OA11390A - Anti-convulsant isoquinolyl-benzamide derivatives. - Google Patents

Anti-convulsant isoquinolyl-benzamide derivatives. Download PDF

Info

Publication number
OA11390A
OA11390A OA9900210A OA9900210A OA11390A OA 11390 A OA11390 A OA 11390A OA 9900210 A OA9900210 A OA 9900210A OA 9900210 A OA9900210 A OA 9900210A OA 11390 A OA11390 A OA 11390A
Authority
OA
OAPI
Prior art keywords
alkyl
4alkyl
hydrogen
disorders
phenyl
Prior art date
Application number
OA9900210A
Other languages
English (en)
Inventor
John David Harling
Barry Sydney Orlek
Mervyn Thompson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9705620.4A external-priority patent/GB9705620D0/en
Priority claimed from GBGB9726660.5A external-priority patent/GB9726660D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of OA11390A publication Critical patent/OA11390A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
OA9900210A 1997-03-18 1999-09-17 Anti-convulsant isoquinolyl-benzamide derivatives. OA11390A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9705620.4A GB9705620D0 (en) 1997-03-18 1997-03-18 Novel compounds
GBGB9726660.5A GB9726660D0 (en) 1997-12-17 1997-12-17 Novel compounds

Publications (1)

Publication Number Publication Date
OA11390A true OA11390A (en) 2004-04-14

Family

ID=26311216

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9900210A OA11390A (en) 1997-03-18 1999-09-17 Anti-convulsant isoquinolyl-benzamide derivatives.

Country Status (26)

Country Link
US (1) US6277861B1 (sk)
EP (1) EP0971897A1 (sk)
JP (1) JP2001516357A (sk)
KR (1) KR20000076343A (sk)
CN (1) CN1255917A (sk)
AP (1) AP9901635A0 (sk)
AR (1) AR012078A1 (sk)
AU (1) AU732162B2 (sk)
BG (1) BG103807A (sk)
BR (1) BR9809048A (sk)
CA (1) CA2283682A1 (sk)
CO (1) CO4950554A1 (sk)
DZ (1) DZ2446A1 (sk)
EA (1) EA199900836A1 (sk)
ID (1) ID22730A (sk)
IL (1) IL131958A0 (sk)
MA (1) MA24499A1 (sk)
NO (1) NO313753B1 (sk)
NZ (1) NZ337579A (sk)
OA (1) OA11390A (sk)
PE (1) PE62199A1 (sk)
PL (1) PL335675A1 (sk)
SK (1) SK126799A3 (sk)
TR (1) TR199902282T2 (sk)
TW (1) TW509679B (sk)
WO (1) WO1998041507A1 (sk)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016752A1 (en) * 1997-09-30 1999-04-08 Molecular Designs International, Inc. β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING
GB9817424D0 (en) 1998-08-11 1998-10-07 Smithkline Beecham Plc Novel compounds
GB9915589D0 (en) * 1999-07-02 1999-09-01 Smithkline Beecham Plc Novel compounds
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
CN109608325A (zh) * 2018-12-27 2019-04-12 先尼科化工（上海）有限公司 一种卤代苯甲酸衍生物的工业化合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022900A (en) * 1970-09-09 1977-05-10 Marion Laboratories, Inc. Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
WO1988003137A1 (en) * 1986-10-28 1988-05-05 Smith Kline & French Laboratories Limited Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof
US4883593A (en) * 1988-10-27 1989-11-28 Bend Research, Inc. Ultrathin-skinned asymmetric membranes by immiscible solvents treatment
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
PL330465A1 (en) * 1996-06-17 1999-05-24 Smithkline Beecham Plc Substituted benzamide derivatives and their application as anticonvulsants

Also Published As

Publication number Publication date
EA199900836A1 (ru) 2000-04-24
NZ337579A (en) 2001-04-27
BG103807A (bg) 2001-05-31
NO994504D0 (no) 1999-09-17
US6277861B1 (en) 2001-08-21
KR20000076343A (ko) 2000-12-26
DZ2446A1 (fr) 2003-01-11
AR012078A1 (es) 2000-09-27
CA2283682A1 (en) 1998-09-24
AU6412798A (en) 1998-10-12
ID22730A (id) 1999-12-09
CN1255917A (zh) 2000-06-07
AU732162B2 (en) 2001-04-12
AP9901635A0 (en) 1999-09-30
JP2001516357A (ja) 2001-09-25
CO4950554A1 (es) 2000-09-01
NO994504L (no) 1999-09-17
PL335675A1 (en) 2000-05-08
WO1998041507A1 (en) 1998-09-24
BR9809048A (pt) 2000-08-01
PE62199A1 (es) 1999-09-10
EP0971897A1 (en) 2000-01-19
IL131958A0 (en) 2001-03-19
MA24499A1 (fr) 1998-10-01
SK126799A3 (en) 2000-05-16
TW509679B (en) 2002-11-11
NO313753B1 (no) 2002-11-25
TR199902282T2 (en) 2000-07-21

Similar Documents

Publication Publication Date Title
WO2000007993A1 (en) Substituted isoquinoleines and their use as anticonvulsivants
AU737955B2 (en) Substituted isoquinoline derivatives and their use as anticonvulsants
AU729124B2 (en) Substituted benzamide derivatives and their use as anticonvulsants
US6248754B1 (en) Substituted isoquinoline derivatives and their use as anticonvulsants
OA11390A (en) Anti-convulsant isoquinolyl-benzamide derivatives.
US6274594B1 (en) Isoquinoline derivatives and their therapeutical use
CA2307030A1 (en) Substituted isoquinoline derivatives and their use as anticonvulsants
EP1200409B1 (en) Substituted isoquinoline derivatives and their use as anticonvulsants
EP1084122B1 (en) Tetrahydronaphthyridinyl-carboxamides having anti-convulsant activity
EP1005459A1 (en) Substituted isoquinolines as anticonvulsivants
EP1104404A1 (en) Substituted isoquinoline derivatives and their use as anticonvulsants
MXPA99008627A (en) Anti-convulsant isoquinolyl-benzamide derivatives
WO2000008022A1 (en) Urea derivatives
KR20000016715A (ko) 치환된 벤즈아미드 유도체 및 항경련제로서의그의 용도ㅔ