OA11438A - Novel macrolides. - Google Patents

Novel macrolides. Download PDF

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Publication number
OA11438A
OA11438A OA1200000192A OA1200000192A OA11438A OA 11438 A OA11438 A OA 11438A OA 1200000192 A OA1200000192 A OA 1200000192A OA 1200000192 A OA1200000192 A OA 1200000192A OA 11438 A OA11438 A OA 11438A
Authority
OA
OAPI
Prior art keywords
alkyl
groups
optionally
substituted
halo
Prior art date
Application number
OA1200000192A
Other languages
English (en)
Inventor
John Philip Dirlam
Hamish Alastair Irvin Mcarthur
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11438A publication Critical patent/OA11438A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
OA1200000192A 1998-01-02 2000-06-30 Novel macrolides. OA11438A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7034398P 1998-01-02 1998-01-02

Publications (1)

Publication Number Publication Date
OA11438A true OA11438A (en) 2004-04-30

Family

ID=22094723

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000192A OA11438A (en) 1998-01-02 2000-06-30 Novel macrolides.

Country Status (34)

Country Link
US (2) US6472371B1 (fr)
EP (1) EP1044207A1 (fr)
JP (1) JP2002500230A (fr)
KR (1) KR100352809B1 (fr)
CN (1) CN1284081A (fr)
AP (1) AP9801420A0 (fr)
AR (4) AR014948A1 (fr)
AU (1) AU756409B2 (fr)
BG (1) BG104644A (fr)
BR (1) BR9814601A (fr)
CA (1) CA2316919C (fr)
CO (1) CO4970821A1 (fr)
CZ (1) CZ20002458A3 (fr)
DZ (1) DZ2698A1 (fr)
EA (1) EA200000594A1 (fr)
GT (1) GT199800206A (fr)
HR (1) HRP20000442A2 (fr)
HU (1) HUP0100420A3 (fr)
IL (1) IL137024A0 (fr)
IS (1) IS5528A (fr)
MA (1) MA24729A1 (fr)
NO (1) NO20003347L (fr)
NZ (1) NZ504986A (fr)
OA (1) OA11438A (fr)
PA (1) PA8465301A1 (fr)
PE (1) PE20000049A1 (fr)
PL (1) PL341642A1 (fr)
SK (1) SK9782000A3 (fr)
TN (1) TNSN98238A1 (fr)
TW (1) TW520374B (fr)
UY (2) UY25330A1 (fr)
WO (1) WO1999035156A1 (fr)
YU (1) YU41500A (fr)
ZA (1) ZA9811939B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP9801420A0 (en) 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (fr) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11-carbamates des macrolides antibactériens
EP1754700A3 (fr) 1999-01-27 2007-05-09 Kosan Biosciences, Inc. synthese de polycetides
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
AP2001002302A0 (en) 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
AU2003211668A1 (en) * 2002-02-26 2003-09-09 Meiji Seika Kaisha, Ltd. Novel 15-membered cyclic azalide, novel 16-membered cyclic diazalide derivative, and process for producing these
PE20060693A1 (es) 2004-09-23 2006-09-01 Schering Plough Ltd Nuevos derivados de trifluorometansulfonanilida oxamida eter
DE602005017419D1 (de) * 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
EP1836211B1 (fr) 2004-12-21 2010-03-03 Pfizer Products Inc. Macrolides
PE20070108A1 (es) * 2005-06-09 2007-02-09 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n-[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CA2672795A1 (fr) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Promedicaments solubles dans l'eau de chloramphenicol, thiamphenicol et analogues de ceux-ci
CA2672586A1 (fr) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Promedicaments de florfenicol solubles dans l'eau et analogues
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN101743000A (zh) 2007-06-27 2010-06-16 杜邦公司 动物虫害控制方法
WO2009064953A1 (fr) * 2007-11-15 2009-05-22 Enanta Pharmaceuticals, Inc. Utilisation de dérivés de tylosine ou de macrolides pontés pour le traitement d'affections intestinales inflammatoires non spécifiques
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
WO2010014566A2 (fr) * 2008-07-30 2010-02-04 Intervet International B.V. Procédé de préparation de composés aminodiol d'oxazoline protégés utiles comme produits intermédiaires dans la production de florfénicol
KR20120050467A (ko) 2009-08-05 2012-05-18 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
AU2011258621B2 (en) 2010-05-27 2014-08-14 Corteva Agriscience Llc Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4, 5 - dihydro - 5 - (trifluoromethyl) -3 - isoxazolyl] -N- [2-0x0-2- [ ( 2, 2, 2 - trifluoroethyl) amino] ethyl] -1- naphthalenecarboxamide
WO2012087630A1 (fr) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Composés de pyridine et de pyrimidine utilisés pour lutter contre des nuisibles invertébrés
AU2012211760A1 (en) * 2011-01-31 2013-08-15 Meiji Seika Pharma Co., Ltd. Novel macrolide derivative
AU2012273133A1 (en) 2011-06-20 2013-11-07 E. I. Du Pont De Nemours And Company Heterocyclic compounds for treating helminth infections
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
KR20140094026A (ko) 2011-11-28 2014-07-29 이 아이 듀폰 디 네모아 앤드 캄파니 N-(4-퀴놀리닐메틸) 설폰아미드 유도체 및 구충제로서의 이의 용도
WO2013158422A1 (fr) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Composés hétérocycliques pour la lutte contre des animaux nuisibles invertébrés
WO2014099837A1 (fr) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anti-helminthique
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652537A (en) * 1969-11-21 1972-03-28 Lilly Co Eli Epierythromycylamine and epierythromycyl b amine
US3923784A (en) * 1973-09-10 1975-12-02 Hoffmann La Roche Erythromycin a derivatives
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4585759A (en) * 1985-01-22 1986-04-29 Pfizer Inc. Antibacterial derivatives of a neutral macrolide
EP0283055B1 (fr) * 1987-09-03 1990-08-29 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. Dérivés de 10-dihydro-10-déoxo-11-azaérythronolide-A, procédés et intermédiaires pour leur préparation et leur utilisation dans et pour la préparation de médicaments
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
WO1993013663A1 (fr) 1992-01-17 1993-07-22 Abbott Laboratories Procede permettant d'effectuer la biosynthese de polycetides specifiques
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2065218A1 (fr) 1991-04-11 1992-10-12 Robert R. Wilkening Procede d'obtention de 9-desoxo-8a-aza-8a-homoerythromycine a et de ses derives 8a-alkyle
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US6271255B1 (en) * 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
WO1998051696A1 (fr) * 1997-05-09 1998-11-19 Pfizer Products Inc. Derives d'erythromycine
US20020025937A1 (en) * 2000-03-20 2002-02-28 Yong-Jin Wu 9-oxime erythromycin derivatives
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
US6407074B1 (en) * 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
WO1999000124A1 (fr) 1997-06-26 1999-01-07 Merck & Co., Inc. 9a-azalides, compositions a base de ces composes et procedes therapeutiques
US6339063B1 (en) * 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
PA8461401A1 (es) * 1997-10-29 2000-05-24 Pfizer Prod Inc Derivados de eritromicina triciclicos
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AP9801420A0 (en) 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP0941998B1 (fr) * 1998-03-03 2004-09-01 Pfizer Products Inc. Antibiotiques macrolides de type 3,6-cétal
WO1999062920A1 (fr) * 1998-06-03 1999-12-09 Pfizer Products Inc. Derives 3-keto tricycliques de 6-o-methylerythromycine
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
ID28286A (id) * 1998-11-03 2001-05-10 Pfizer Prod Inc Antibiotik-antibiotik makrolida baru
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
AP2001002302A0 (en) 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
EP1101769A3 (fr) * 1999-11-18 2001-10-24 Pfizer Products Inc. Dérivés de l'érythromycine contenant de l'azote
WO2003014136A1 (fr) 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. Composes de 11a-azalide et methode de production de ces composes

Also Published As

Publication number Publication date
AR014948A1 (es) 2001-04-11
NO20003347D0 (no) 2000-06-27
JP2002500230A (ja) 2002-01-08
BR9814601A (pt) 2000-10-17
AU1444799A (en) 1999-07-26
NO20003347L (no) 2000-08-28
CZ20002458A3 (cs) 2001-10-17
CA2316919C (fr) 2004-10-26
PA8465301A1 (es) 2000-09-29
AR019787A2 (es) 2002-03-13
CN1284081A (zh) 2001-02-14
EP1044207A1 (fr) 2000-10-18
AU756409B2 (en) 2003-01-09
HUP0100420A2 (hu) 2001-07-30
TW520374B (en) 2003-02-11
US6472371B1 (en) 2002-10-29
AP9801420A0 (en) 1998-12-31
IL137024A0 (en) 2001-06-14
IS5528A (is) 2000-06-09
US7015203B2 (en) 2006-03-21
HRP20000442A2 (en) 2001-04-30
NZ504986A (en) 2003-03-28
YU41500A (sh) 2003-02-28
KR100352809B1 (ko) 2002-11-01
KR20010024818A (ko) 2001-03-26
UY25330A1 (es) 2000-12-29
US20040092459A1 (en) 2004-05-13
WO1999035156A1 (fr) 1999-07-15
EA200000594A1 (ru) 2001-04-23
GT199800206A (es) 2000-06-21
HUP0100420A3 (en) 2003-07-28
AR020551A2 (es) 2002-05-15
TNSN98238A1 (fr) 2005-03-15
UY25574A1 (es) 1999-09-27
PE20000049A1 (es) 2000-02-07
WO1999035156B1 (fr) 1999-10-21
SK9782000A3 (en) 2001-12-03
CA2316919A1 (fr) 1999-07-15
DZ2698A1 (fr) 2003-03-29
BG104644A (en) 2001-01-31
AR020851A2 (es) 2002-05-29
MA24729A1 (fr) 1999-07-01
PL341642A1 (en) 2001-04-23
ZA9811939B (en) 2000-06-30
CO4970821A1 (es) 2000-11-07

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