OA12134A - Novel substituted pyrazoloÄ4-3-eÜdiazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them. - Google Patents

Novel substituted pyrazoloÄ4-3-eÜdiazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them. Download PDF

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Publication number
OA12134A
OA12134A OA1200200203A OA1200200203A OA12134A OA 12134 A OA12134 A OA 12134A OA 1200200203 A OA1200200203 A OA 1200200203A OA 1200200203 A OA1200200203 A OA 1200200203A OA 12134 A OA12134 A OA 12134A
Authority
OA
OAPI
Prior art keywords
diazepin
pyrazolo
dihydro
ethyl
ppm
Prior art date
Application number
OA1200200203A
Other languages
English (en)
Inventor
Amaya Berecibar
Catherine Burnouf
Michel Navet
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of OA12134A publication Critical patent/OA12134A/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
OA1200200203A 2000-01-05 2000-12-27 Novel substituted pyrazoloÄ4-3-eÜdiazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them. OA12134A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0000095A FR2803299B1 (fr) 2000-01-05 2000-01-05 NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION

Publications (1)

Publication Number Publication Date
OA12134A true OA12134A (en) 2006-05-05

Family

ID=8845641

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200203A OA12134A (en) 2000-01-05 2000-12-27 Novel substituted pyrazoloÄ4-3-eÜdiazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them.

Country Status (42)

Country Link
EP (1) EP1248787B1 (es)
JP (1) JP2003519233A (es)
KR (1) KR20020063293A (es)
CN (1) CN1420888A (es)
AP (1) AP2002002572A0 (es)
AR (1) AR032298A1 (es)
AT (1) ATE278692T1 (es)
AU (1) AU3367801A (es)
BG (1) BG106893A (es)
BR (1) BR0016926A (es)
CA (1) CA2396315A1 (es)
CO (1) CO5290255A1 (es)
CR (1) CR6693A (es)
CZ (1) CZ20022222A3 (es)
DE (1) DE60014712T2 (es)
DZ (1) DZ3103A1 (es)
EA (1) EA005071B1 (es)
EE (1) EE200200373A (es)
ES (1) ES2226978T3 (es)
FR (1) FR2803299B1 (es)
GT (1) GT200100002A (es)
HK (1) HK1050002A1 (es)
HN (1) HN2001000002A (es)
HR (1) HRP20020577A2 (es)
HU (1) HUP0204213A2 (es)
IL (1) IL150394A0 (es)
IS (1) IS6437A (es)
MA (1) MA26863A1 (es)
MX (1) MXPA02006618A (es)
NO (1) NO20023249L (es)
NZ (1) NZ519520A (es)
OA (1) OA12134A (es)
PA (1) PA8509601A1 (es)
PE (1) PE20011041A1 (es)
PL (1) PL356668A1 (es)
SK (1) SK9402002A3 (es)
SV (1) SV2001000253A (es)
TN (1) TNSN01001A1 (es)
TR (1) TR200201719T2 (es)
UY (1) UY26517A1 (es)
WO (1) WO2001049689A2 (es)
ZA (1) ZA200205287B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
TW200745106A (en) * 2005-10-03 2007-12-16 Astrazeneca Ab Chemical compounds
KR20160080799A (ko) 2014-12-30 2016-07-08 한국해양과학기술원 금 촉매를 이용한 α-피론 유도체 전합성 방법 및 이에 의해 합성되어 인간 암세포주에 세포독성을 가지는 α-피론 유도체
EP3551632B1 (en) 2016-12-12 2024-06-12 UNION therapeutics A/S Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
US10906915B2 (en) 2016-12-12 2021-02-02 Leo Pharma A/S Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
DK3551634T3 (da) 2016-12-12 2021-06-14 Union Therapeutics As Substituerede pyrazoloazepin-8-oner og anvendelse deraf som phosphodiesterasehæmmere
TWI812739B (zh) * 2018-06-21 2023-08-21 景凱生物科技股份有限公司 Nadph氧化酶抑制劑、含其的醫藥組合物、及其應用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764688A (en) * 1972-07-27 1973-10-09 Abbott Lab 4,6-DIHYDRO-1,3-DIMETHYL-8-PHENYL-4-PROPARGYL-PYRAZOLO {8 4,3-e{9 {0 DIAZEPIN-5 (1H) ONE IN TREATING INFLAMMATION

Also Published As

Publication number Publication date
PL356668A1 (en) 2004-06-28
FR2803299A1 (fr) 2001-07-06
BR0016926A (pt) 2002-11-19
EP1248787B1 (en) 2004-10-06
GT200100002A (es) 2002-01-18
AR032298A1 (es) 2003-11-05
WO2001049689A3 (en) 2001-12-20
UY26517A1 (es) 2001-03-16
IS6437A (is) 2002-06-19
TR200201719T2 (tr) 2002-12-23
DE60014712T2 (de) 2006-02-02
CA2396315A1 (en) 2001-07-12
ZA200205287B (en) 2003-07-02
HN2001000002A (es) 2001-09-26
BG106893A (en) 2003-04-30
CN1420888A (zh) 2003-05-28
NO20023249D0 (no) 2002-07-04
NZ519520A (en) 2004-02-27
EE200200373A (et) 2003-10-15
PE20011041A1 (es) 2001-10-12
HK1050002A1 (zh) 2003-06-06
JP2003519233A (ja) 2003-06-17
CO5290255A1 (es) 2003-06-27
HRP20020577A2 (en) 2003-12-31
AP2002002572A0 (en) 2002-09-30
CR6693A (es) 2004-04-27
IL150394A0 (en) 2002-12-01
HUP0204213A2 (hu) 2003-04-28
KR20020063293A (ko) 2002-08-01
ES2226978T3 (es) 2005-04-01
AU3367801A (en) 2001-07-16
FR2803299B1 (fr) 2004-09-17
NO20023249L (no) 2002-09-04
DE60014712D1 (de) 2004-11-11
CZ20022222A3 (cs) 2003-05-14
SK9402002A3 (en) 2003-08-05
EA005071B1 (ru) 2004-10-28
TNSN01001A1 (fr) 2005-11-10
ATE278692T1 (de) 2004-10-15
MXPA02006618A (es) 2002-09-30
WO2001049689A2 (en) 2001-07-12
PA8509601A1 (es) 2002-07-30
DZ3103A1 (fr) 2004-06-20
SV2001000253A (es) 2001-10-16
MA26863A1 (fr) 2004-12-20
EA200200610A1 (ru) 2002-12-26
EP1248787A2 (en) 2002-10-16

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