OA11737A - Methods and compositions useful in prophylaxis andtherapy of endotoxin related conditions. - Google Patents
Methods and compositions useful in prophylaxis andtherapy of endotoxin related conditions. Download PDFInfo
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- OA11737A OA11737A OA00100167A OA00100167A OA11737A OA 11737 A OA11737 A OA 11737A OA 00100167 A OA00100167 A OA 00100167A OA 00100167 A OA00100167 A OA 00100167A OA 11737 A OA11737 A OA 11737A
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- OA
- OAPI
- Prior art keywords
- pharmaceutical composition
- phospholipid
- composition according
- neutral lipid
- bile acid
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- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 238000011321 prophylaxis Methods 0.000 title claims abstract description 6
- 239000002158 endotoxin Substances 0.000 title abstract description 41
- 238000000034 method Methods 0.000 title description 6
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 55
- 239000003613 bile acid Substances 0.000 claims abstract description 43
- 150000002632 lipids Chemical class 0.000 claims abstract description 43
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims abstract description 39
- 230000007935 neutral effect Effects 0.000 claims abstract description 37
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 14
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- 238000011282 treatment Methods 0.000 claims abstract description 7
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 38
- 208000037487 Endotoxemia Diseases 0.000 claims description 12
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical group [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 claims description 10
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- 238000001990 intravenous administration Methods 0.000 claims description 7
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- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims description 4
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- WDFRNBJHDMUMBL-OICFXQLMSA-M sodium;(4r)-4-[(3r,5s,7r,8r,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)CC1 WDFRNBJHDMUMBL-OICFXQLMSA-M 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- RPKLZQLYODPWTM-KBMWBBLPSA-N cholanoic acid Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC(O)=O)C)[C@@]1(C)CC2 RPKLZQLYODPWTM-KBMWBBLPSA-N 0.000 claims 4
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/288,568 US5506218A (en) | 1992-08-12 | 1994-08-10 | Methods useful in endotoxin based therapy |
| US08/487,459 US5674855A (en) | 1992-08-12 | 1995-06-07 | Methods and compositions useful in prophylaxis and therapy of endotoxin related conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11737A true OA11737A (en) | 2005-05-12 |
Family
ID=26965092
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA00100167A OA11737A (en) | 1994-08-10 | 1995-08-10 | Methods and compositions useful in prophylaxis andtherapy of endotoxin related conditions. |
| OA60963A OA10598A (en) | 1994-08-10 | 1997-02-07 | Methods and compositions useful in prophylaxis an d therapy of endotoxin related conditions |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA60963A OA10598A (en) | 1994-08-10 | 1997-02-07 | Methods and compositions useful in prophylaxis an d therapy of endotoxin related conditions |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5674855A (de) |
| EP (1) | EP0767666B1 (de) |
| JP (1) | JP3818660B2 (de) |
| CN (1) | CN1137688C (de) |
| AP (1) | AP782A (de) |
| AT (1) | ATE255415T1 (de) |
| AU (1) | AU703861C (de) |
| BG (1) | BG61967B1 (de) |
| BR (1) | BR9508584A (de) |
| CA (1) | CA2196906C (de) |
| CY (1) | CY2514B1 (de) |
| CZ (1) | CZ287614B6 (de) |
| DE (1) | DE69532239T2 (de) |
| DK (1) | DK0767666T3 (de) |
| ES (1) | ES2211915T3 (de) |
| FI (1) | FI118035B (de) |
| HU (1) | HUT77605A (de) |
| NO (1) | NO313786B1 (de) |
| NZ (1) | NZ292315A (de) |
| OA (2) | OA11737A (de) |
| PL (1) | PL182043B1 (de) |
| PT (1) | PT767666E (de) |
| RO (1) | RO115782B1 (de) |
| RU (1) | RU2174839C2 (de) |
| SK (1) | SK282493B6 (de) |
| WO (1) | WO1996004916A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046166A (en) | 1997-09-29 | 2000-04-04 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6004925A (en) | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6518412B1 (en) | 1997-09-29 | 2003-02-11 | Jean-Louis Dasseux | Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6037323A (en) | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| ATE365043T1 (de) * | 1999-03-09 | 2007-07-15 | Anker Stefan | Endotoxinhemmern zur behandlung von kachexie |
| US20030032674A1 (en) * | 2001-08-13 | 2003-02-13 | Hwang Daniel H. | Use of unsaturated fatty acids to treat severe inflammatory diseases |
| AU2003239489A1 (en) | 2002-05-17 | 2003-12-02 | Esperion Therapeutics, Inc. | Method of treating dyslipidemic disorders |
| JP2006516614A (ja) * | 2003-02-05 | 2006-07-06 | エヌ．ブイ．・ヌートリシア | 敗血症の予防および／または治療のための経腸組成物 |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US7754230B2 (en) * | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| ES2660172T3 (es) * | 2004-05-19 | 2018-03-21 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Composición inyectable que comprende desoxicolato de sodio |
| EP1933856A4 (de) * | 2005-08-29 | 2008-11-19 | Sepsicure L L C | Verfahren zur behandlung oder vorbeugung von durch gram-positiven bakterien verursachten umständen |
| GB0522942D0 (en) | 2005-11-10 | 2005-12-21 | Leigh Steven | Dissolution composition |
| CA2653840A1 (en) | 2006-06-01 | 2007-12-06 | Institut De Cardiologie De Montreal | Use of a peptide/phospholipid complex acting as a reverse lipid transport agonist for treatment of valvular stenosis |
| KR100785656B1 (ko) * | 2007-05-14 | 2007-12-17 | 재단법인서울대학교산학협력재단 | 소염제로 사용되는 소디움글리코콜레이트 또는 그 유도체 |
| RU2351351C1 (ru) * | 2007-08-08 | 2009-04-10 | Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) | Средство, повышающее неспецифическую сопротивляемость организма к бактериальным эндотоксинам |
| LT2939683T (lt) | 2009-02-16 | 2017-03-27 | Cerenis Therapeutics Holding Sa | Apolipoproteino a-i mimetikai |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| US9023833B2 (en) * | 2012-12-18 | 2015-05-05 | Sepsicure, LLC | Method for treating sepsis in patients with albumin, cholesterol and HDL levels above minimum thresholds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115313A (en) * | 1974-10-08 | 1978-09-19 | Irving Lyon | Bile acid emulsions |
| DE2556592C2 (de) * | 1975-12-16 | 1986-10-09 | A. Nattermann & Cie GmbH, 5000 Köln | Arzneimittelzubereitungen auf Basis öliger Lösungen von Phospholipiden |
| US4314997A (en) * | 1980-10-06 | 1982-02-09 | Edward Shanbrom | Purification of plasma protein products |
| IL63734A (en) * | 1981-09-04 | 1985-07-31 | Yeda Res & Dev | Lipid fraction,its preparation and pharmaceutical compositions containing same |
| CA1237671A (en) * | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
| JPS6193111A (ja) * | 1984-05-28 | 1986-05-12 | Funayama Seizo | 発熱性物質除去方法 |
| US5032585A (en) * | 1987-02-17 | 1991-07-16 | Board Of Regents, The University Of Texas System | Methods and compositions employing unique mixtures of polar and neutral lipids for surfactant replacement therapy |
| AU614465B2 (en) * | 1989-04-05 | 1991-08-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| DE4017979A1 (de) * | 1990-06-05 | 1991-12-12 | Meyer Lucas Gmbh & Co | Lipid- bzw. phospholipid-zusammensetzungen sowie diese enthaltendes mittel zur behandlung von erkrankungen sowie auf die zellmembrane zurueckzufuehrende stoerungen |
| BR9201168A (pt) * | 1992-04-02 | 1994-04-12 | Zerbini E J Fundacao | Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas |
-
1995
- 1995-06-07 US US08/487,459 patent/US5674855A/en not_active Expired - Lifetime
- 1995-08-10 NZ NZ292315A patent/NZ292315A/en not_active IP Right Cessation
- 1995-08-10 BR BR9508584A patent/BR9508584A/pt not_active IP Right Cessation
- 1995-08-10 DE DE69532239T patent/DE69532239T2/de not_active Expired - Lifetime
- 1995-08-10 AP APAP/P/1997/000921A patent/AP782A/en active
- 1995-08-10 CA CA002196906A patent/CA2196906C/en not_active Expired - Lifetime
- 1995-08-10 AU AU34052/95A patent/AU703861C/en not_active Expired
- 1995-08-10 EP EP95930812A patent/EP0767666B1/de not_active Expired - Lifetime
- 1995-08-10 HU HU9700406A patent/HUT77605A/hu unknown
- 1995-08-10 CN CNB951951734A patent/CN1137688C/zh not_active Expired - Lifetime
- 1995-08-10 SK SK176-97A patent/SK282493B6/sk not_active IP Right Cessation
- 1995-08-10 ES ES95930812T patent/ES2211915T3/es not_active Expired - Lifetime
- 1995-08-10 RO RO97-00266A patent/RO115782B1/ro unknown
- 1995-08-10 JP JP50750296A patent/JP3818660B2/ja not_active Expired - Fee Related
- 1995-08-10 AT AT95930812T patent/ATE255415T1/de active
- 1995-08-10 PT PT95930812T patent/PT767666E/pt unknown
- 1995-08-10 DK DK95930812T patent/DK0767666T3/da active
- 1995-08-10 OA OA00100167A patent/OA11737A/en unknown
- 1995-08-10 PL PL95318593A patent/PL182043B1/pl unknown
- 1995-08-10 CZ CZ1997371A patent/CZ287614B6/cs not_active IP Right Cessation
- 1995-08-10 WO PCT/US1995/010189 patent/WO1996004916A1/en not_active Ceased
- 1995-08-10 RU RU97104061/14A patent/RU2174839C2/ru active
-
1997
- 1997-02-07 FI FI970534A patent/FI118035B/fi not_active IP Right Cessation
- 1997-02-07 OA OA60963A patent/OA10598A/en unknown
- 1997-02-07 NO NO19970582A patent/NO313786B1/no not_active IP Right Cessation
- 1997-03-05 BG BG101288A patent/BG61967B1/bg unknown
-
2005
- 2005-06-03 CY CY0500036A patent/CY2514B1/xx unknown
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