PE17499A1 - Alquilacion reductiva de antibioticos glicopeptidos - Google Patents
Alquilacion reductiva de antibioticos glicopeptidosInfo
- Publication number
- PE17499A1 PE17499A1 PE1997001054A PE00105497A PE17499A1 PE 17499 A1 PE17499 A1 PE 17499A1 PE 1997001054 A PE1997001054 A PE 1997001054A PE 00105497 A PE00105497 A PE 00105497A PE 17499 A1 PE17499 A1 PE 17499A1
- Authority
- PE
- Peru
- Prior art keywords
- glycopeptide
- copper
- rental
- reductive
- bencil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
CARACTERIZADO PORQUE COMPRENDE: PREPARAR IN SITU UN COMPUESTO DE COBRE SOLUBLE DEL ANTIBIOTICO GLICOPEPTIDO DEL TIPO DE LA VANCOMICINA A PARTIR DE UNA FORMA SOLUBLE DE COBRE TAL COMO ACETATO DE COBRE (III) Y DE DICHO GLICOPEPTIDO A UN pH � 4; HACER REACCIONAR EL COMPUESTO DE COBRE DEL GLICOPEPTIDO CON UNA CETONA O ALDEHIDO QUE ES 4`-CLORO-4-BIFENILCARBOXALDEHIDO, EN PRESENCIA DE UN AGENTE REDUCTOR QUE ES CIANOBOROHIDRURO SODICO O PIRIDINA-BORANO Y UN SOLVENTE COMO METANOL, OBTENIENDOSE UN COMPUESTO DE COBRE DEL GLICOPEPTIDO ALQUILADO; RECUPERAR EL ANTIBIOTICO GLICOPEPTIDO ALQUILADO, QUE PREFERENTEMENTE ES N4-(4-(4-CLOROFENIL)BENCIL A82846B. ESTE PROCEDIMIENTO ALQUILA SELECTIVAMENTE EN EL SITIO DE LA AMINA EN UN SACARIDO EN LA POSICION N4 EN EL ANTIBIOTICO GLICOPEPTIDO, MEJORANDO LA ACTIVIDAD ANTIBACTERIANA DEL GLICOPEPTIDO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3159696P | 1996-11-21 | 1996-11-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE17499A1 true PE17499A1 (es) | 1999-02-19 |
Family
ID=21860369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997001054A PE17499A1 (es) | 1996-11-21 | 1997-11-19 | Alquilacion reductiva de antibioticos glicopeptidos |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0845478B1 (es) |
JP (1) | JP4308912B2 (es) |
KR (1) | KR100514276B1 (es) |
CN (1) | CN100463917C (es) |
AR (1) | AR010621A1 (es) |
AT (1) | ATE286910T1 (es) |
AU (1) | AU723941B2 (es) |
BR (1) | BR9713523B1 (es) |
CA (1) | CA2272240C (es) |
CO (1) | CO4650045A1 (es) |
CZ (1) | CZ300528B6 (es) |
DE (1) | DE69732215T2 (es) |
EA (1) | EA002925B1 (es) |
EG (1) | EG23855A (es) |
HK (1) | HK1011542A1 (es) |
HU (1) | HU227641B1 (es) |
ID (1) | ID18900A (es) |
IL (1) | IL129991A0 (es) |
MY (1) | MY117383A (es) |
NO (1) | NO325365B1 (es) |
NZ (1) | NZ335840A (es) |
PE (1) | PE17499A1 (es) |
PL (1) | PL190780B1 (es) |
TR (1) | TR199901679T2 (es) |
TW (1) | TW585868B (es) |
UA (1) | UA58526C2 (es) |
WO (1) | WO1998022121A1 (es) |
ZA (1) | ZA9710428B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60135102D1 (de) * | 2000-05-02 | 2008-09-11 | Theravance Inc | Verfahren zur reduktiven alkylierung von glykopeptiden |
MX2015011760A (es) | 2013-03-15 | 2016-06-10 | Melinta Therapeutics Inc | Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos. |
AU2015289602B2 (en) * | 2014-07-17 | 2020-06-25 | Abbvie Inc. | High purity oritavancin and method of producing same |
CN106188243B (zh) * | 2015-05-05 | 2020-06-26 | 博瑞生物医药(苏州)股份有限公司 | 一种奥利万星的制备方法 |
CN106467570B (zh) * | 2015-08-14 | 2020-04-07 | 正大天晴药业集团股份有限公司 | 糖肽类抗生素的还原烷基化方法 |
CN108409837B (zh) * | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4051237A (en) * | 1975-08-28 | 1977-09-27 | Bristol-Myers Company | Glycopeptide antibiotics bu-2231 a and b and process for producing same |
JPS58116497A (ja) * | 1981-12-29 | 1983-07-11 | Microbial Chem Res Found | アミノプロピルアミノブレオマイシン誘導体及びその製造法 |
US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
NZ236393A (en) * | 1989-12-13 | 1992-05-26 | Lilly Co Eli | N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions |
MY128335A (en) * | 1994-01-28 | 2007-01-31 | Lilly Co Eli | Glycopeptide antibiotic derivatives |
-
1997
- 1997-11-13 ID IDP973669A patent/ID18900A/id unknown
- 1997-11-19 AR ARP970105411A patent/AR010621A1/es active IP Right Grant
- 1997-11-19 AT AT97309305T patent/ATE286910T1/de not_active IP Right Cessation
- 1997-11-19 CO CO97067572A patent/CO4650045A1/es unknown
- 1997-11-19 MY MYPI97005545A patent/MY117383A/en unknown
- 1997-11-19 ZA ZA9710428A patent/ZA9710428B/xx unknown
- 1997-11-19 DE DE69732215T patent/DE69732215T2/de not_active Expired - Lifetime
- 1997-11-19 EP EP97309305A patent/EP0845478B1/en not_active Expired - Lifetime
- 1997-11-19 PE PE1997001054A patent/PE17499A1/es not_active Application Discontinuation
- 1997-11-19 EG EG123597A patent/EG23855A/xx active
- 1997-11-20 IL IL12999197A patent/IL129991A0/xx not_active IP Right Cessation
- 1997-11-20 WO PCT/US1997/021238 patent/WO1998022121A1/en active IP Right Grant
- 1997-11-20 CZ CZ0179499A patent/CZ300528B6/cs not_active IP Right Cessation
- 1997-11-20 UA UA99052810A patent/UA58526C2/uk unknown
- 1997-11-20 TR TR1999/01679T patent/TR199901679T2/xx unknown
- 1997-11-20 AU AU54497/98A patent/AU723941B2/en not_active Ceased
- 1997-11-20 JP JP52387898A patent/JP4308912B2/ja not_active Expired - Fee Related
- 1997-11-20 NZ NZ335840A patent/NZ335840A/xx not_active IP Right Cessation
- 1997-11-20 EA EA199900480A patent/EA002925B1/ru not_active IP Right Cessation
- 1997-11-20 KR KR10-1999-7004441A patent/KR100514276B1/ko not_active IP Right Cessation
- 1997-11-20 HU HU0000268A patent/HU227641B1/hu not_active IP Right Cessation
- 1997-11-20 CA CA2272240A patent/CA2272240C/en not_active Expired - Fee Related
- 1997-11-20 PL PL333778A patent/PL190780B1/pl unknown
- 1997-11-20 BR BRPI9713523-2A patent/BR9713523B1/pt not_active IP Right Cessation
- 1997-11-20 CN CNB971813701A patent/CN100463917C/zh not_active Expired - Fee Related
- 1997-11-22 TW TW086117372A patent/TW585868B/zh not_active IP Right Cessation
-
1998
- 1998-12-03 HK HK98112780A patent/HK1011542A1/xx not_active IP Right Cessation
-
1999
- 1999-05-20 NO NO19992415A patent/NO325365B1/no not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |