CO4970752A1 - Nuevos derivados de isatin y composiciones farmaceuticas conteniendo tales isatines - Google Patents

Nuevos derivados de isatin y composiciones farmaceuticas conteniendo tales isatines

Info

Publication number
CO4970752A1
CO4970752A1 CO98043133A CO98043133A CO4970752A1 CO 4970752 A1 CO4970752 A1 CO 4970752A1 CO 98043133 A CO98043133 A CO 98043133A CO 98043133 A CO98043133 A CO 98043133A CO 4970752 A1 CO4970752 A1 CO 4970752A1
Authority
CO
Colombia
Prior art keywords
isatin
sulfonyl
alkyl
isatin5
sulfo
Prior art date
Application number
CO98043133A
Other languages
English (en)
Inventor
Dennis Lee
Scott Allen Long
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO4970752A1 publication Critical patent/CO4970752A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de fórmula:en la que:R1 es hidrógeno o alquilo C1 -C4 ;R2 alquilo C1 -C10 , aril-alquilo C1 -C4 opcionalmente sustituido, heteroaril-alquilo C1 -C4 opcionalmente sustituido, cicloalquilo C3 -C7 opcionalmente sustituido, o R1 y R2 junto con el nitrógeno al que están unidos forman un anillo de 3 a 10 miembros que contiene opcionalmente un heteroátomo adicional seleccionado entre oxígeno,nitrógeno o azufre;R3 y R4 son alquilo C1 -C6 , hidrógeno, nitro o halógeno y R5 es alquilo C1 -C6 , hidrógeno, arilalquilo o heteroarilalquilo.El compuesto según la reivindicación 1, que es:(S)-(+)-5-[1-(2-Metoximetilpirrolidinil)sulfonil]- isatina DL-5-[1-(2-Hidroxietil)piperidinil)sulfonil]isatina(+/-)-5-[1-(3-Hidroximetil)piperidinil)sulfonil]isa-tina (S)-(+)-5-[1-(2-Hidroximetilpirrolidinil)sulfonil]-isatina(S)-(+)-5-[1-(2-Benciloxicarbonilpirrolidinil)sulfo-nil]isatina 5-[N-(N-Metil-2-hidroxietilamino)sulfonil]isatina5-[N-(N-Metil-2-(4-piridin)etilamino)sulfonil]isatina5-[N-(N´-Bencilpiperazin)sulfonil]isatina(R)-(-)-5-[1-(2-Metoximetilpirrolidinil)sulfonil]-isatina (S)-(+)-5-[1-(2-Metoxicarbonilpirrolidinil)sulfo-nil]isatina5-[N-(N-Metilanilino)sulfonil]isatina(S)-(+)-5-[1-(2-t-Butoxicarbonilpirrolidinil)sulfo-nil]isatina - 2 -
CO98043133A 1997-07-30 1998-07-29 Nuevos derivados de isatin y composiciones farmaceuticas conteniendo tales isatines CO4970752A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5425597P 1997-07-30 1997-07-30

Publications (1)

Publication Number Publication Date
CO4970752A1 true CO4970752A1 (es) 2000-11-07

Family

ID=21989796

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98043133A CO4970752A1 (es) 1997-07-30 1998-07-29 Nuevos derivados de isatin y composiciones farmaceuticas conteniendo tales isatines

Country Status (10)

Country Link
US (1) US6403792B1 (es)
EP (1) EP1001933A4 (es)
JP (1) JP2001512100A (es)
AR (1) AR016384A1 (es)
AU (1) AU8763298A (es)
CA (1) CA2297757A1 (es)
CO (1) CO4970752A1 (es)
IL (1) IL132770A0 (es)
WO (1) WO1999006367A1 (es)
ZA (1) ZA986760B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR016551A1 (es) * 1997-07-30 2001-07-25 Smithkline Beecham Corp Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos
EP1104754A1 (en) * 1998-08-11 2001-06-06 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives
JP2003510278A (ja) * 1999-09-30 2003-03-18 スミスクライン・ビーチャム・コーポレイション カスパーゼおよびアポプトシス
WO2001045716A1 (en) * 1999-12-20 2001-06-28 Gho'st Holding B.V. Pharmaceutical composition comprising a physiologically acceptable vanadium compound, salt or complex and a na+/h+ exchange inhibitor
AU2001262711A1 (en) * 2000-06-08 2001-12-17 Mitsubishi Pharma Corporation Cytoprotectors
SE0004780D0 (sv) 2000-12-22 2000-12-22 Jordanian Pharmaceutical Mfg & Novel compunds
AT413485B (de) * 2001-04-09 2006-03-15 Hemoteq Gmbh Mit einem pharmazeutikum beschichteter stent
US7009053B2 (en) 2002-04-30 2006-03-07 Yungjin Pharmaceuticals Co., Ltd. Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same
GB0327494D0 (en) * 2003-11-26 2003-12-31 Amersham Plc Novel imaging agents
US7256198B2 (en) 2004-02-18 2007-08-14 Wyeth Pyrimidoindolones and methods for using same
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
WO2009051244A1 (ja) * 2007-10-18 2009-04-23 Takeda Pharmaceutical Company Limited 複素環化合物
AU2009289062B2 (en) 2008-09-05 2015-01-22 Hammersmith Imanet Limited Isatin derivatives for use as in vivo imaging agents
HRP20171415T4 (hr) * 2009-06-25 2023-03-03 Alkermes Pharma Ireland Limited Heterociklični spojevi za liječenje neuroloških i psiholoških poremećaja
EP2563761A1 (en) 2010-04-29 2013-03-06 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
CA2850707C (en) 2011-10-03 2023-03-21 The University Of Utah Research Foundation Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome
CN103183631B (zh) * 2011-12-28 2016-08-24 天津市国际生物医药联合研究院 靛红-5-磺酰胺类衍生物及其在制备治疗非典型性肺炎的药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE715760C (de) * 1938-12-02 1942-01-07 Ig Farbenindustrie Ag Verfahren zur Herstellung von Sulfonamiden der Indolreihe
MC1357A1 (fr) 1979-12-07 1981-08-10 Hoffmann La Roche Derives de 2,3-indoledione
SE434638B (sv) * 1980-06-06 1984-08-06 Lekemedelsfabriken Medica Ab Nya terapeutiska verdefulla taurinderivat och deras framstellning
US5164404A (en) * 1991-03-15 1992-11-17 Neurosearch A/S Hydrazone derivatives and their use
AU655643B2 (en) * 1991-07-09 1995-01-05 Neurosearch A/S Novel isatineoxime derivatives, their preparation and use
AU5772196A (en) * 1995-05-19 1996-11-29 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use

Also Published As

Publication number Publication date
EP1001933A4 (en) 2002-11-06
AU8763298A (en) 1999-02-22
WO1999006367A1 (en) 1999-02-11
US6403792B1 (en) 2002-06-11
ZA986760B (en) 1999-02-01
AR016384A1 (es) 2001-07-04
JP2001512100A (ja) 2001-08-21
EP1001933A1 (en) 2000-05-24
IL132770A0 (en) 2001-03-19
CA2297757A1 (en) 1999-02-11

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