1 (en) | 1999-07-01 |
IL135428A0 (en) | 2001-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |