PE17499A1 - Alquilacion reductiva de antibioticos glicopeptidos - Google Patents

Alquilacion reductiva de antibioticos glicopeptidos

Info

Publication number
PE17499A1
PE17499A1 PE1997001054A PE00105497A PE17499A1 PE 17499 A1 PE17499 A1 PE 17499A1 PE 1997001054 A PE1997001054 A PE 1997001054A PE 00105497 A PE00105497 A PE 00105497A PE 17499 A1 PE17499 A1 PE 17499A1
Authority
PE
Peru
Prior art keywords
glycopeptide
copper
rental
reductive
bencil
Prior art date
Application number
PE1997001054A
Other languages
English (en)
Inventor
Richard Alan Berglund
Howard Eugene Magadanz
Hua Zheng
Nancy Anne Lockwood
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE17499A1 publication Critical patent/PE17499A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

CARACTERIZADO PORQUE COMPRENDE: PREPARAR IN SITU UN COMPUESTO DE COBRE SOLUBLE DEL ANTIBIOTICO GLICOPEPTIDO DEL TIPO DE LA VANCOMICINA A PARTIR DE UNA FORMA SOLUBLE DE COBRE TAL COMO ACETATO DE COBRE (III) Y DE DICHO GLICOPEPTIDO A UN pH � 4; HACER REACCIONAR EL COMPUESTO DE COBRE DEL GLICOPEPTIDO CON UNA CETONA O ALDEHIDO QUE ES 4`-CLORO-4-BIFENILCARBOXALDEHIDO, EN PRESENCIA DE UN AGENTE REDUCTOR QUE ES CIANOBOROHIDRURO SODICO O PIRIDINA-BORANO Y UN SOLVENTE COMO METANOL, OBTENIENDOSE UN COMPUESTO DE COBRE DEL GLICOPEPTIDO ALQUILADO; RECUPERAR EL ANTIBIOTICO GLICOPEPTIDO ALQUILADO, QUE PREFERENTEMENTE ES N4-(4-(4-CLOROFENIL)BENCIL A82846B. ESTE PROCEDIMIENTO ALQUILA SELECTIVAMENTE EN EL SITIO DE LA AMINA EN UN SACARIDO EN LA POSICION N4 EN EL ANTIBIOTICO GLICOPEPTIDO, MEJORANDO LA ACTIVIDAD ANTIBACTERIANA DEL GLICOPEPTIDO
PE1997001054A 1996-11-21 1997-11-19 Alquilacion reductiva de antibioticos glicopeptidos PE17499A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3159696P 1996-11-21 1996-11-21

Publications (1)

Publication Number Publication Date
PE17499A1 true PE17499A1 (es) 1999-02-19

Family

ID=21860369

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997001054A PE17499A1 (es) 1996-11-21 1997-11-19 Alquilacion reductiva de antibioticos glicopeptidos

Country Status (28)

Country Link
EP (1) EP0845478B1 (es)
JP (1) JP4308912B2 (es)
KR (1) KR100514276B1 (es)
CN (1) CN100463917C (es)
AR (1) AR010621A1 (es)
AT (1) ATE286910T1 (es)
AU (1) AU723941B2 (es)
BR (1) BR9713523B1 (es)
CA (1) CA2272240C (es)
CO (1) CO4650045A1 (es)
CZ (1) CZ300528B6 (es)
DE (1) DE69732215T2 (es)
EA (1) EA002925B1 (es)
EG (1) EG23855A (es)
HK (1) HK1011542A1 (es)
HU (1) HU227641B1 (es)
ID (1) ID18900A (es)
IL (1) IL129991A0 (es)
MY (1) MY117383A (es)
NO (1) NO325365B1 (es)
NZ (1) NZ335840A (es)
PE (1) PE17499A1 (es)
PL (1) PL190780B1 (es)
TR (1) TR199901679T2 (es)
TW (1) TW585868B (es)
UA (1) UA58526C2 (es)
WO (1) WO1998022121A1 (es)
ZA (1) ZA9710428B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60135102D1 (de) * 2000-05-02 2008-09-11 Theravance Inc Verfahren zur reduktiven alkylierung von glykopeptiden
MX2015011760A (es) 2013-03-15 2016-06-10 Melinta Therapeutics Inc Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos.
AU2015289602B2 (en) * 2014-07-17 2020-06-25 Abbvie Inc. High purity oritavancin and method of producing same
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051237A (en) * 1975-08-28 1977-09-27 Bristol-Myers Company Glycopeptide antibiotics bu-2231 a and b and process for producing same
JPS58116497A (ja) * 1981-12-29 1983-07-11 Microbial Chem Res Found アミノプロピルアミノブレオマイシン誘導体及びその製造法
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
NZ236393A (en) * 1989-12-13 1992-05-26 Lilly Co Eli N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions
MY128335A (en) * 1994-01-28 2007-01-31 Lilly Co Eli Glycopeptide antibiotic derivatives

Also Published As

Publication number Publication date
AU723941B2 (en) 2000-09-07
BR9713523A (pt) 2000-03-21
WO1998022121A1 (en) 1998-05-28
IL129991A0 (en) 2000-02-29
HK1011542A1 (en) 1999-07-16
CZ300528B6 (cs) 2009-06-10
JP4308912B2 (ja) 2009-08-05
CA2272240C (en) 2011-02-08
CA2272240A1 (en) 1998-05-28
AR010621A1 (es) 2000-06-28
DE69732215T2 (de) 2006-01-12
CZ179499A3 (cs) 2000-01-12
HUP0000268A3 (en) 2001-04-28
NZ335840A (en) 2000-09-29
TW585868B (en) 2004-05-01
KR20000057156A (ko) 2000-09-15
CN100463917C (zh) 2009-02-25
EP0845478A1 (en) 1998-06-03
AU5449798A (en) 1998-06-10
JP2001504494A (ja) 2001-04-03
CO4650045A1 (es) 1998-09-03
KR100514276B1 (ko) 2005-09-13
EG23855A (en) 2007-11-11
UA58526C2 (uk) 2003-08-15
NO325365B1 (no) 2008-04-14
EA002925B1 (ru) 2002-10-31
ZA9710428B (en) 1999-05-19
PL190780B1 (pl) 2006-01-31
DE69732215D1 (de) 2005-02-17
HU227641B1 (en) 2011-10-28
NO992415L (no) 1999-05-20
EP0845478B1 (en) 2005-01-12
ID18900A (id) 1998-05-20
EA199900480A1 (ru) 2000-02-28
CN1244802A (zh) 2000-02-16
ATE286910T1 (de) 2005-01-15
TR199901679T2 (xx) 1999-09-21
NO992415D0 (no) 1999-05-20
MY117383A (en) 2004-06-30
BR9713523B1 (pt) 2010-07-27
HUP0000268A2 (hu) 2000-08-28

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed