OA11997A - Streptomyces avermitillis gene directing the ratioof B2:B1 avermectins. - Google Patents

Streptomyces avermitillis gene directing the ratioof B2:B1 avermectins. Download PDF

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Publication number
OA11997A
OA11997A OA1200200024A OA1200200024A OA11997A OA 11997 A OA11997 A OA 11997A OA 1200200024 A OA1200200024 A OA 1200200024A OA 1200200024 A OA1200200024 A OA 1200200024A OA 11997 A OA11997 A OA 11997A
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OA
OAPI
Prior art keywords
leu
ala
val
gly
arg
Prior art date
Application number
OA1200200024A
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English (en)
Inventor
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11997A publication Critical patent/OA11997A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
OA1200200024A 1999-08-12 2000-07-19 Streptomyces avermitillis gene directing the ratioof B2:B1 avermectins. OA11997A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/372,934 US6248579B1 (en) 1998-02-13 1999-08-12 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

Publications (1)

Publication Number Publication Date
OA11997A true OA11997A (en) 2006-04-18

Family

ID=23470234

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200024A OA11997A (en) 1999-08-12 2000-07-19 Streptomyces avermitillis gene directing the ratioof B2:B1 avermectins.

Country Status (37)

Country Link
US (8) US6248579B1 (es)
EP (1) EP1200605B1 (es)
JP (2) JP3688640B2 (es)
KR (1) KR100486006B1 (es)
CN (1) CN1186447C (es)
AP (2) AP2002002419A0 (es)
AR (1) AR021450A1 (es)
AT (1) ATE283363T1 (es)
AU (1) AU779756B2 (es)
BG (1) BG106478A (es)
BR (1) BR0013093A (es)
CA (1) CA2381427A1 (es)
CO (1) CO5290296A1 (es)
CZ (1) CZ2002297A3 (es)
DE (1) DE60016231T2 (es)
EA (1) EA004569B1 (es)
ES (1) ES2231214T3 (es)
GT (2) GT200000138CA (es)
HK (1) HK1046536B (es)
HR (1) HRP20020131A2 (es)
HU (1) HUP0202517A2 (es)
IL (1) IL147562A0 (es)
IS (1) IS6249A (es)
MA (1) MA26811A1 (es)
MX (1) MXPA02001514A (es)
NO (1) NO20020665D0 (es)
OA (1) OA11997A (es)
PA (1) PA8499201A1 (es)
PE (1) PE20010697A1 (es)
PL (1) PL353770A1 (es)
PT (1) PT1200605E (es)
SK (1) SK1382002A3 (es)
TN (1) TNSN00170A1 (es)
UY (1) UY26287A1 (es)
WO (1) WO2001012822A1 (es)
YU (1) YU8402A (es)
ZA (1) ZA200201071B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3884651B2 (ja) * 1999-08-12 2007-02-21 ファイザー・プロダクツ・インク Ｂ２アベルメクチン：ｂ１アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子
EP1474396B9 (en) 2002-02-05 2008-07-09 Bristol-Myers Squibb Company N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
MXPA04007777A (es) 2002-02-12 2004-10-15 Pfizer Prod Inc Gen de streptomyces avertmitilis que rige la relacion de avermectinas b2:b1.
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
EP1597271B1 (de) * 2003-01-31 2013-03-06 Max-Delbrück-Centrum Für Molekulare Medizin Peptide gegen kälteunverträglichkeit hervorrufende autoantikörper und ihre verwendung
KR100759130B1 (ko) 2005-02-12 2007-09-19 휴메드 주식회사 항 인테그린 항체 코팅스텐트 및 그의 제조방법
CN106148216B (zh) * 2015-03-27 2019-06-04 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a3的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
ES2054822T3 (es) 1987-10-23 1994-08-16 Pfizer Procedimiento para la produccion de agliconas de avermectinas y sus cultivos.
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
NZ233116A (en) 1989-03-31 1994-09-27 Merck & Co Inc Cloning genes from steptomyces avermitilis for avermectin biosynthesis
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
KR100221385B1 (ko) 1993-07-30 1999-10-01 디. 제이. 우드 스트렙토마이세스 아베르미틸리스로 부터의 측쇄 알파-케토산 데하이드로게나제 복합체를 암호화하는 유전자
RO115884B1 (ro) * 1993-10-05 2000-07-28 Pfizer Derivati de doramectin, procedeu de preparare, metoda de tratare
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
JP2002503473A (ja) * 1998-02-13 2002-02-05 ファイザー・プロダクツ・インク Ｂ２：ｂ１アベルメクチンの比に関するストレプトミセス・アベルミティリス遺伝子

Also Published As

Publication number Publication date
PL353770A1 (en) 2003-12-01
US20030124607A1 (en) 2003-07-03
AP2002002419A0 (en) 2002-03-31
PA8499201A1 (es) 2001-12-14
MXPA02001514A (es) 2002-07-02
US20030129636A1 (en) 2003-07-10
HRP20020131A2 (en) 2003-12-31
TNSN00170A1 (fr) 2005-11-10
EP1200605B1 (en) 2004-11-24
US6511841B2 (en) 2003-01-28
ATE283363T1 (de) 2004-12-15
GT200000138CA (es) 2002-02-02
AU5702100A (en) 2001-03-13
DE60016231T2 (de) 2005-12-08
US6248579B1 (en) 2001-06-19
NO20020665L (no) 2002-02-11
US20030134313A1 (en) 2003-07-17
IL147562A0 (en) 2002-08-14
US20030129635A1 (en) 2003-07-10
ES2231214T3 (es) 2005-05-16
HK1046536B (zh) 2005-05-13
CN1370239A (zh) 2002-09-18
PT1200605E (pt) 2005-04-29
YU8402A (sh) 2006-03-03
JP2005198658A (ja) 2005-07-28
CZ2002297A3 (cs) 2002-08-14
US20050196777A1 (en) 2005-09-08
KR20020022809A (ko) 2002-03-27
KR100486006B1 (ko) 2005-05-03
SK1382002A3 (en) 2002-11-06
CN1186447C (zh) 2005-01-26
BG106478A (bg) 2004-02-27
NO20020665D0 (no) 2002-02-11
AU779756B2 (en) 2005-02-10
US6833263B2 (en) 2004-12-21
US7259241B2 (en) 2007-08-21
AP2002002417A0 (en) 2002-03-31
DE60016231D1 (de) 2004-12-30
IS6249A (is) 2002-01-25
US6509159B2 (en) 2003-01-21
ZA200201071B (en) 2003-06-25
EA200200057A1 (ru) 2002-06-27
JP3688640B2 (ja) 2005-08-31
AR021450A1 (es) 2002-07-17
JP2003507018A (ja) 2003-02-25
BR0013093A (pt) 2002-08-13
GT200000138A (es) 2002-02-02
UY26287A1 (es) 2001-03-16
PE20010697A1 (es) 2001-07-05
WO2001012822A1 (en) 2001-02-22
EP1200605A1 (en) 2002-05-02
US7029887B2 (en) 2006-04-18
MA26811A1 (fr) 2004-12-20
HUP0202517A2 (hu) 2002-11-28
US20010024818A1 (en) 2001-09-27
HK1046536A1 (en) 2003-01-17
US20010016350A1 (en) 2001-08-23
EA004569B1 (ru) 2004-06-24
CA2381427A1 (en) 2001-02-22
CO5290296A1 (es) 2003-06-27

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