CO4560554A1 - Ligandos espirociclicos de un subtipo de receptor de la do- pamina - Google Patents

Ligandos espirociclicos de un subtipo de receptor de la do- pamina

Info

Publication number
CO4560554A1
CO4560554A1 CO97048585A CO97048585A CO4560554A1 CO 4560554 A1 CO4560554 A1 CO 4560554A1 CO 97048585 A CO97048585 A CO 97048585A CO 97048585 A CO97048585 A CO 97048585A CO 4560554 A1 CO4560554 A1 CO 4560554A1
Authority
CO
Colombia
Prior art keywords
spyrocyclic
pamina
leagues
receptor subtype
sulfur
Prior art date
Application number
CO97048585A
Other languages
English (en)
Inventor
Todd William Butler
Anton Franz Joseph Fliri
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO4560554A1 publication Critical patent/CO4560554A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1. UN COMPUESTO DE FORMULA I. VER FORMULA I EN LA QUE a ESOXIGENO, CH2, C(CH3)2,NR^10, AZUFRE SO O S02; b ES OXIGENO, CH2,C=O, C=NR^11, C+NOH, SO2, AZUFRE SO,C=NO-ALQUILO C1-C5 O CR^7R^8; CADA UNO DE LOS R^1 A LOS R^8 SE SELECCIONAN, INDEPENDIENTEMENTE, ENTRE HIDROGENO, HALO (POR EJEMPLO, CLORO, FLUORO, BROMO O YODO), TRIFUORME- TILO, CIANO, HIDROXI, R^7 Y R^8 O JUNTOS PUEDEN SER C(=O)NH2 O C(=O)N- ALQUILO C1-C4, CON LA CONDICION DE QUE nI R^7 NI R^8 PUEDEN SER HALO CUANDO A ES OXIGENO, NR^11, AZUFRE,SO,O SO2; Y CADA UNO DE R^10 Y R^11 SE SELECCIONAN INDEPEN- DIENTE, ENTRE HIDROGENO, BENCILO Y ALQUILO C1-C6; Y LAS SALES FARMACEUTICAMENTE ACPETABLES DE DICHOS COMPUESTOS.
CO97048585A 1996-08-26 1997-08-22 Ligandos espirociclicos de un subtipo de receptor de la do- pamina CO4560554A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2479796P 1996-08-26 1996-08-26

Publications (1)

Publication Number Publication Date
CO4560554A1 true CO4560554A1 (es) 1998-02-10

Family

ID=21822443

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97048585A CO4560554A1 (es) 1996-08-26 1997-08-22 Ligandos espirociclicos de un subtipo de receptor de la do- pamina

Country Status (22)

Country Link
US (1) US6664258B1 (es)
EP (1) EP0925291B1 (es)
JP (1) JP3152941B2 (es)
AP (1) AP9701075A0 (es)
AR (1) AR013836A1 (es)
AT (1) ATE311377T1 (es)
AU (1) AU3632297A (es)
CA (1) CA2264549C (es)
CO (1) CO4560554A1 (es)
DE (1) DE69734774D1 (es)
GT (1) GT199700096A (es)
HN (1) HN1997000117A (es)
HR (1) HRP970455A2 (es)
ID (1) ID18076A (es)
IL (1) IL128050A0 (es)
IS (1) IS4969A (es)
MA (1) MA26437A1 (es)
PA (1) PA8436501A1 (es)
PE (1) PE108498A1 (es)
TN (1) TNSN97143A1 (es)
WO (1) WO1998008835A1 (es)
ZA (1) ZA977597B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0953567A3 (en) 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
AU754529B2 (en) * 1998-09-22 2002-11-21 Yamanouchi Pharmaceutical Co., Ltd. Cyanophenyl derivatives
EP1177792A3 (en) * 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
GB0328906D0 (en) 2003-12-12 2004-01-14 Syngenta Participations Ag Chemical compounds
CN106831541B (zh) 2011-11-18 2019-09-06 赫普泰雅治疗有限公司 毒蕈碱性m1受体激动剂
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201617454D0 (en) * 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758919A (fr) 1969-11-15 1971-05-13 Merck Patent Gmbh Spiro-composes
US3932425A (en) 1974-04-12 1976-01-13 The Upjohn Company Benzospiran derivatives
US4010201A (en) 1974-04-12 1977-03-01 The Upjohn Company Organic compounds
US4025558A (en) 1974-04-12 1977-05-24 The Upjohn Company Organic compounds
DE2818329A1 (de) 1978-04-26 1979-11-08 Yoshitomi Pharmaceutical Spiro eckige klammer auf cyclohexan- 1,9'-thioxanthen eckige klammer zu -verbindungen
CA2091204C (en) 1992-03-11 1997-04-08 Ronald J. Mattson Antiischemic-piperazinyl and piperidinyl-cyclohexanes
ES2133416T3 (es) 1992-10-23 1999-09-16 Merck Sharp & Dohme Ligandos de subtipos de receptores de dopamina.
GB9317631D0 (en) 1993-08-25 1993-10-13 Bxl Plastics Ltd Multi-layered composite
US5403846A (en) 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
AU691296B2 (en) 1994-05-06 1998-05-14 Pharmacopeia Drug Discovery, Inc. Combinatorial dihydrobenzopyran library
GB9410031D0 (en) 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
HN1997000117A (es) 1997-12-26
IL128050A0 (en) 1999-11-30
WO1998008835A1 (en) 1998-03-05
HRP970455A2 (en) 1998-08-31
JP2000502360A (ja) 2000-02-29
US6664258B1 (en) 2003-12-16
DE69734774D1 (de) 2006-01-05
PE108498A1 (es) 1999-01-29
PA8436501A1 (es) 2000-05-24
GT199700096A (es) 1999-02-16
AR013836A1 (es) 2001-01-31
AU3632297A (en) 1998-03-19
CA2264549C (en) 2004-09-14
IS4969A (is) 1999-02-05
EP0925291B1 (en) 2005-11-30
AP9701075A0 (en) 1997-10-31
ID18076A (id) 1998-02-26
MA26437A1 (fr) 2004-12-20
ZA977597B (en) 1999-02-25
ATE311377T1 (de) 2005-12-15
TNSN97143A1 (fr) 2005-03-15
EP0925291A1 (en) 1999-06-30
JP3152941B2 (ja) 2001-04-03
CA2264549A1 (en) 1998-03-05

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