ATE311377T1 - Spirocyclische dopaminrezeptor-subtyp-liganden - Google Patents
Spirocyclische dopaminrezeptor-subtyp-ligandenInfo
- Publication number
- ATE311377T1 ATE311377T1 AT97932964T AT97932964T ATE311377T1 AT E311377 T1 ATE311377 T1 AT E311377T1 AT 97932964 T AT97932964 T AT 97932964T AT 97932964 T AT97932964 T AT 97932964T AT E311377 T1 ATE311377 T1 AT E311377T1
- Authority
- AT
- Austria
- Prior art keywords
- spirocyclic
- dopamine receptor
- receptor subtype
- subtype ligands
- ligands
- Prior art date
Links
- 102000015554 Dopamine receptor Human genes 0.000 title 1
- 108050004812 Dopamine receptor Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2479796P | 1996-08-26 | 1996-08-26 | |
| PCT/IB1997/000978 WO1998008835A1 (en) | 1996-08-26 | 1997-08-08 | Spirocyclic dopamine receptor subtype ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE311377T1 true ATE311377T1 (de) | 2005-12-15 |
Family
ID=21822443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97932964T ATE311377T1 (de) | 1996-08-26 | 1997-08-08 | Spirocyclische dopaminrezeptor-subtyp-liganden |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6664258B1 (de) |
| EP (1) | EP0925291B1 (de) |
| JP (1) | JP3152941B2 (de) |
| AP (1) | AP9701075A0 (de) |
| AR (1) | AR013836A1 (de) |
| AT (1) | ATE311377T1 (de) |
| AU (1) | AU3632297A (de) |
| CA (1) | CA2264549C (de) |
| CO (1) | CO4560554A1 (de) |
| DE (1) | DE69734774D1 (de) |
| GT (1) | GT199700096A (de) |
| HN (1) | HN1997000117A (de) |
| HR (1) | HRP970455A2 (de) |
| ID (1) | ID18076A (de) |
| IL (1) | IL128050A0 (de) |
| IS (1) | IS4969A (de) |
| MA (1) | MA26437A1 (de) |
| PA (1) | PA8436501A1 (de) |
| PE (1) | PE108498A1 (de) |
| TN (1) | TNSN97143A1 (de) |
| WO (1) | WO1998008835A1 (de) |
| ZA (1) | ZA977597B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0953567A3 (de) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bizyklisch substituierte Piperazin-, Piperidin- und Tetrahydropyridin Derivate, deren Herstellung und deren Verwendung als Mittel mit zentraler dopaminerger (Dopamin D4 Rezeptor) Aktivität |
| WO2000017163A1 (fr) * | 1998-09-22 | 2000-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Derives de cyanophenyle |
| EP1177792A3 (de) * | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamin-d4-ligande zur behandlung von gaudi-suchenden krankheiten |
| GB0328906D0 (en) | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
| JP6083818B2 (ja) | 2011-11-18 | 2017-02-22 | ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | ムスカリンｍ１受容体アゴニスト |
| GB201404922D0 (en) | 2014-03-19 | 2014-04-30 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201617454D0 (en) * | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819961D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758919A (fr) * | 1969-11-15 | 1971-05-13 | Merck Patent Gmbh | Spiro-composes |
| US3932425A (en) * | 1974-04-12 | 1976-01-13 | The Upjohn Company | Benzospiran derivatives |
| US4010201A (en) * | 1974-04-12 | 1977-03-01 | The Upjohn Company | Organic compounds |
| US4025558A (en) * | 1974-04-12 | 1977-05-24 | The Upjohn Company | Organic compounds |
| DE2818329A1 (de) * | 1978-04-26 | 1979-11-08 | Yoshitomi Pharmaceutical | Spiro eckige klammer auf cyclohexan- 1,9'-thioxanthen eckige klammer zu -verbindungen |
| CA2091204C (en) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Antiischemic-piperazinyl and piperidinyl-cyclohexanes |
| ES2133416T3 (es) | 1992-10-23 | 1999-09-16 | Merck Sharp & Dohme | Ligandos de subtipos de receptores de dopamina. |
| GB9317631D0 (en) | 1993-08-25 | 1993-10-13 | Bxl Plastics Ltd | Multi-layered composite |
| US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
| AU691296B2 (en) * | 1994-05-06 | 1998-05-14 | Pharmacopeia Drug Discovery, Inc. | Combinatorial dihydrobenzopyran library |
| GB9410031D0 (en) | 1994-05-19 | 1994-07-06 | Merck Sharp & Dohme | Therapeutic agents |
-
1997
- 1997-08-08 WO PCT/IB1997/000978 patent/WO1998008835A1/en active IP Right Grant
- 1997-08-08 DE DE69734774T patent/DE69734774D1/de not_active Expired - Lifetime
- 1997-08-08 EP EP97932964A patent/EP0925291B1/de not_active Expired - Lifetime
- 1997-08-08 JP JP51143198A patent/JP3152941B2/ja not_active Expired - Fee Related
- 1997-08-08 IL IL12805097A patent/IL128050A0/xx unknown
- 1997-08-08 US US09/242,819 patent/US6664258B1/en not_active Expired - Fee Related
- 1997-08-08 AU AU36322/97A patent/AU3632297A/en not_active Abandoned
- 1997-08-08 CA CA002264549A patent/CA2264549C/en not_active Expired - Fee Related
- 1997-08-08 AT AT97932964T patent/ATE311377T1/de not_active IP Right Cessation
- 1997-08-12 HN HN1997000117A patent/HN1997000117A/es unknown
- 1997-08-19 PE PE1997000731A patent/PE108498A1/es not_active Application Discontinuation
- 1997-08-21 AP APAP/P/1997/001075A patent/AP9701075A0/en unknown
- 1997-08-22 HR HR60/024,797A patent/HRP970455A2/hr not_active Application Discontinuation
- 1997-08-22 PA PA19978436501A patent/PA8436501A1/es unknown
- 1997-08-22 AR ARP970103835A patent/AR013836A1/es unknown
- 1997-08-22 CO CO97048585A patent/CO4560554A1/es unknown
- 1997-08-25 ID IDP972950A patent/ID18076A/id unknown
- 1997-08-25 ZA ZA977597A patent/ZA977597B/xx unknown
- 1997-08-25 TN TNTNSN97143A patent/TNSN97143A1/fr unknown
- 1997-08-25 MA MA24775A patent/MA26437A1/fr unknown
- 1997-08-25 GT GT199700096A patent/GT199700096A/es unknown
-
1999
- 1999-02-05 IS IS4969A patent/IS4969A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2264549C (en) | 2004-09-14 |
| EP0925291B1 (de) | 2005-11-30 |
| CO4560554A1 (es) | 1998-02-10 |
| ZA977597B (en) | 1999-02-25 |
| PA8436501A1 (es) | 2000-05-24 |
| JP2000502360A (ja) | 2000-02-29 |
| AP9701075A0 (en) | 1997-10-31 |
| AR013836A1 (es) | 2001-01-31 |
| US6664258B1 (en) | 2003-12-16 |
| JP3152941B2 (ja) | 2001-04-03 |
| HN1997000117A (es) | 1997-12-26 |
| AU3632297A (en) | 1998-03-19 |
| EP0925291A1 (de) | 1999-06-30 |
| WO1998008835A1 (en) | 1998-03-05 |
| ID18076A (id) | 1998-02-26 |
| GT199700096A (es) | 1999-02-16 |
| DE69734774D1 (de) | 2006-01-05 |
| PE108498A1 (es) | 1999-01-29 |
| TNSN97143A1 (fr) | 2005-03-15 |
| IL128050A0 (en) | 1999-11-30 |
| HRP970455A2 (en) | 1998-08-31 |
| MA26437A1 (fr) | 2004-12-20 |
| IS4969A (is) | 1999-02-05 |
| CA2264549A1 (en) | 1998-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |