PE20020505A1 - Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades - Google Patents
Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedadesInfo
- Publication number
- PE20020505A1 PE20020505A1 PE2001000834A PE2001000834A PE20020505A1 PE 20020505 A1 PE20020505 A1 PE 20020505A1 PE 2001000834 A PE2001000834 A PE 2001000834A PE 2001000834 A PE2001000834 A PE 2001000834A PE 20020505 A1 PE20020505 A1 PE 20020505A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- rent
- carboxamide
- oct
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I DONDE R1 ES H, ALQUILO, CICLOALQUILO, ALQUILO HALOGENADO, ARILO; R2 ES H, ALQUILO, ALQUILO HALOGENADO, ALQUILO SUSTITUIDO, CICLOALQUILO, BENCILO, ENTRE OTROS; W ES EL GRUPO a ENTRE OTROS DONDE V E Y SON =N, =C(R5)-; Z ES =N, =CH- Y CON LA CONDICION DE QUE CUANDO V E Y SEAN AMBOS =C(R5)- Y Z ES =CH, SOLAMENTE UN =C(R5)- PUEDE SER =CH- Y CON LA CONDICION ADICIONAL DE QUE CUANDO U ES O, Y ES =C(R5)- Y Z ES =C(R5)-, V NO PUEDE SER =N-; R3 ES H, ALQUILO, CICLOALQUILO, HETEROCICLOALQUILO, ALQUILO HALOGENADO, CICLOALQUILO HALOGENADO, ENTRE OTROS; R5 ES H, ALQUILO, ALQUENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-5-FENIL-TIOFEN-2-CARBOXAMIDA, N[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-5-(4-CLOROFENIL)-TIOFEN-2-CARBOXAMIDA, N[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-5-(3-CLOROFENIL)-TIOFEN-2-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS ACTUAN SOBRE LOS RECEPTORES DE LA ACETILCOLINA O7 NICOTINICOS Y REGULA LA ACTIVIDAD DEL SISTEMA NERVIOSO CENTRAL
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22665200P | 2000-08-21 | 2000-08-21 | |
US28483201P | 2001-04-19 | 2001-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020505A1 true PE20020505A1 (es) | 2002-06-12 |
Family
ID=26920741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000834A PE20020505A1 (es) | 2000-08-21 | 2001-08-21 | Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1311505A2 (es) |
JP (1) | JP2004506734A (es) |
AU (1) | AU2001282910A1 (es) |
PE (1) | PE20020505A1 (es) |
WO (1) | WO2002016355A2 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
NZ533259A (en) | 2001-12-14 | 2007-10-26 | Targacept Inc | Methods and compositions for treatment of central nervous system disorders |
DE10211416A1 (de) * | 2002-03-15 | 2003-09-25 | Bayer Ag | Essig- und Propionsäureamide |
DE10211415A1 (de) * | 2002-03-15 | 2003-09-25 | Bayer Ag | Bicyclische N-Biarylamide |
DE10234424A1 (de) * | 2002-07-29 | 2004-02-12 | Bayer Ag | Benzothiophen-, Benzofuran- und Indolharnstoffe |
AU2003283648A1 (en) * | 2002-12-06 | 2004-06-30 | Pharmacia & Upjohn Company Llc | Compounds as radioligands for the diagnosis of disease |
EP1587511A2 (en) * | 2003-01-22 | 2005-10-26 | Pharmacia & Upjohn Company LLC | Treatment of diseases with alpha-7 nach receptor full agonists |
AU2004282201A1 (en) | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
SE0303076D0 (sv) * | 2003-11-19 | 2003-11-19 | Astrazeneca Ab | 5-substituted imidazoles |
SE0303075D0 (sv) * | 2003-11-19 | 2003-11-19 | Astrazeneca Ab | 4-substituted imidazoles |
BRPI0417933A (pt) * | 2003-12-22 | 2007-04-17 | Astrazeneca Ab | composto, métodos para o tratamento ou a profilaxia de uma doença ou condição, e de distúrbios, e para a indução da cessação do hábito de fumar, composição farmacêutica, e, uso de um composto |
KR20060125812A (ko) * | 2003-12-22 | 2006-12-06 | 아스트라제네카 아베 | 니코틴성 아세틸콜린 수용체 리간드 |
JP2007538046A (ja) | 2004-05-19 | 2007-12-27 | ノイロサーチ アクティーゼルスカブ | 新規なアザビシクロアリール誘導体 |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
US7732607B2 (en) | 2005-08-22 | 2010-06-08 | Anatoly Mazurov | Heteroaryl-substituted diazatricycloalkanes and methods of use thereof |
SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
MX2010002258A (es) | 2007-08-27 | 2010-04-22 | Helicon Therapeutics Inc | Compuestos terapeuticos de isoxazol. |
CA2701126A1 (en) | 2007-10-01 | 2009-04-09 | Comentis, Inc. | 4-substituted quinuclidine derivatives, methods of production, and pharmaceutical uses thereof |
WO2009098282A1 (en) * | 2008-02-06 | 2009-08-13 | Novasaid Ab | Low molecular weight 2,5-disubstituted thiophene derivatives and use thereof in therapy |
RS52941B (en) | 2008-02-13 | 2014-02-28 | Targacept Inc. | A COMBINATION OF ALFA 7 NICOTINE AGONISTS AND ANTIPSYCHOTICS |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
EA024170B1 (ru) * | 2011-02-23 | 2016-08-31 | Люпин Лимитед | ГЕТЕРОАРИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ nAChR АЛЬФА7 |
WO2013005153A1 (en) * | 2011-07-05 | 2013-01-10 | Lupin Limited | Biaryl derivatives as nachr modulators |
JPWO2013161871A1 (ja) * | 2012-04-25 | 2015-12-24 | 興和株式会社 | Tlr阻害作用を有するチオフェン誘導体 |
JPWO2014069554A1 (ja) * | 2012-10-31 | 2016-09-08 | 東レ株式会社 | キヌクリジンアミド誘導体及びその医薬用途 |
EP3166940A4 (en) | 2014-07-11 | 2018-04-25 | Alpharmagen, LLC | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863919A (en) * | 1988-02-01 | 1989-09-05 | A. H. Robins Company, Incorporated | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
IT1228288B (it) * | 1989-01-09 | 1991-06-07 | Zambon Spa | Composti ad attivita' antiserotoninica |
JPH04247081A (ja) * | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | 5員複素環酸アミド類 |
SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
EP0984970B1 (en) * | 1997-05-30 | 2003-11-19 | Neurosearch A/S | Spiro-quinuclidine derivatives, their preparation and use |
SE9904176D0 (sv) * | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
SE0000540D0 (sv) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
-
2001
- 2001-08-17 EP EP01961664A patent/EP1311505A2/en not_active Withdrawn
- 2001-08-17 JP JP2002521456A patent/JP2004506734A/ja active Pending
- 2001-08-17 AU AU2001282910A patent/AU2001282910A1/en not_active Abandoned
- 2001-08-17 WO PCT/US2001/022597 patent/WO2002016355A2/en not_active Application Discontinuation
- 2001-08-21 PE PE2001000834A patent/PE20020505A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2004506734A (ja) | 2004-03-04 |
AU2001282910A1 (en) | 2002-03-04 |
EP1311505A2 (en) | 2003-05-21 |
WO2002016355A2 (en) | 2002-02-28 |
WO2002016355A3 (en) | 2002-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |