PA8436501A1 - Ligandos espirociclicos de un subtipo de receptor de la dopamina. - Google Patents
Ligandos espirociclicos de un subtipo de receptor de la dopamina.Info
- Publication number
- PA8436501A1 PA8436501A1 PA19978436501A PA8436501A PA8436501A1 PA 8436501 A1 PA8436501 A1 PA 8436501A1 PA 19978436501 A PA19978436501 A PA 19978436501A PA 8436501 A PA8436501 A PA 8436501A PA 8436501 A1 PA8436501 A1 PA 8436501A1
- Authority
- PA
- Panama
- Prior art keywords
- spyrocyclic
- leagues
- dopamine receptor
- receptor subtype
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
ESTA INVENCION SE REFIERE A NUEVOS COMPUESTOS FARMACEUTICAMENTE ACTIVOS DE FORMULA 1 EN LA QUE A, B Y R1 A R6 SON COMO SE HAN DEFINIDO EN LA MEMORIA. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD DOPAMINERGICA CENTRAL Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2479796P | 1996-08-26 | 1996-08-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8436501A1 true PA8436501A1 (es) | 2000-05-24 |
Family
ID=21822443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA19978436501A PA8436501A1 (es) | 1996-08-26 | 1997-08-22 | Ligandos espirociclicos de un subtipo de receptor de la dopamina. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6664258B1 (es) |
EP (1) | EP0925291B1 (es) |
JP (1) | JP3152941B2 (es) |
AP (1) | AP9701075A0 (es) |
AR (1) | AR013836A1 (es) |
AT (1) | ATE311377T1 (es) |
AU (1) | AU3632297A (es) |
CA (1) | CA2264549C (es) |
CO (1) | CO4560554A1 (es) |
DE (1) | DE69734774D1 (es) |
GT (1) | GT199700096A (es) |
HN (1) | HN1997000117A (es) |
HR (1) | HRP970455A2 (es) |
ID (1) | ID18076A (es) |
IL (1) | IL128050A0 (es) |
IS (1) | IS4969A (es) |
MA (1) | MA26437A1 (es) |
PA (1) | PA8436501A1 (es) |
PE (1) | PE108498A1 (es) |
TN (1) | TNSN97143A1 (es) |
WO (1) | WO1998008835A1 (es) |
ZA (1) | ZA977597B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0953567A3 (en) | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
AU754529B2 (en) * | 1998-09-22 | 2002-11-21 | Yamanouchi Pharmaceutical Co., Ltd. | Cyanophenyl derivatives |
EP1177792A3 (en) * | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
GB0328906D0 (en) | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
EP2780015B1 (en) | 2011-11-18 | 2017-01-04 | Heptares Therapeutics Limited | Muscarinic m1 receptor agonists |
GB201617454D0 (en) * | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE758919A (fr) * | 1969-11-15 | 1971-05-13 | Merck Patent Gmbh | Spiro-composes |
US3932425A (en) * | 1974-04-12 | 1976-01-13 | The Upjohn Company | Benzospiran derivatives |
US4025558A (en) * | 1974-04-12 | 1977-05-24 | The Upjohn Company | Organic compounds |
US4010201A (en) * | 1974-04-12 | 1977-03-01 | The Upjohn Company | Organic compounds |
DE2818329A1 (de) * | 1978-04-26 | 1979-11-08 | Yoshitomi Pharmaceutical | Spiro eckige klammer auf cyclohexan- 1,9'-thioxanthen eckige klammer zu -verbindungen |
CA2091204C (en) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Antiischemic-piperazinyl and piperidinyl-cyclohexanes |
CA2146019A1 (en) | 1992-10-23 | 1994-05-11 | Howard B. Broughton | Dopamine receptor subtype ligands |
GB9317631D0 (en) | 1993-08-25 | 1993-10-13 | Bxl Plastics Ltd | Multi-layered composite |
US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
WO1995030642A1 (en) * | 1994-05-06 | 1995-11-16 | Pharmacopeia, Inc. | Combinatorial dihydrobenzopyran library |
GB9410031D0 (en) | 1994-05-19 | 1994-07-06 | Merck Sharp & Dohme | Therapeutic agents |
-
1997
- 1997-08-08 EP EP97932964A patent/EP0925291B1/en not_active Expired - Lifetime
- 1997-08-08 JP JP51143198A patent/JP3152941B2/ja not_active Expired - Fee Related
- 1997-08-08 AU AU36322/97A patent/AU3632297A/en not_active Abandoned
- 1997-08-08 CA CA002264549A patent/CA2264549C/en not_active Expired - Fee Related
- 1997-08-08 AT AT97932964T patent/ATE311377T1/de not_active IP Right Cessation
- 1997-08-08 WO PCT/IB1997/000978 patent/WO1998008835A1/en active IP Right Grant
- 1997-08-08 US US09/242,819 patent/US6664258B1/en not_active Expired - Fee Related
- 1997-08-08 IL IL12805097A patent/IL128050A0/xx unknown
- 1997-08-08 DE DE69734774T patent/DE69734774D1/de not_active Expired - Lifetime
- 1997-08-12 HN HN1997000117A patent/HN1997000117A/es unknown
- 1997-08-19 PE PE1997000731A patent/PE108498A1/es not_active Application Discontinuation
- 1997-08-21 AP APAP/P/1997/001075A patent/AP9701075A0/en unknown
- 1997-08-22 AR ARP970103835A patent/AR013836A1/es unknown
- 1997-08-22 CO CO97048585A patent/CO4560554A1/es unknown
- 1997-08-22 PA PA19978436501A patent/PA8436501A1/es unknown
- 1997-08-22 HR HR60/024,797A patent/HRP970455A2/hr not_active Application Discontinuation
- 1997-08-25 ZA ZA977597A patent/ZA977597B/xx unknown
- 1997-08-25 MA MA24775A patent/MA26437A1/fr unknown
- 1997-08-25 ID IDP972950A patent/ID18076A/id unknown
- 1997-08-25 GT GT199700096A patent/GT199700096A/es unknown
- 1997-08-25 TN TNTNSN97143A patent/TNSN97143A1/fr unknown
-
1999
- 1999-02-05 IS IS4969A patent/IS4969A/is unknown
Also Published As
Publication number | Publication date |
---|---|
CA2264549C (en) | 2004-09-14 |
ZA977597B (en) | 1999-02-25 |
TNSN97143A1 (fr) | 2005-03-15 |
EP0925291B1 (en) | 2005-11-30 |
WO1998008835A1 (en) | 1998-03-05 |
ATE311377T1 (de) | 2005-12-15 |
CO4560554A1 (es) | 1998-02-10 |
PE108498A1 (es) | 1999-01-29 |
HRP970455A2 (en) | 1998-08-31 |
DE69734774D1 (de) | 2006-01-05 |
AP9701075A0 (en) | 1997-10-31 |
EP0925291A1 (en) | 1999-06-30 |
JP2000502360A (ja) | 2000-02-29 |
ID18076A (id) | 1998-02-26 |
HN1997000117A (es) | 1997-12-26 |
GT199700096A (es) | 1999-02-16 |
CA2264549A1 (en) | 1998-03-05 |
US6664258B1 (en) | 2003-12-16 |
MA26437A1 (fr) | 2004-12-20 |
IL128050A0 (en) | 1999-11-30 |
AR013836A1 (es) | 2001-01-31 |
IS4969A (is) | 1999-02-05 |
AU3632297A (en) | 1998-03-19 |
JP3152941B2 (ja) | 2001-04-03 |
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