BR9713523A - Alquilação redutora de antibióticos glicopeptìdicos - Google Patents

Alquilação redutora de antibióticos glicopeptìdicos

Info

Publication number
BR9713523A
BR9713523A BR9713523A BR9713523A BR9713523A BR 9713523 A BR9713523 A BR 9713523A BR 9713523 A BR9713523 A BR 9713523A BR 9713523 A BR9713523 A BR 9713523A BR 9713523 A BR9713523 A BR 9713523A
Authority
BR
Brazil
Prior art keywords
glycopeptide antibiotics
alkylation
reductive alkylation
glycopeptide
complex
Prior art date
Application number
BR9713523A
Other languages
English (en)
Other versions
BR9713523B1 (pt
Inventor
Richard A Berglund
Nancy A Lockwood
Howard E Magadanz
Hua Zheng
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9713523A publication Critical patent/BR9713523A/pt
Publication of BR9713523B1 publication Critical patent/BR9713523B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

IBIóTICOS GLICOPEPTìDICOS"<D>. Esta invenção refere-se a processos melhorados para alquilação redutora de antibióticos glicopeptídicos. Sendo a melhorue resulta na produção inicial de um compleo de cobre do antibiótico glicopeptídico. A alquilação redutora deste complexo favorece a alquilação regiosseletiva e rendimentos aumentados. São também parte da invenção os materiais de partida dos complexos de cobre do antibiótico glicopeptídico e dos produtos alquilados.
BRPI9713523-2A 1996-11-21 1997-11-20 processo para alquilar redutivamente um antibiótico glicopeptìdico compreendendo um sacarìdeo contendo uma amina em n4 e uma ou outras mais aminas. BR9713523B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3159696P 1996-11-21 1996-11-21
PCT/US1997/021238 WO1998022121A1 (en) 1996-11-21 1997-11-20 Reductive alkylation of glycopeptide antibiotics

Publications (2)

Publication Number Publication Date
BR9713523A true BR9713523A (pt) 2000-03-21
BR9713523B1 BR9713523B1 (pt) 2010-07-27

Family

ID=21860369

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9713523-2A BR9713523B1 (pt) 1996-11-21 1997-11-20 processo para alquilar redutivamente um antibiótico glicopeptìdico compreendendo um sacarìdeo contendo uma amina em n4 e uma ou outras mais aminas.

Country Status (28)

Country Link
EP (1) EP0845478B1 (pt)
JP (1) JP4308912B2 (pt)
KR (1) KR100514276B1 (pt)
CN (1) CN100463917C (pt)
AR (1) AR010621A1 (pt)
AT (1) ATE286910T1 (pt)
AU (1) AU723941B2 (pt)
BR (1) BR9713523B1 (pt)
CA (1) CA2272240C (pt)
CO (1) CO4650045A1 (pt)
CZ (1) CZ300528B6 (pt)
DE (1) DE69732215T2 (pt)
EA (1) EA002925B1 (pt)
EG (1) EG23855A (pt)
HK (1) HK1011542A1 (pt)
HU (1) HU227641B1 (pt)
ID (1) ID18900A (pt)
IL (1) IL129991A0 (pt)
MY (1) MY117383A (pt)
NO (1) NO325365B1 (pt)
NZ (1) NZ335840A (pt)
PE (1) PE17499A1 (pt)
PL (1) PL190780B1 (pt)
TR (1) TR199901679T2 (pt)
TW (1) TW585868B (pt)
UA (1) UA58526C2 (pt)
WO (1) WO1998022121A1 (pt)
ZA (1) ZA9710428B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6831150B2 (en) * 2000-05-02 2004-12-14 Theravance, Inc. Reductive alkylation process
EP2969004A4 (en) 2013-03-15 2016-09-21 Melinta Therapeutics Inc METHOD FOR THE TREATMENT OF INFECTIONS IN OVERWEIGHT AND ADIPOSIVE PATIENTS USING ANTIBIOTICS
WO2016011245A1 (en) * 2014-07-17 2016-01-21 The Medicines Company High purity oritavancin and method of producing same
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051237A (en) * 1975-08-28 1977-09-27 Bristol-Myers Company Glycopeptide antibiotics bu-2231 a and b and process for producing same
JPS58116497A (ja) * 1981-12-29 1983-07-11 Microbial Chem Res Found アミノプロピルアミノブレオマイシン誘導体及びその製造法
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
NZ236393A (en) * 1989-12-13 1992-05-26 Lilly Co Eli N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions
TW457248B (en) * 1994-01-28 2001-10-01 Lilly Co Eli Glycopeptide antibiotic derivatives

Also Published As

Publication number Publication date
CN1244802A (zh) 2000-02-16
HUP0000268A2 (hu) 2000-08-28
CN100463917C (zh) 2009-02-25
CZ179499A3 (cs) 2000-01-12
HU227641B1 (en) 2011-10-28
EA199900480A1 (ru) 2000-02-28
NO992415L (no) 1999-05-20
HUP0000268A3 (en) 2001-04-28
WO1998022121A1 (en) 1998-05-28
ZA9710428B (en) 1999-05-19
DE69732215D1 (de) 2005-02-17
JP4308912B2 (ja) 2009-08-05
KR20000057156A (ko) 2000-09-15
EA002925B1 (ru) 2002-10-31
EG23855A (en) 2007-11-11
AR010621A1 (es) 2000-06-28
AU5449798A (en) 1998-06-10
TW585868B (en) 2004-05-01
ATE286910T1 (de) 2005-01-15
TR199901679T2 (xx) 1999-09-21
CO4650045A1 (es) 1998-09-03
KR100514276B1 (ko) 2005-09-13
ID18900A (id) 1998-05-20
EP0845478A1 (en) 1998-06-03
HK1011542A1 (en) 1999-07-16
NO325365B1 (no) 2008-04-14
CZ300528B6 (cs) 2009-06-10
BR9713523B1 (pt) 2010-07-27
PL190780B1 (pl) 2006-01-31
IL129991A0 (en) 2000-02-29
PE17499A1 (es) 1999-02-19
UA58526C2 (uk) 2003-08-15
NO992415D0 (no) 1999-05-20
JP2001504494A (ja) 2001-04-03
CA2272240C (en) 2011-02-08
AU723941B2 (en) 2000-09-07
DE69732215T2 (de) 2006-01-12
EP0845478B1 (en) 2005-01-12
NZ335840A (en) 2000-09-29
MY117383A (en) 2004-06-30
CA2272240A1 (en) 1998-05-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/07/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 27.07.2020