DK3551634T3 - Substituerede pyrazoloazepin-8-oner og anvendelse deraf som phosphodiesterasehæmmere - Google Patents

Substituerede pyrazoloazepin-8-oner og anvendelse deraf som phosphodiesterasehæmmere Download PDF

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Publication number
DK3551634T3
DK3551634T3 DK16819452.0T DK16819452T DK3551634T3 DK 3551634 T3 DK3551634 T3 DK 3551634T3 DK 16819452 T DK16819452 T DK 16819452T DK 3551634 T3 DK3551634 T3 DK 3551634T3
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DK
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Prior art keywords
ones
phosphodiesterase inhibitors
pyrazoloazepin
substituted
substituted pyrazoloazepin
Prior art date
Application number
DK16819452.0T
Other languages
English (en)
Inventor
Xifu Liang
Jens Larsen
Original Assignee
Union Therapeutics As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Union Therapeutics As filed Critical Union Therapeutics As
Application granted granted Critical
Publication of DK3551634T3 publication Critical patent/DK3551634T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16819452.0T 2016-12-12 2016-12-12 Substituerede pyrazoloazepin-8-oner og anvendelse deraf som phosphodiesterasehæmmere DK3551634T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2016/080550 WO2018108231A1 (en) 2016-12-12 2016-12-12 Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
DK3551634T3 true DK3551634T3 (da) 2021-06-14

Family

ID=57680212

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16819452.0T DK3551634T3 (da) 2016-12-12 2016-12-12 Substituerede pyrazoloazepin-8-oner og anvendelse deraf som phosphodiesterasehæmmere

Country Status (8)

Country Link
US (1) US10793580B2 (da)
EP (1) EP3551634B1 (da)
JP (1) JP6850887B2 (da)
CN (1) CN110099905A (da)
DK (1) DK3551634T3 (da)
ES (1) ES2874632T3 (da)
RU (1) RU2764273C2 (da)
WO (1) WO2018108231A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2768746C2 (ru) * 2016-12-12 2022-03-24 Юнион Терапьютикс А/С Замещенные пиразолоазепин-4-оны и их применение в качестве ингибиторов фосфодиэстеразы
WO2019115776A1 (en) 2017-12-15 2019-06-20 Leo Pharma A/S Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2803299B1 (fr) 2000-01-05 2004-09-17 Warner Lambert Co NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
WO2004098520A2 (en) 2003-05-01 2004-11-18 Irm Llc Compounds and compositions as protein kinase inhibitors
TW200745106A (en) 2005-10-03 2007-12-16 Astrazeneca Ab Chemical compounds
CA2669886A1 (en) 2006-11-15 2008-05-22 Vertex Pharmaceuticals Incorporated Compounds useful as protein kinase inhibitors
RS53407B (en) * 2007-02-28 2014-10-31 Leo Pharma A/S NEW PHOSPHODIESTERASE INHIBITORS
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos

Also Published As

Publication number Publication date
JP6850887B2 (ja) 2021-03-31
US10793580B2 (en) 2020-10-06
RU2019121681A (ru) 2021-01-12
ES2874632T3 (es) 2021-11-05
CN110099905A (zh) 2019-08-06
WO2018108231A1 (en) 2018-06-21
EP3551634B1 (en) 2021-03-31
EP3551634A1 (en) 2019-10-16
JP2020500921A (ja) 2020-01-16
US20190330223A1 (en) 2019-10-31
RU2764273C2 (ru) 2022-01-17
RU2019121681A3 (da) 2021-01-12

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